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18 June 2024 | Story André Damons | Photo Suplied
SADoCoL
Betsie Human and Elandré Williams, analysts at the South African Doping Control Laboratory (SADoCoL) at the University of the Free State (UFS), will be involved in sample preparation, analysis and data processing at the upcoming Olympic and Paralympic Games in Paris, France.

Two staff members from the South African Doping Control Laboratory (SADoCoL) which is housed at the University of the Free State (UFS), have been selected to work at the upcoming Olympic and Paralympic Games, in Paris, France.

Elandré Williams and Betsie Human will support the Paris laboratory during both games. The Olympic Games will take place from 26 July to 11 August 2024 and the Paralympic Games from 28 August to 8 September 2024.

Williams will be involved in steroid profile analysis, which includes sample preparation, analysis and data processing by Gas Chromatography (GC) and Isotope Ratio Mass Spectrometry (GC-C-IRMS).

Part of the fight against doping 

“I am excited, optimistic and privileged to have been given this opportunity, but I have to say that I am also quite nervous as this is most probably the biggest sporting event of the year. Being a part of the fight against doping in sport remains a great responsibility as what we do directly impacts the athletes,” says Williams.

She says is looking forward to the entire experience, from doing what she loves on an international level, meeting other analysts in the field and being part of the fight against doping in sport on an Olympic level.

This is her first big international sporting event.

“I am also looking forward to learning from other experts in the field who have more experience and to witness the procedures and the manner in which the laboratory operates at this time where the sample numbers are extremely high with the added pressure to finalise results in short turn-around times. This is a great opportunity for growth, both individually and in my field of expertise, in the scientific and the doping control field.

“It will definitely be an advantage for me as an analyst to get exposure to how the entire analytical procedure is executed in another laboratory, as well as insight into possible new techniques and advancements that I will be able to apply back at SADoCoL. I also think this is a great way to improve my ideas, perspectives and level of expertise as I will be working and witnessing other scientific experts in the doping control field.”

Managing workflow and logistics at the Games

Human, who was an analyst at the 2010 Soccer World Cup in South Africa, says she is both nervous and excited for this experience. 

“I was a junior analyst at SADoCoL during the 2010 Soccer World Cup, but you cannot compare a single-sport discipline with a multisport discipline like the Olympic Games – The Games will be exponentially bigger.

“In the past 14 years doping control as a whole has grown significantly. New technologies, updated requirements, more sensitive testing methods have emerged – this will be a new experience,” says Human.

She will also be involved with sample preparation/analysis/data processing and says she is looking forward to seeing how the work-flow and logistics associated with the Games (massive amounts of samples/tight deadlines etc) is managed in a high through-put laboratory.

“I am of course also looking forward to meeting analysts from other labs – we are a bit secluded here at the southern tip of Africa. Collaboration between labs is tricky when your closest neighbour is in Europe.

“It is always eye-opening to see how other labs manage similar situations (even though an Olympics is quite different from normal routine days) – exposure to new techniques and alternative thinking has a way of elevating your own thought processes and it promotes growth – both as an individual and as a doping control analyst.”

Immensely proud

Hanno du Preez, Director of SADoCoL, says the laboratory personnel are immensely proud that two of their staff members were chosen to participate in this international event, which for many scientists is the peak of their career. Similarly, this provides acknowledgement to the staff members for the area in which they have been working.

“It is only a select few who are requested to provide service at the Olympic Games. The work conducted in an Olympic laboratory provides experience which cannot be gained elsewhere. The workload and fast-paced analysis is something which the personnel are used to, but the Olympics will bring a different dimension to the processes. 

“We are excited to see what Betsie and Elandré bring back, with regards to new viewpoints on processes which are similar in all anti-doping laboratories. Individual experiences uplift everyone in a regulated business unit such as SADoCoL and also ensures improved relationships between laboratories, as other anti-doping laboratories will be represented at the Games as well. We wish them all the best for the experience, and we thank them for being dedicated ambassadors for SADoCoL and the UFS.”

News Archive

Fight against Ebola virus requires more research
2014-10-22

 

Dr Abdon Atangana
Photo: Ifa Tshishonge
Dr Abdon Atangana, a postdoctoral researcher in the Institute for Groundwater Studies at the University of the Free State (UFS), wrote an article related to the Ebola virus: Modelling the Ebola haemorrhagic fever with the beta-derivative: Deathly infection disease in West African countries.

“The filoviruses belong to a virus family named filoviridae. This virus can cause unembellished haemorrhagic fever in humans and nonhuman monkeys. In literature, only two members of this virus family have been mentioned, namely the Marburg virus and the Ebola virus. However, so far only five species of the Ebola virus have been identified, including:  Ivory Coast, Sudan, Zaire, Reston and Bundibugyo.

“Among these families, the Ebola virus is the only member of the Zaire Ebola virus species and also the most dangerous, being responsible for the largest number of outbreaks.

“Ebola is an unusual, but fatal virus that causes bleeding inside and outside the body. As the virus spreads through the body, it damages the immune system and organs. Ultimately, it causes the blood-clotting levels in cells to drop. This leads to severe, uncontrollable bleeding.

Since all physical problems can be modelled via mathematical equation, Dr Atangana aimed in his research (the paper was published in BioMed Research International with impact factor 2.701) to analyse the spread of this deadly disease using mathematical equations. We shall propose a model underpinning the spread of this disease in a given Sub-Saharan African country,” he said.

The mathematical equations are used to predict the future behaviour of the disease, especially the spread of the disease among the targeted population. These mathematical equations are called differential equation and are only using the concept of rate of change over time.

However, there is several definitions for derivative, and the choice of the derivative used for such a model is very important, because the more accurate the model, the better results will be obtained.  The classical derivative describes the change of rate, but it is an approximation of the real velocity of the object under study. The beta derivative is the modification of the classical derivative that takes into account the time scale and also has a new parameter that can be considered as the fractional order.  

“I have used the beta derivative to model the spread of the fatal disease called Ebola, which has killed many people in the West African countries, including Nigeria, Sierra Leone, Guinea and Liberia, since December 2013,” he said.

The constructed mathematical equations were called Atangana’s Beta Ebola System of Equations (ABESE). “We did the investigation of the stable endemic points and presented the Eigen-Values using the Jacobian method. The homotopy decomposition method was used to solve the resulted system of equations. The convergence of the method was presented and some numerical simulations were done for different values of beta.

“The simulations showed that our model is more realistic for all betas less than 0.5.  The model revealed that, if there were no recovery precaution for a given population in a West African country, the entire population of that country would all die in a very short period of time, even if the total number of the infected population is very small.  In simple terms, the prediction revealed a fast spread of the virus among the targeted population. These results can be used to educate and inform people about the rapid spread of the deadly disease,” he said.

The spread of Ebola among people only occurs through direct contact with the blood or body fluids of a person after symptoms have developed. Body fluid that may contain the Ebola virus includes saliva, mucus, vomit, faeces, sweat, tears, breast milk, urine and semen. Entry points include the nose, mouth, eyes, open wounds, cuts and abrasions. Note should be taken that contact with objects contaminated by the virus, particularly needles and syringes, may also transmit the infection.

“Based on the predictions in this paper, we are calling on more research regarding this disease; in particular, we are calling on researchers to pay attention to finding an efficient cure or more effective prevention, to reduce the risk of contamination,” Dr Atangana said.


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