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13 December 2024 | Story Anthony Mthembu | Photo Charl Devenish
Lieutenant Colonel Dr Rifa Tshivhase
Lieutenant Colonel Dr Rifa Tshivhase, Head of the Department of Surgery at 3 Military Hospital in Bloemfontein, addressed graduates within the Faculty of Health Sciences at the University of the Free State on 10 December 2024.

Momentous and joyous – these are some of the words used to describe the December 2024 graduations at the University of the Free State (UFS). In celebration of the academic achievements of its students, the UFS hosted graduation ceremonies at the Callie Human Centre on its Bloemfontein Campus from 9 to 10 December 2024.

Prof Anthea Rhoda, acting Vice-Chancellor and Principal of the UFS, encouraged the graduates to always acknowledge and recognise the significance of this achievement as they transition from being UFS students to being UFS graduates.

Undergraduate and postgraduate achievements

At least 2000 undergraduate qualifications and postgraduate qualifications were conferred. As such, there were some standout academic achievements across the sessions. For instance, Itumeleng Pooe received his Advanced Diploma in Theology cum laude, making him the only graduate in the Faculty of Theology and Religion to receive his qualification with distinction during these graduations. In addition, Dr Bobuin Jr Valey Gemandze Oben – at just 28 years old – was the youngest PhD graduate from the Faculty of Law at the graduation ceremony, which took place on the morning of 9 December 2024.

Conferring Honorary Doctorates

Some highlights from these graduations were the recipients of honorary doctorates, as well as the keynote speakers. The Faculty of Economic and Management Sciences (EMS) at the UFS conferred an honorary degree on Prof Murray Leibbrandt, Research Chair in Poverty and Inequality Research in the Southern Africa Labour and Development Research Unit (SALDRU) at the University of Cape Town (UCT). In addition, the Faculty of The Humanities at the UFS conferred an honorary degree on HE Bineta Diop, Special Envoy of the Chairperson of the African Union Commission on Women, Peace, and Security.

On the final day of the graduations, graduates within the Faculty of Health Sciences at the UFS were addressed by Lieutenant Colonel Dr Rifa Tshivhase, Head of the Department of Surgery at 3 Military Hospital in Bloemfontein. In her address, Lieutenant Colonel Dr Tshivhase encouraged and challenged the graduates to actively seek out good in the world.

As the December 2024 graduations concluded, several of the graduates within the Faculty of Health Sciences indicated that the most memorable moments in the session were the cheers and applause they received as they walked across the stage.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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