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09 February 2024 | Story EDZANI NEPHALELA | Photo SUPPLIED
Jerry Dlamini
Dr Jerry Dlamini, lecturer and researcher specialising in agronomy within the Department of Soil, Crop, and Climate Sciences at the University of the Free State (UFS), is at the forefront of pioneering research in this field.

Greenhouse gas emissions represent a significant global concern, driving climate change on a massive scale. This concern is particularly pronounced in rainfed agriculture, where understanding and addressing these emissions are crucial for ensuring sustainable agricultural practices. 

In South Africa, rainfed agriculture is vital in food production, contributing substantially to the nation's agricultural output. However, this sector also stands as a notable contributor to greenhouse gas emissions, primarily through activities such as livestock farming, fertiliser use, and changes in land use.

Dr Jerry Dlamini, a distinguished lecturer and researcher specialising in agronomy within the Department of Soil, Crop, and Climate Sciences at the University of the Free State (UFS), is leading pioneering research in this field. His current project, @CROPGas on X, funded by the European Joint Programme (EPJ), with a budget of R22 million, focuses on investigating the impact of various conservation agriculture interventions on greenhouse gas emissions, primarily targeting nitrous oxide (N2O), methane (CH4), and carbon dioxide (CO2).

This two-year project, which commenced in December 2022 and concludes in December 2024, is a collaborative effort between European and African universities and institutions, including Rothamsted Research (UK), University College Dublin (Ireland), University of Nottingham (UK), University of Poznan (Poland), British Geological Surveys (BGS), University of Zambia (Zambia), University of Zimbabwe, and Lilongwe University of Agriculture and Natural Resources (Malawi). 

Dr Dlamini’s preliminary findings from the UFS Kenilworth Experimental Farm indicate that climate-smart agriculture interventions, such as legume rotation and no-till practices, have the potential to reduce the intensity of greenhouse gas emissions, particularly highly radiative gases like N2O.

“This is a significant finding,” Dr Dlamini noted, “as N2O has a global warming potential 100 times greater than CO2 over a 100-year horizon, meaning its impact on ozone depletion persists far longer despite being emitted in smaller quantities.”

Looking ahead, Dr Dlamini advocates for increased research efforts to quantify greenhouse gas emissions from South African croplands. He emphasises the importance of field-based measurements, akin to methodologies employed by other nations, to enhance the accuracy and effectiveness of South Africa's greenhouse gas inventories submitted annually to the United Nations Framework Convention on Climate Change (UNFCCC) and to devise effective mitigation strategies. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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