Latest News Archive

Please select Category, Year, and then Month to display items

Dr Gladys Belle’s research dedicated to reducing impact of COVID drugs on water resources

11 February 2024 | Story Leonie Bolleurs | Photo SUPPLIED

Beyond the destruction caused by the Coronavirus during the COVID-19 pandemic, it continues to impact not only the lives of many people but also the environment.

Dr Gladys Belle, a postdoctoral researcher in the Centre for Environmental Management at the University of the Free State (UFS), is currently focusing her research on the risk assessment of pharmaceuticals of emerging concern in water resources, specifically concerning human health and aquatic ecosystems. She explains that her research investigates the occurrence, fate, and behaviour of four drugs used during COVID-19 and assesses the risk these drugs pose to human health and the aquatic ecosystem within the Orange-Senqu River Basin.

“I am passionate about water research and more passionate about human health. My interest in water and health-related research grew due to the health crisis caused by human exposure to contaminated water sources in South Africa,” she states.

Dr Belle adds that she wants to raise awareness and shape the behaviour of local communities in South Africa regarding safe disposal methods. Through programmes such as take-back initiatives, the research seeks to reduce the impact of pharmaceuticals on water resources. She states, “My research will also influence the implementation of various preventive measures, including policies regulating the disposal of drugs into the environment. This research may serve as the basis for better sanitation solutions within communities and improving wastewater treatment processes in the country.”

Focusing on women scientists such as Dr Belle, the UFS will be celebrating the United Nations International Day of Women and Girls in Science on 11 February, commemorating women in the field of science and encouraging girls to pursue careers in this field.

A passion for academia and science

From a young age, Dr Belle was deeply enthusiastic about academia, particularly in the field of science. She studied Environmental Sciences at a university in Cameroon, earning her BSc in 2003. Taking a ten-year break, she focused on being a mum and also worked as Biology teacher in Lesotho.

Despite staying away from the university for an extended period, Dr Belle never let go of her passion and vision to one day become a renowned researcher and academic. In 2012, she enrolled for her honours degree in Environmental Health, followed by her master's in 2013, which she passed with distinction. Immediately after, she enrolled for a PhD and successfully graduated in 2021.

She mentions that her PhD journey came with various challenges, balancing responsibilities as a part-time lecturer, a mother, and a wife while pursuing her studies. “Regardless of all those challenges, I never gave up. Instead, they kept me motivated to get going,” she says.

The same year that she obtained her PhD, Dr Belle joined the university as a postdoctoral researcher. “Being a researcher at the UFS has allowed me to advance my research career and provided a platform for me to meet and learn from the gurus in my field,” she comments. Dr Belle considers Prof Paul Oberholster, the Dean of the Faculty of Natural and Agricultural Sciences and her current supervisor, as a true mentor. He not only teaches her the skill of hard work, but he also encourages her to aim high in research. She also expresses great appreciation to the Directorate of Research Development for its support during her research journey, providing her with access to tools and resources to effectively pursue her work as researcher.

As postdoctoral researcher, Dr Belle expanded her research expertise by publishing in peer-reviewed journals and gaining experience in writing grants and managing projects. In 2023, she received two prestigious research grants. In the Water Research Commission grant, she is leading a team of six national and international experts in risk assessment of emerging contaminants in water resources.

Furthermore, Dr Belle received the Innovation Postdoctoral Fellowship award for 2023 from the National Research Foundation (NRF). She explains that the project focuses on investigating sources, pathways, occurrences, and potential risks of pharmaceuticals of emerging concern on potential receptors in water resources. “This study targets the different wastewater treatment plants (WWTP) in Mangaung, as these plants pose a potential risk of introducing pharmaceuticals into water systems,” she remarks.

Strengthening capacity development

Focusing on understanding the risks of new pollutants in water resources, Dr Belle is well on her way to becoming one of the leading researchers in water and health, a long-standing aspiration of hers. “I see myself working with top researchers in my field, both nationally and internationally, to be part of important international research projects, including working with the European Union and the United Nations,” she says.

In addition to making an impact on the international stage and collaborating with experts in her field, she also aims to transfer and share her skills to the postgraduate students working with her, thereby strengthening their development.

For girls and young women aspiring to embark on a journey in any field of science, her message is that it is possible. “Whatever career path you wish to pursue in sciences, put your mind to it and be passionate about what you do; ultimately, you will testify that ‘it is possible’,” Dr Belle concludes.

News Archive

#Women'sMonth: Save the children

2017-08-10

Dr Trudi O’Neill, Senior lecturer in the Department of
Microbial, Biochemical and Food Biotechnology.
Photo: Anja Aucamp

Dr Trudi O’Neill, Senior lecturer in the Department of Microbial, Biochemical and Food Biotechnology, is conducting research on rotavirus vaccines.

Dr O’Neill was inspired to conduct research on this issue through her fascination with the virus. “The biology of rotaviruses, especially the genome structure and the virus’ interaction with the host, is fascinating.”

“In fact, it is estimated that, globally, ALL children will be infected with rotavirus before the age of five, irrespective of their socio-economic standing. However, infants and young children in poor countries are more vulnerable due to inadequate healthcare. The WHO estimates that approximately 215 000 deaths occur each year. This roughly equates to eight Airbus A380 planes, the largest commercial carrier with a capacity of approximately 500 seats, filled with only children under the age of five, crashing each week of every year.”

Alternative to expensive medicines
“Currently, there are two vaccines that have been licensed for global use. However, these vaccines are expensive and poor countries, where the need is the greatest, are struggling to introduce them sustainably. It is therefore appealing to study rotaviruses, as it is scientifically challenging, but could at the same time have an impact on child health,” Dr O’Neill said.

The main focus of Dr O’Neill’s research is to develop a more affordable vaccine that can promote child vaccination in countries/areas that cannot afford the current vaccines.

All about a different approach
When asked about the most profound finding of her research, Dr O’Neill responded: “It is not so much a finding, but rather the approach. My rotavirus research group is making use of yeast as vehicle to produce a sub-unit vaccine. These microbes are attractive, as they are relatively easy to manipulate and cheap to cultivate. Downstream production costs can therefore be reduced. The system we use was developed by my colleagues, Profs Koos Albertyn and Martie Smit, and allows for the potential use of any yeast. This enables us to screen a vast number of yeasts in order to identify the best yeast producer.”

Vaccination recently acquired a bad name in the media for its adverse side effects. As researcher, Dr O’Neill has this to say: “Vaccines save lives. By vaccinating your child, you don’t just protect your own child from a potentially deadly infection, but also other children in your community that might be too young to be vaccinated or have pre-existing health problems that prevents vaccination.”

A future without rotavirus vaccination?
Dr O’Neill believes a future without rotavirus vaccination will be a major step backwards, as the impact of rotavirus vaccines has been profound. “Studies in Mexico and Malawi actually show a reduction in deaths. A colleague in Mozambique has commented on the empty hospital beds that amazed both clinicians and scientists only one year after the introduction of the vaccine in that country. Although many parents, mostly in developed countries, don’t have to fear dehydrating diarrhoea and potential hospitalisation of their babies due to rotavirus infection anymore, such an infection could still be a death sentence in countries that have not been able to introduce the vaccine in their national vaccination programmes,” she said.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept