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21 June 2024 | Story André Damons | Photo Suplied
Dr Claudia Ntsapi
Dr Matlakala C Ntsapi is a Senior Lecturer and researcher in the Department of Basic Medical Sciences at the UFS.

A researcher from the University of the Free State (UFS) is investigating the potential benefits of medicinal plants as supplementary treatments for neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases.

The work of Dr Matlakala Claudia Ntsapi, Senior Lecturer in the Department of Basic Medical Sciences at the UFS, focuses on preserving human brain health to delay or prevent age-related conditions.

According to her, while the primary focus is on age-related neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, the bioactive compounds in these medicinal plants may also have therapeutic potential for other neurological disorders, various types of cancers and Type 2 Diabetes. The broad protective effects of these plant-based bioactive compounds could make them relevant in the potential treatment of other diseases involving oxidative stress and inflammation.

She is involved in several multidisciplinary projects, collaborating with research experts from Denmark, the UK, and various national institutions such as the Central University of Technology (CUT), North West University (NWU), and the Stellenbosch University (SUN), as well as colleagues from the UFS. 

The potential of medicinal plants

“In collaboration with experts from our institution, the CUT and SU, who have strong backgrounds in pharmacology and ethnobotany, we are focusing on underexplored medicinal plants and nutraceuticals. These plants contain bioactive compounds with potential neuroprotective properties, which are believed to provide extra health benefits beyond basic nutritional value,” says Dr Ntsapi.

“We hope that these medicinal plants have the potential to preserve cognitive function and slow the progression of neurodegenerative diseases like Alzheimer’s. Specifically, we aim to identify novel therapeutic targets and discover new avenues for intervention that can improve the quality of life for individuals affected by age-related brain conditions,” she says.

Identifying therapeutic targets and discovering new interventions

The bioactive compounds found in selective medicinal plants and nutraceuticals, explains Dr Ntsapi, serve as a promising source of ‘natural’ therapeutics that may be safer and have fewer side effects compared to conventional synthetic drugs. Additionally, the untapped potential of these compounds for neuroprotection and the preservation of brain health could provide innovative therapeutic solutions. These compounds may be used as complementary therapies to existing drugs, which often have limited efficacy on their own, thereby enhancing overall treatment outcomes for neurodegenerative diseases.

“By utilising cutting-edge techniques, such the innovative CelVivo ClinoStar 2 System, we strive to gain insights into the safety and efficacy of underexplored medicinal plants in preserving cognitive function and slowing disease progression.

“By exploring the untapped potential of bioactive compounds found in medicinal plants and nutraceuticals, our research group aims to contribute to the identification of novel therapeutic targets and the discovery of new avenues for intervention to improve the quality of life for individuals affected by age-related brain conditions,” says Dr Ntsapi.

The researchers, in collaboration with others in the UFS School of Clinical Medicine, will develop 3D cell-based models of the human cortex and hippocampus by utilising the CelVivo ClinoStar 2 System. This cutting-edge technology, housed in an easy-to-use CO² incubator, mimics ‘animal model-like’ conditions with low sheer stress, allowing scientists to generate cell-based models that closely resemble real-world conditions.

Dr Ntsapi explains that they will specifically focus on the technologies’ applications in studying age-related neurodegenerative disorders, such as Alzheimer’s disease. The potential impact of this research is immense, as it could contribute to the development of novel therapeutic strategies for combating the debilitating progression of neurodegenerative diseases, and ultimately improving the quality of life for affected individuals.

Hope for the research

“Our hope for this research is to significantly advance our understanding of neurodegenerative disease progression and to develop novel therapeutic strategies that can effectively combat these debilitating conditions. Ultimately, we aim to improve the quality of life for individuals affected by neurodegenerative diseases by preserving cognitive function and slowing disease progression.

“This research will contribute to the knowledge pool in this field, with the potential to lead to groundbreaking discoveries in the treatment of Alzheimer’s disease and other related disorders, potentially contributing to the policy guidelines on how these conditions are managed and treated,” she says.

The international partners from Denmark and the UK have made their expertise and facilities available to postgraduate students from the UFS, some of whom they are co-supervising.

Dr Ntsapi, who is passionate about exploring innovative solutions to address the gradual decline in normal brain function associated with aging, was this year one the university’s nominations for the prestigious 2023/2024 NSTF-South32 Awards, popularly known as the “Science Oscars” of South Africa. 

News Archive

HIV/AIDS could kill 20% of southern Africa’s farm workers by 2020
2008-09-27

HIV / AIDS is claimed to account for 40% - 50% of infections in the workforce in some labor-intensive industries. This means that every farmer will have to replace up to 50% of his workforce within the next 10 years.

This was said by Mrs Estelle Heideman (pictured) of the Faculty of Natural and Agricultural Science at the University of the Free State (UFS) at the launch of a DVD about a project to equip farm workers with knowledge and skills regarding HIV / AIDS.

Mrs Heideman was quoting the research findings of Agrimark Consultant, Johan Willemse, and added that farm workers, because of low literacy levels, remoteness of the areas in which they live and the distances to health care facilities, are often forgotten when it comes to HIV/AIDS prevention and care programmes.

This weekend Mrs Heideman leaves for New York City to take up a scholarship awarded to her by the University of Columbia and the University of California, Los Angeles (UCLA) to participate in the M-A-C AIDS Sponsored Leadership Programme.

The leadership Initiative provides a structured support program to enable participants to exchange best practices in the approach to HIV prevention that can be adapted to local circumstances. At the conclusion of the program the Leadership Initiative will, amongst other benefits, provide funds for Fellows to carry out their prevention program in South Africa.

Such a program was already carried out from February to May this year as part of the Lengau Agri Centre’s Farm Project in collaboration with the Chief Directorate Community Service at the UFS on the farms Slangfontein, Dwarsrivier and Pypersfontein in the Philippolis district.

According to Mrs Heideman, who is the co-coordinator of the project, the aim of this project was to equip farm workers with knowledge and skills regarding HIV/AIDS so that they can take control of their lives and make quality decisions.

“A major advantage of working with farm workers is that the whole family is included in the session and this ensures that all generations get the same message”, she said.

At the end the feedback from the farm workers about the programme was positive. “Many said they had tested for HIV and will continue to do so to ensure that they would be around to see their children grow up”, said Mrs Heideman.

Copies of the DVD can be obtained from Estelle Heideman (0828211230) or Tarryn Nell (0832573843).

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za  
26 September 2008


 

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