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21 February 2024 | Story Leonie Bolleurs | Photo SUPPLIED
Bridging Knowledge Cultures
A group of academics from the University of the Free State (UFS) and the North-West University (NWU) contributed to a chapter in the book Bridging Knowledge Cultures in Rural Health Education, which was recently launched during an online event.

The Directorate of Community Engagement at the University of the Free State (UFS) celebrated the publication of a chapter in the book, Bridging Knowledge Cultures. This transformative book was edited by Walter Lepore, Budd Hall, and Rajesh Tandon, Unesco co-chairs of the Unesco Chair in Community Based Research and Social Responsibility in Higher Education.

Chapter 10 of the book – ‘Bridging Knowledge Cultures in Rural Health Education’ – was contributed by a group of academics from the UFS and the North-West University (NWU). The UFS contributors included Dr Karen Venter, Head of Service-Learning in the Directorate of Community Engagement; Alfi Moolman, former coordinator in the same department; and Dr René Walter Botha, Coordinator for Community Based Education and Rural Health in the Faculty of Health Sciences. From the NWU, the contributors included Prof Lesley Wood, Extraordinary Professor in Community-Based Educational Research; Beatrix (Bibi) Bouwman, Director for Sustainability and Community Impact; and Prof Hendri Coetzee, Extraordinary Associate Professor in the North-West University’s COMPRES research unit.

Identify knowledge differences/gaps

According to Dr Venter, the study conducted in the Xhariep District was considered a unique context for an in-depth exploration of participants’ subjective experiences to identify knowledge differences/gaps, and recommendations to bridge them. She states, “The aim of the initiative was to improve health outcomes by establishing lifestyle groups to enable the sharing of health information among participants and thereby encourage sustainable, accountable lifestyle practices.” 

Three questions derived from the case study were discussed during the launch: Who has the right to create knowledge? Who decides if knowledge is valid? And who will have access to the knowledge?

Other case studies included in the book also explored the dynamics of equitable research partnerships, providing practical recommendations to overcome obstacles and forge effective collaboration between academia and diverse communities.

Embrace the richness of diverse perspectives

Dr Venter believes that the launch event inspired the next generation of researchers and professionals to embrace the richness of diverse perspectives and knowledge cultures.

To access the rest of the case studies, including those from Indonesia, Malaysia, and India, you can download the book here. Access the discussion on YouTube here.

Parallel to the book, a guide was launched: Bridging Knowledge Cultures: A Guide for Community Practitioners and Community Organisations. You can access a copy here.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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