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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Inaugural lecture: World on verge of agricultural revolution
2008-05-19

A changing economic climate and new technology will see to a number of interesting changes in the livestock industry in the next few years. This is according to Prof. Frikkie Neser of the Department of Animal and Wildlife and Grassland Sciences, who delivered his inaugural lecture at the UFS on the subject: “The quest for a superior animal”.

Prof. Neser focused on the future of animal breeding in the next few decades.

He said the world, but especially South Africa, stand on the verge of a revolution in the agriculture sector. The whole production scenario will probably change. The high fuel and food prices are the two biggest factors that will play a role.

“Increasing fuel prices opened the door for the production of bio-fuel. The fuel industry is in direct competition with humans and the livestock industry for the same resource that result in unbelievable high prices for maize, sunflower and soya. These prices can further increase with the worldwide shortage of food,” he said.

More profitable breeds could take the place of existing breeds because of the big increase in input costs, he said. “Selection for more effective, and not maximum production, will became more important.

“There are also indications of pressure on feed lots. If this industry downsizes, it could lead to a total turnaround in the beef industry. The feed lots prefer a later maturing animal that can put on a lot of weight before fat is laid down. If this industry declines, early maturing breeds and some of the synthetic breeds, as well as crossbreeding with early maturing breeds, will play a more prominent role in the meat industry.

“This will also lead to a decline in the total number of animals in order to prevent overgrazing. This can result in an increase in imports from neighbouring countries and especially Brazil, where production costs are much lower.

“One way to increase the profitability of meat production is to utilise niche markets. There is world-wide a shift to more natural products. The demand for grass-fed beef drastically increased. According to research it is healthier than meat from feed lots and usually free of hormones and antibiotics. If factors such as traceability are put in place, this could be a very profitable niche mark for the South African meat industry,” he said.

Prof. Neser also said: “In order for breeding societies to survive they need to increase the number of members and the animals that are being registered. This they do by replacing the word stud with recorded animals. Hereby they open the door for excellent commercial animals to become part of the seed-stock industry. Another benefit is that especially in the smaller breeds more information becomes available, resulting in more accurate breeding values.”

Prof. Frikkie Neser.

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