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21 February 2024 | Story Leonie Bolleurs | Photo SUPPLIED
Bridging Knowledge Cultures
A group of academics from the University of the Free State (UFS) and the North-West University (NWU) contributed to a chapter in the book Bridging Knowledge Cultures in Rural Health Education, which was recently launched during an online event.

The Directorate of Community Engagement at the University of the Free State (UFS) celebrated the publication of a chapter in the book, Bridging Knowledge Cultures. This transformative book was edited by Walter Lepore, Budd Hall, and Rajesh Tandon, Unesco co-chairs of the Unesco Chair in Community Based Research and Social Responsibility in Higher Education.

Chapter 10 of the book – ‘Bridging Knowledge Cultures in Rural Health Education’ – was contributed by a group of academics from the UFS and the North-West University (NWU). The UFS contributors included Dr Karen Venter, Head of Service-Learning in the Directorate of Community Engagement; Alfi Moolman, former coordinator in the same department; and Dr René Walter Botha, Coordinator for Community Based Education and Rural Health in the Faculty of Health Sciences. From the NWU, the contributors included Prof Lesley Wood, Extraordinary Professor in Community-Based Educational Research; Beatrix (Bibi) Bouwman, Director for Sustainability and Community Impact; and Prof Hendri Coetzee, Extraordinary Associate Professor in the North-West University’s COMPRES research unit.

Identify knowledge differences/gaps

According to Dr Venter, the study conducted in the Xhariep District was considered a unique context for an in-depth exploration of participants’ subjective experiences to identify knowledge differences/gaps, and recommendations to bridge them. She states, “The aim of the initiative was to improve health outcomes by establishing lifestyle groups to enable the sharing of health information among participants and thereby encourage sustainable, accountable lifestyle practices.” 

Three questions derived from the case study were discussed during the launch: Who has the right to create knowledge? Who decides if knowledge is valid? And who will have access to the knowledge?

Other case studies included in the book also explored the dynamics of equitable research partnerships, providing practical recommendations to overcome obstacles and forge effective collaboration between academia and diverse communities.

Embrace the richness of diverse perspectives

Dr Venter believes that the launch event inspired the next generation of researchers and professionals to embrace the richness of diverse perspectives and knowledge cultures.

To access the rest of the case studies, including those from Indonesia, Malaysia, and India, you can download the book here. Access the discussion on YouTube here.

Parallel to the book, a guide was launched: Bridging Knowledge Cultures: A Guide for Community Practitioners and Community Organisations. You can access a copy here.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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