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21 June 2024 | Story André Damons | Photo Suplied
Dr Claudia Ntsapi
Dr Matlakala C Ntsapi is a Senior Lecturer and researcher in the Department of Basic Medical Sciences at the UFS.

A researcher from the University of the Free State (UFS) is investigating the potential benefits of medicinal plants as supplementary treatments for neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases.

The work of Dr Matlakala Claudia Ntsapi, Senior Lecturer in the Department of Basic Medical Sciences at the UFS, focuses on preserving human brain health to delay or prevent age-related conditions.

According to her, while the primary focus is on age-related neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, the bioactive compounds in these medicinal plants may also have therapeutic potential for other neurological disorders, various types of cancers and Type 2 Diabetes. The broad protective effects of these plant-based bioactive compounds could make them relevant in the potential treatment of other diseases involving oxidative stress and inflammation.

She is involved in several multidisciplinary projects, collaborating with research experts from Denmark, the UK, and various national institutions such as the Central University of Technology (CUT), North West University (NWU), and the Stellenbosch University (SUN), as well as colleagues from the UFS. 

The potential of medicinal plants

“In collaboration with experts from our institution, the CUT and SU, who have strong backgrounds in pharmacology and ethnobotany, we are focusing on underexplored medicinal plants and nutraceuticals. These plants contain bioactive compounds with potential neuroprotective properties, which are believed to provide extra health benefits beyond basic nutritional value,” says Dr Ntsapi.

“We hope that these medicinal plants have the potential to preserve cognitive function and slow the progression of neurodegenerative diseases like Alzheimer’s. Specifically, we aim to identify novel therapeutic targets and discover new avenues for intervention that can improve the quality of life for individuals affected by age-related brain conditions,” she says.

Identifying therapeutic targets and discovering new interventions

The bioactive compounds found in selective medicinal plants and nutraceuticals, explains Dr Ntsapi, serve as a promising source of ‘natural’ therapeutics that may be safer and have fewer side effects compared to conventional synthetic drugs. Additionally, the untapped potential of these compounds for neuroprotection and the preservation of brain health could provide innovative therapeutic solutions. These compounds may be used as complementary therapies to existing drugs, which often have limited efficacy on their own, thereby enhancing overall treatment outcomes for neurodegenerative diseases.

“By utilising cutting-edge techniques, such the innovative CelVivo ClinoStar 2 System, we strive to gain insights into the safety and efficacy of underexplored medicinal plants in preserving cognitive function and slowing disease progression.

“By exploring the untapped potential of bioactive compounds found in medicinal plants and nutraceuticals, our research group aims to contribute to the identification of novel therapeutic targets and the discovery of new avenues for intervention to improve the quality of life for individuals affected by age-related brain conditions,” says Dr Ntsapi.

The researchers, in collaboration with others in the UFS School of Clinical Medicine, will develop 3D cell-based models of the human cortex and hippocampus by utilising the CelVivo ClinoStar 2 System. This cutting-edge technology, housed in an easy-to-use CO² incubator, mimics ‘animal model-like’ conditions with low sheer stress, allowing scientists to generate cell-based models that closely resemble real-world conditions.

Dr Ntsapi explains that they will specifically focus on the technologies’ applications in studying age-related neurodegenerative disorders, such as Alzheimer’s disease. The potential impact of this research is immense, as it could contribute to the development of novel therapeutic strategies for combating the debilitating progression of neurodegenerative diseases, and ultimately improving the quality of life for affected individuals.

Hope for the research

“Our hope for this research is to significantly advance our understanding of neurodegenerative disease progression and to develop novel therapeutic strategies that can effectively combat these debilitating conditions. Ultimately, we aim to improve the quality of life for individuals affected by neurodegenerative diseases by preserving cognitive function and slowing disease progression.

“This research will contribute to the knowledge pool in this field, with the potential to lead to groundbreaking discoveries in the treatment of Alzheimer’s disease and other related disorders, potentially contributing to the policy guidelines on how these conditions are managed and treated,” she says.

The international partners from Denmark and the UK have made their expertise and facilities available to postgraduate students from the UFS, some of whom they are co-supervising.

Dr Ntsapi, who is passionate about exploring innovative solutions to address the gradual decline in normal brain function associated with aging, was this year one the university’s nominations for the prestigious 2023/2024 NSTF-South32 Awards, popularly known as the “Science Oscars” of South Africa. 

News Archive

UFS establishes a Postgraduate office
2007-07-18

The University of the Free State (UFS) will establish a postgraduate office that will serve as a one-stop service for the co-ordination of academic support services for postgraduate students.

According to the Director: Research Development at the UFS, Prof Frans Swanepoel, the primary purpose of the Postgraduate Office is to provide co-ordination and support services for postgraduate students and postdoctoral fellows, as well as academic staff across the University.

“Guided by values such as intellectual inquiry, innovation, collegiality, integrity and efficiency, the Postgraduate Office will seek to foster a challenging, inclusive and supportive environment for postgraduate teaching, learning, research and scholarship; and will strive to engage students in the vibrant life of a research university”, Prof Swanepoel said.

All sectors of the University, namely students, faculties and staff, stand to benefit from the establishment of this office. Amongst other benefits for these sectors, postgraduate students and postdoctoral research fellows will have their interests promoted in synergy with faculty and departmental facilities. On the other hand, the office will provide a critical resource to the faculties in the form of a single database of postgraduate students, postgraduate topics, supervisors and funding opportunities. Furthermore, it will serve as a useful resource and base for training and information for younger and less experienced staff members.

The establishment of this office will be undertaken in two phases. The first phase will focus on the most critical areas that will make an immediate impact and the second phase on those areas that are not as urgent.

Areas that will be prioritised include the appointment of a manager and co-ordination of stakeholders, the provision of information and communication, useful resources for the UFS, policy administration and monitoring, postgraduate supervisors’ facilitation, recruitment activities, advice and referral, and postgraduate scholarship and bursary management.

The less urgent components of the office will be the development and implementation of academic and professional support programmes, the formation of a research information commons to create an integrated learning environment for postgraduate students, and the development of a postgraduate association or a postgraduate students’ liaison committee to provide a recognised channel of communication between postgraduate students and the University authorities.

The Postgraduate Office will form a vital component of the Directorate Research Development (DRD) at the UFS because of its experience and a noteworthy track record with regard to a facilitative and co-ordinating role that would be essential for the office.

“Establishing the Postgraduate Office as part of the Directorate would give the Centre the necessary links to the research-related issues that are important to most of the postgraduate students at the UFS. Of essential importance will be the linkages with the full spectrum of Strategic Clusters”, Prof Swanepoel explained.

“An important component of the Postgraduate Office will be related to international students and international opportunities for UFS postgraduate students. As the Office for Internationalisation has similarly been placed within the Directorate, the work of the Postgraduate Office will be facilitated by similar placement within the same Directorate”, he concluded.

Media release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@mail.ufs.ac.za  
18 July 2007
 

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