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20 February 2024 | Story Lacea Loader | Photo SUPPLIED
Prof Bob Frater
The late Prof Robert Frater, after whom the Robert WM Frater Cardiovascular Research Centre at the UFS was named.

The Robert WM Frater Cardiovascular Research Centre (the Frater Centre) at the University of the Free State (UFS) received the sad news of the passing of Prof Robert (Bob) Frater at the age of 95 on 29 January 2024 in New York. 

“Prof Frater was and will continue to be regarded as an international icon in heart surgery, especially in mitral valve repair where he described the use of artificial chordae, which is still the international standard today.  Since 2006, he has been intimately involved in the establishment of the research programme in the Department of Cardiothoracic Surgery at the UFS, which culminated in the establishment of the Frater Centre in 2015. This would not have been possible without the combined efforts of the UFS and the generous financial support by Glycar – a Pretoria-based company established by Prof Frater,” says Prof Francis Smit, Director of the Robert WM Frater Cardiovascular Research Centre and Head of the Department of Cardiothoracic Surgery at the UFS.

Prof Frater was born in Cape Town and attended Bishops Diocesan College from 1937 to 1946. He excelled at school, both academically and as a sportsman. He was a prefect, captained the tennis team, and played first team rugby. He studied medicine at the University of Cape Town (UCT), achieving a first class in Surgery. He qualified as a cardiothoracic surgeon at the Mayo Clinic and after a stint back in Cape Town, spent the rest of his illustrious career at the Einstein and Montefiore university hospitals in New York. Despite this distance, Prof Frater always maintained and cherished his South African roots, palpably demonstrated by his notable collection of Africana books and art.

“He was an inspiring mentor and educator, and constructively influenced generations of cardiothoracic surgeons trained at the UFS and internationally. His enthusiasm for scientific research and deep understanding of heart valves and tissue engineering have largely determined the research focus of the Frater Centre to this day.  He received an honorary doctorate in Medicine from the UFS in 2011 in recognition of his immense contributions to cardiothoracic surgery during his lifetime. Apart from his international recognition and awards, the other outstanding award he received and cherished in South Africa, was the Robert Gray Medal from his old school, Bishops Diocesan College,” says Prof Smit.

At the UFS, he was Prof Smit’s promotor for his PhD on human heart valve transplants (homografts) and inspired an additional five PhD studies (four of which addressed tissue engineering, and one in re-designing a poppet mechanical heart valve, which was named the Frater valve).  Studies on heart valve mechanics and hydrodynamics conducted at the Frater Centre in support of these valve developments resulted in three cum laude Master of Engineering degrees awarded by Stellenbosch University.  Over time, the Robert WM Frater Cardiovascular Research Centre’s research output steadily increased in scope and quality, mainly due to the values of curiosity, excellence, integrated interdisciplinary collaborative teams, integrity, and mutual respect instilled by Prof Bob Frater.

“Prof Frater was always received ostentatiously in Bloemfontein. The registrars crowded around him, our research team was inspired, wisdom was gained from his vast experience in surgery and research, and no-one was left untouched by the deep humanity of this remarkable man. He was truly an exceptional individual, and a memorable South African.”

We wish to express our sincerest condolences and deepest sympathy to his wife Eileen, sons Hugh, Dirk, and the rest of the family,” says Prof Smit.

News Archive

UFS scientists involved in groundbreaking research to protect rhino horns
2010-07-27

Pictured from the left are: Prof. Paul Grobler (UFS), Prof. Antoinette Kotze (NZG) and Ms. Karen Ehlers (UFS).
Photo: Supplied

Scientists at the University of the Free State (UFS) are involved in a research study that will help to trace the source of any southern white rhino product to a specific geographic location.

This is an initiative of the National Zoological Gardens of South Africa (NZG).

Prof. Paul Grobler, who is heading the project in the Department of Genetics at the UFS, said that the research might even allow the identification of the individual animal from which a product was derived. This would allow law enforcement agencies not only to determine with certainty whether rhino horn, traded illegally on the international black market, had its origin in South Africa, but also from which region of South Africa the product came.

This additional knowledge is expected to have a major impact on the illicit trade in rhino horn and provide a potent legal club to get at rhino horn smugglers and traders.

The full research team consists of Prof. Grobler; Christiaan Labuschagne, a Ph.D. student at the UFS; Prof. Antoinette Kotze from the NZG, who is also an affiliated professor at the UFS; and Dr Desire Dalton, also from the NZG.

The team’s research involves the identification of small differences in the genetic code among white rhino populations in different regions of South Africa. The genetic code of every species is unique, and is composed of a sequence of the four nucleotide bases G, A, T and C that are inherited from one generation to the next. When one nucleotide base is changed or mutated in an individual, this mutated base is also inherited by the individual's progeny.

If, after many generations, this changed base is present in at least 1% of the individuals of a group, it is described as a single nucleotide polymorphism (SNP), pronounced "snip". Breeding populations that are geographically and reproductively isolated often contain different patterns of such SNPs, which act as a unique genetic signature for each population.

The team is assembling a detailed list of all SNPs found in white rhinos from different regions in South Africa. The work is done in collaboration with the Pretoria-based company, Inqaba Biotech, who is performing the nucleotide sequencing that is required for the identification of the SNPs.

Financial support for the project is provided by the Advanced Biomolecular Research cluster at the UFS.

The southern white rhino was once thought to be extinct, but in a conservation success story the species was boosted from an initial population of about 100 individuals located in KwaZulu-Natal at the end of the 19th century, to the present population of about 15 000 individuals. The southern white rhino is still, however, listed as “near threatened” by the World Wildlife Fund (WWF).

Media Release:
Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za 
27 July 2010



 

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