Prof Dirk Opperman obtained his PhD in Biochemistry at the University of the Free State in 2008. This was followed by postdoctoral research on directed evolution with Prof Manfred T Reetz at the Max Planck Institute for Coal Research (Germany). In 2010, he was appointed in the Department of Microbiology and Biochemistry. He subsequently established structural biology at the UFS, and his current research focus lies at the interface of evolutionary and structure-function relationships of biocatalysts, and their application in green chemistry. He is an NRF B-rated researcher with co-authored papers in Science, Nature Communications, and Angewandte Chemie.

His research has been funded by both local and international organisations, ranging from industries such as SASOL to the Global Challenges Research Fund (GCRF, UK). He has a long-standing collaboration with researchers at the Delft University of Technology (TUDelft, the Netherlands) and is currently part of a European Research Area Network Cofund (ERA-NET Cofund) partnership on Food Systems and Climate (FOSC) that develops biocatalysts for upcycling waste.