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21 June 2024 | Story André Damons | Photo Suplied
Dr Claudia Ntsapi
Dr Matlakala C Ntsapi is a Senior Lecturer and researcher in the Department of Basic Medical Sciences at the UFS.

A researcher from the University of the Free State (UFS) is investigating the potential benefits of medicinal plants as supplementary treatments for neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases.

The work of Dr Matlakala Claudia Ntsapi, Senior Lecturer in the Department of Basic Medical Sciences at the UFS, focuses on preserving human brain health to delay or prevent age-related conditions.

According to her, while the primary focus is on age-related neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, the bioactive compounds in these medicinal plants may also have therapeutic potential for other neurological disorders, various types of cancers and Type 2 Diabetes. The broad protective effects of these plant-based bioactive compounds could make them relevant in the potential treatment of other diseases involving oxidative stress and inflammation.

She is involved in several multidisciplinary projects, collaborating with research experts from Denmark, the UK, and various national institutions such as the Central University of Technology (CUT), North West University (NWU), and the Stellenbosch University (SUN), as well as colleagues from the UFS. 

The potential of medicinal plants

“In collaboration with experts from our institution, the CUT and SU, who have strong backgrounds in pharmacology and ethnobotany, we are focusing on underexplored medicinal plants and nutraceuticals. These plants contain bioactive compounds with potential neuroprotective properties, which are believed to provide extra health benefits beyond basic nutritional value,” says Dr Ntsapi.

“We hope that these medicinal plants have the potential to preserve cognitive function and slow the progression of neurodegenerative diseases like Alzheimer’s. Specifically, we aim to identify novel therapeutic targets and discover new avenues for intervention that can improve the quality of life for individuals affected by age-related brain conditions,” she says.

Identifying therapeutic targets and discovering new interventions

The bioactive compounds found in selective medicinal plants and nutraceuticals, explains Dr Ntsapi, serve as a promising source of ‘natural’ therapeutics that may be safer and have fewer side effects compared to conventional synthetic drugs. Additionally, the untapped potential of these compounds for neuroprotection and the preservation of brain health could provide innovative therapeutic solutions. These compounds may be used as complementary therapies to existing drugs, which often have limited efficacy on their own, thereby enhancing overall treatment outcomes for neurodegenerative diseases.

“By utilising cutting-edge techniques, such the innovative CelVivo ClinoStar 2 System, we strive to gain insights into the safety and efficacy of underexplored medicinal plants in preserving cognitive function and slowing disease progression.

“By exploring the untapped potential of bioactive compounds found in medicinal plants and nutraceuticals, our research group aims to contribute to the identification of novel therapeutic targets and the discovery of new avenues for intervention to improve the quality of life for individuals affected by age-related brain conditions,” says Dr Ntsapi.

The researchers, in collaboration with others in the UFS School of Clinical Medicine, will develop 3D cell-based models of the human cortex and hippocampus by utilising the CelVivo ClinoStar 2 System. This cutting-edge technology, housed in an easy-to-use CO² incubator, mimics ‘animal model-like’ conditions with low sheer stress, allowing scientists to generate cell-based models that closely resemble real-world conditions.

Dr Ntsapi explains that they will specifically focus on the technologies’ applications in studying age-related neurodegenerative disorders, such as Alzheimer’s disease. The potential impact of this research is immense, as it could contribute to the development of novel therapeutic strategies for combating the debilitating progression of neurodegenerative diseases, and ultimately improving the quality of life for affected individuals.

Hope for the research

“Our hope for this research is to significantly advance our understanding of neurodegenerative disease progression and to develop novel therapeutic strategies that can effectively combat these debilitating conditions. Ultimately, we aim to improve the quality of life for individuals affected by neurodegenerative diseases by preserving cognitive function and slowing disease progression.

“This research will contribute to the knowledge pool in this field, with the potential to lead to groundbreaking discoveries in the treatment of Alzheimer’s disease and other related disorders, potentially contributing to the policy guidelines on how these conditions are managed and treated,” she says.

The international partners from Denmark and the UK have made their expertise and facilities available to postgraduate students from the UFS, some of whom they are co-supervising.

Dr Ntsapi, who is passionate about exploring innovative solutions to address the gradual decline in normal brain function associated with aging, was this year one the university’s nominations for the prestigious 2023/2024 NSTF-South32 Awards, popularly known as the “Science Oscars” of South Africa. 

News Archive

UFS Safety Awareness March set to create a safe space for students
2017-07-27

 Description: Suspicious behavior Tags: safety, campaign, SRC, communication, awareness


The University of the Free State (UFS), in collaboration with various stakeholders, has dedicated the week of 24 to 28 July 2017 to creating awareness for the safety of students on and around its campuses.

UFS and CUT unite for safety
The highlight of the week will be on Thursday 27 July 2017 when a safety awareness march will take place from the Main Building on the Bloemfontein Campus to the Bram Fischer Building, where a memorandum will be handed over to Mr Sam Mashinini, MEC for Police, Roads, and Transport in the Free State. The march is a partnership between the UFS Student Representative Council (SRC) and the Central University of Technology (CUT).

 During a meeting on 24 July 2017, the Executive Committee of Senate granted formal approval for students and staff of the Bloemfontein Campus to take part in the safety march on 27 July 2017. For this reason, all lectures will be suspended from 11:00 to 13:00 on 27 July 2017 in order to give the campus community the opportunity to participate in the march. Academic staff, as well as staff in the administrative support services, are encouraged to join the march.

Programme for the safety march:


11:00: Marchers gather in front of the Main Building

11:15: Marchers depart from the Main Building to the Main Gate

11:30: Marchers exit the Main Gate and move towards the Central University of Technology (CUT). Students and staff who are unable to participate in the rest of the march, return to their work places or classes.

12:20: UFS and CUT marchers will gather at the Bram Fischer Building, situated on the corner of Nelson Mandela Avenue and Markgraaff Street. Here, the Rector and Vice-Chancellor of the UFS, Prof Francis Petersen, and the Vice-Chancellor and Principal of CUT, Prof Henk de Jager, will address the marchers, after which the memorandum will be read by the respective SRC Presidents and handed to Mr Mashinini.

Activities underway to raise safety awareness
During the week, the Student Representative Council (SRC), together with other stakeholders, have been involved in several activities on and off the Bloemfontein Campus, including door-to-door visits to student homes and residences on and around campus, awareness campaigns at all the gates of the campus, and a Safety Dialogue that will be held on Wednesday 26 July 2017 at the Equitas Auditorium. The aim of the Safety Week is to focus on informing, educating, and encouraging students as well as the Mangaung community at large, in order to work together in creating a safe environment for students.

The week started with the roll-out of an awareness campaign titled Reach Out, which is set to bring students and the community of Mangaung together to help decrease the number of violent crimes faced by students off campus. The communication plan includes safety messages, using outdoor billboards, posters on lampposts around the residential student areas, local community radio stations, campus media, and the university’s social media platforms.

A similar student safety awareness campaign will take place on the university’s Qwaqwa Campus during the week of 31 July 2017.



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