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Infant body composition research revolutionised with new PEA POD® technology

25 January 2024 | Story Leonie Bolleurs | Photo Sonia Small

Prof Corinna Walsh says the PEA POD Infant Body Composition System works by directly measuring an infant’s body weight and volume, and then uses these measurements to calculate the body fat percentage, fat mass, and fat-free mass.

Nutritional and growth patterns during early life have been associated with health, development, and well-being throughout the life cycle. It is also associated with risks for developing obesity and non-communicable diseases, such as cardiometabolic diseases, later in life. These are the findings of Prof Corinna Walsh, Professor in the Department of Nutrition and Dietetics.

Maternal and child health

”In line with national priorities, a strong research focus area of the Faculty of Health Sciences and the School of Health and Rehabilitation Sciences is maternal and child health,” she says. She goes on to mention that the Department of Nutrition and Dietetics has established a reputable research programme. This programme focuses primarily on the nutritional status of pregnant women and how the early environment to which they are exposed during and after pregnancy affects short- and long-term health outcomes of the offspring.

“In our previous work, the assessment of birth outcomes of infants was, however, limited by the lack of equipment to analyse body composition. The research that we can conduct with the PEA POD® provides us with immense additional potential,” remarks Prof Walsh.

She explains, “The PEA POD Infant Body Composition System is an infant-sized air displacement plethysmography system. It works by directly measuring an infant’s body weight and volume, and then uses these measurements to calculate the body fat percentage, fat mass, and fat-free mass.

According to her, the assessment of body volume takes two minutes. “The PEA POD technique also does not require collection of any fluids and does not expose the infant to radiation. It can be performed as often as required without any risks and be used up to a maximum of 8-10 kg body weight, from birth to about eight months,” she says.

Advanced technology

In the context of research on infant body weight and composition, there is a need for accurate measurement techniques that can differentiate between fat mass and fat-free mass. Prof Walsh is of the opinion that traditional measures such as body mass index (BMI) and weight for length have limitations in this regard, as they do not provide a clear distinction between these components. Furthermore, BMI may not be reliable for assessing adiposity or obesity in paediatric populations, and it can vary significantly with age and gender.

Addressing these challenges, the PEA POD equipment offers advanced technology that allows for highly accurate quantification of infant body composition. This technological capability opens up opportunities to study the effects of early-life nutrition on growth and the developmental mechanisms that may lead to later comorbidities. So, when it comes to researching infant body weight and composition, the PEA POD equipment plays a crucial role in providing precise data and insights.

News Archive

Nanotechnology breakthrough at UFS

2010-08-19

Ph.D students, Chantel Swart and Ntsoaki Leeuw

Scientists at the University of the Free State (UFS) made an important breakthrough in the use of nanotechnology in medical and biological research. The UFS team’s research has been accepted for publication by the internationally accredited Canadian Journal of Microbiology.

The UFS study dissected yeast cells exposed to over-used cooking oil by peeling microscopically thin layers off the yeast cells through the use of nanotechnology.

The yeast cells were enlarged thousands of times to study what was going on inside the cells, whilst at the same time establishing the chemical elements the cells are composed of. This was done by making microscopically small surgical incisions into the cell walls.

This groundbreaking research opens up a host of new uses for nanotechnology, as it was the first study ever in which biological cells were surgically manipulated and at the same time elemental analysis performed through nanotechnology. According to Prof. Lodewyk Kock, head of the Division Lipid Biotechnology at the UFS, the study has far reaching implications for biological and medical research.

The research was the result of collaboration between the Department of Microbial, Biochemical and Food Biotechnology, the Department of Physics (under the leadership of Prof. Hendrik Swart) and the Centre for Microscopy (under the leadership of Prof.Pieter van Wyk).

Two Ph.D. students, Chantel Swart and Ntsoaki Leeuw, overseen by professors Kock and Van Wyk, managed to successfully prepare yeast that was exposed to over-used cooking oil (used for deep frying of food) for this first ever method of nanotechnological research.

According to Prof. Kock, a single yeast cell is approximately 5 micrometres long. “A micrometre is one millionth of a metre – in laymen’s terms, even less than the diameter of a single hair – and completely invisible to the human eye.”

Through the use of nanotechnology, the chemical composition of the surface of the yeast cells could be established by making a surgical incision into the surface. The cells could be peeled off in layers of approximately three (3) nanometres at a time to establish the effect of the oil on the yeast cell’s composition. A nanometre is one thousandth of a micrometre.

Each cell was enlarged by between 40 000 and 50 000 times. This was done by using the Department of Physics’ PHI700 Scanning Auger Nanoprobe linked to a Scanning Electron Microscope and Argon-etching. Under the guidance of Prof. Swart, Mss. Swart en Leeuw could dissect the surfaces of yeast cells exposed to over-used cooking oil.

The study noted wart like outgrowths - some only a few nanometres in diameter – on the cell surfaces. Research concluded that these outgrowths were caused by the oil. The exposure to the oil also drastically hampered the growth of the yeast cells. (See figure 1)

Researchers worldwide have warned about the over-usage of cooking oil for deep frying of food, as it can be linked to the cause of diseases like cancer. The over-usage of cooking oil in the preparation of food is therefore strictly regulated by laws worldwide.

The UFS-research doesn’t only show that over-used cooking oil is harmful to micro-organisms like yeast, but also suggests how nanotechnology can be used in biological and medical research on, amongst others, cancer cells.

Figure 1. Yeast cells exposed to over-used cooking oil. Wart like protuberances/ outgrowths (WP) is clearly visible on the surfaces of the elongated yeast cells. With the use of nanotechnology, it is possible to peel off the warts – some with a diameter of only a few nanometres – in layers only a few nanometres thick. At the same time, the 3D-structure of the warts as well as its chemical composition can be established.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za
18 August 2010

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