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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS Dean scoops prestigious award for analysis of book of Malachi
2017-05-15

Description: Prof Fanie Snyman book Tags: Prof Fanie Snyman book

Willem Louw, Chairperson of the UFS Council;
Dr Khotso Mokhele , Chancellor of the UFS,
Eleanor van der Westhuizen, from the Directorate
of Research Development; Prof Francis Petersen,
UFS Vice-Chancellor and Rector; Prof Fanie Snyman,
Dean of the Faculty of Theology; and
Prof Corli Witthuhn, Vice-Rector: Research.
Photo: Johan Roux

The most sought-after award at the UFS, the annual Book Prize for Distinguished Scholarship, was recently won by Prof Fanie Snyman, Dean of the Faculty of Theology and Religion. His book, Malachi, which is about the last book of the Old Testament, has received acknowledgement through this award. He is the third academic to be awarded this prize. The book was published in English by Peeters Publishers in Belgium as part of the ”Historical Commentary on the Old Testament” series with a view to an international audience, and can be used by theology scholars and academics.

Labour of love over many years
Prof Snyman has a long history with the Bible book of Malachi. Since his student years, this book in the so-called ‘Minor Prophets’ of the Old Testament had a special charm for him. In fact, Prof Snyman has produced several publications on this concise book of 55 verses over the years. Furthermore, his doctoral thesis, as well as several papers delivered at congresses, also had this book as the theme. It took Prof Snyman about a decade to write the book.

What lies ahead for him in the future? “I am closing the book Malachi for the time being,” says Prof Snyman. “However, my research on the ‘Minor Prophets’ will continue. As a result of Malachi, InterVarsity Press in Cambridge contacted me for the writing of a book in another international commentary series, this time on the books Nahum, Habakkuk, and Zephaniah.” Prof Snyman will use his prize money of R75 000 towards this goal.

Book prize a surprise
“I can sincerely say that I did not expect the award at all. I did not know which other excellent research was submitted and thought that research from another discipline might do better. Therefore, I was completely surprised when my book was announced as the winner, and it left me speechless at the moment!” says a modest Prof Snyman.

He adds: “I am sincerely grateful for this award, but I must also thank the university. I would like to express my appreciation for the academic milieu, financial support, as well as overseas travel opportunities that have enabled me to complete the book and achieve this award.”
 
Book review by international expert
Prof Rainer Kessler, a world-renowned expert on the Bible book of Malachi, said in a review of Malachi: “The commentary on Malachi in the renowned Historical Commentary on the Old Testament series is the fruit of decades of studies on the book. [It] is full of respect towards the text. [Prof] Snyman is very cautious in his judgements and decisions. He rather presents different possibilities than uttering one-sided positions. [Finally, he] treats others always in a very fair manner. He presents their opinions as objectively as possible, especially when he does not agree. This commentary is a new and very useful tool for the study on the often underestimated last book of the Old Testament prophets.”

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