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Innovation in infrastructure development

16 January 2024 | Story Leonie Bolleurs

The university is transforming its campus with state-of-the-art infrastructure development. We are creating spaces that foster learning, empower groundbreaking research, and offer an enriching university experience.

UFS Sasol Library

The UFS has been hard at work to move away from traditional library spaces towards creating tech-enhanced, flexible environments that are dynamic for teaching and learning. According to Jeannet Molopyane, Director of Library and Information Services, they strive to align their spaces with global best practices with the infrastructure changes.

Centre for Mineral Biogeochemistry

The Centre for Mineral Biogeochemistry – completed in February 2023 – integrates seamlessly with its surrounding environment, while also providing a new collaborative workspace for the centre’s personnel. This state-of-the-art facility boasts various laboratories which were mainly funded by the Department of Science and Innovation (DSI). The CMBG includes, among other initiatives, the Mineral Node of the Biogeochemistry Research Infrastructure Platform (BIOGRIP), an initiative of the DSI. This space is situated next to the existing Microbiology Building on the Bloemfontein Campus.

University Estates Building

For this repair and renovation project, with a construction theme, internal and external materials were selected for their low-maintenance qualities. The first office, located opposite the entrance door, features cladding with exposed galvanised corrugated iron. A new steel mezzanine level was installed and painted in ‘CAT’ yellow and black. All pipes, including plumbing and electrical, are exposed on wall surfaces. The use of internal exposed brickwork, concrete floors, and oriented strand board in ceilings and cupboards further accents this quality in the completed project.

Animal Research Centre

The Animal Research Centre on the Qwaqwa Campus, replaced the temporary structure that previously served as animal housing. The new structure complies with the requirements and standards for a research facility and caters to the needs of researchers and animals, including small and large rodents. The exterior materials used complement those of the surrounding buildings, providing a low-maintenance profile. The building, accessible to persons with disabilities, contains two research laboratories, an ecotoxicology laboratory, a veterinarian’s office, and a procedure room.

South Campus 24/7 Study Space

The shift to extended programmes and dramatic increase in student enrolment on the South Campus created the need for additional study areas. Considering the steep site outcrop and the existing pedestrian routes from the lower campus, the design explored building blocks that progressively staggered up the hill to accommodate a small amphitheatre study area, maximising seating capacity. This allows the building to accommodate the site’s steepness rather than ignore it. The final design provides study spaces on three levels, all accessible via a ramp, with the main functions situated on the primary level. This design also ensures accessibility for all users, including those with disabilities.

KovsieGear

Incline Architects has designed a new innovative space on the Thakaneng Bridge on the Bloemfontein Campus to accommodate the expansion of the KovsieGear outlet. This new design incorporates extra retail space along with additional room for administration work. The KovsieGear shop now features a new aesthetic, created with natural materials to complement the UFS colours.

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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