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27 May 2024 | Story Leonie Bolleurs | Photo Supplied
Inaugural
At the inaugural lecture of Prof Dirk Opperman were, from the left: Prof Opperman, Prof Vasu Reddy, Prof Koos Albertyn, Head of the Department of Microbiology and Biochemistry, and Prof Paul Oberholster, Dean of the Faculty of Natural and Agricultural Sciences.

Prof Dirk Opperman, a distinguished biochemist in the Department of Microbiology and Biochemistry, recently (21 May 2024) delivered his inaugural lecture on the Bloemfontein Campus of the University of the Free State (UFS).

The title of his lecture was: Exploring, Exploiting, and Evolving Life at the Atomic Level.

Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS, welcomed guests, stating, "An inaugural lecture is a major milestone, celebrating a life’s work that culminates in the title of professor. It marks an important chapter in an academic career, with much more to be achieved in the journey of producing important knowledge.”

He believes that an event such as this highlights the university’s pride in the achievements of its academic staff and aligns with Vision 130. “The UFS is proud to host such lectures, as they are significant moments to reveal and showcase the value of excellence in our knowledge pool in research, teaching, and innovation. As a university, we strive to make a difference through groundbreaking work, particularly in addressing society's challenges,” said Prof Reddy, emphasising that this topic truly speaks to the university’s commitment to impactful work in the hard sciences.

Deciphering the unknown

The topic of the lecture captures the essence of Prof Opperman’s research. He explains that ‘exploring’ refers to the determination of the three-dimensional structures of proteins and enzymes. ‘Exploiting’ involves the use of these enzymes to convert substrates into products of value, and ‘evolving’ pertains to mutating the DNA to change the protein, giving it different functions, activities, selectivity, or specificities.

In his lecture, he remarked that if we know the structures of these proteins and enzymes, we can explore what to do with them and how to change them. According to him, there are the unknown knowns, the unknown unknowns, and the known unknowns. “We may know of specific activities and reactions by microorganisms, but we don’t know which enzyme is responsible; similarly, we can know the reactivity of an enzyme, but not necessarily their true physiological functions. I am trying to figure out all these unknowns,” he said.

In his lecture, he also raised the question of whether AI could replace experimental determination of protein structures. "No, not yet; it is only predictions," he believes, commenting that navigating the unknown unknowns is a dangerous place in science.

Establishing the field of structural biology

Prof Opperman, born and raised in the Free State, completed his undergraduate studies at the UFS. Later, in 2008, he obtained his PhD in Biochemistry from the same university. Following his doctoral studies, he conducted postdoctoral research on directed evolution under the guidance of Prof Manfred T Reetz at the Max Planck Institute for Coal Research in Germany, one of the world’s top institutions.

In 2010, he was appointed to the Department of Microbiology and Biochemistry at the UFS, where he has since established the field of structural biology, setting up the infrastructure essential for the advancement thereof. This includes equipment, techniques, and methods for determining the three-dimensional structure of proteins. “It is done using protein crystallisation and then X-ray diffraction,” he explains. Most of these X-ray diffraction experiments are then performed at particle accelerators called synchrotrons, such as Diamond Light Source (UK), which can produce intense X-rays.

His current research explores the interface of evolutionary and structure-function relationships of biocatalysts, with a particular focus on their application in green chemistry. Prof Opperman says that understanding both the structure and the function of an enzyme allows one to manipulate it to perform other functions.

Contributing to the broader goals of sustainable development

One of the projects he is working on highlights the potential for sustainable practices in waste management. Prof Opperman is currently part of a European Research Area Network Cofund partnership on Food Systems and Climate (FOSC), which focuses on developing biocatalysts for upcycling waste. An aspect of this work involves studying enzymes that degrade feathers, thereby converting feather waste into useful products such as fertiliser.

Regarding the contribution of his research to the broader goals of sustainable development and environmental protection, he says that enzymes are the base for biotechnology and the bioeconomy. “They can be sustainably produced, the reactions are environmentally friendly, and the resulting products can be classified as natural. There’s no need to use sources that are not sustainable to extract some of these molecules from,” he explains.

His significant contributions to the field are reflected in more than 50 authored and co-authored papers, some of which are published in prestigious journals such as Science, Nature Communications, and Angewandte Chemie. As an NRF B-rated researcher, his work has received funding from various local and international organisations, including industries such as Sasol and the Global Challenges Research Fund.

News Archive

Louzanne breaks own world record in Switzerland
2017-06-09

Description: Louzanne breaks own world record  Tags: Louzanne breaks own world record

Rufus Botha (left), coach of the athlete Louzanne Coetzee,
went overseas with Coetzee and her guide,
Khothatso Mokone, for a race for the first time.
Coetzee improved her T11 5 000 m world record with more
than 20 seconds in Switzerland.
Photo: Johan Roux

She fought against illness, had to get the green light from medical personnel shortly before her main race, and was very nervous. However, on 5 June 2017, the blind athlete Louzanne Coetzee managed to improve the T11 5 000 m world record with more than 20 seconds.

The Kovsie star’s time of 18:14.27 at the ParAthletics Grand Prix in Nottwil, Switzerland, was approximately 23 seconds faster than her previous world record (18:37.23). In addition, Coetzee, who works at the Institute for Reconciliation and Social Justice at the University of the Free State, also improved the South African T11 800 m record to 2:30.18 on 2 June 2017, and her 4:59.54 on 3 June 2017 in the T11 1 500 m was almost another national record.

Carried by UFS and other support
“One could never be ungrateful when running close to your personal best,” Coetzee said. “Fortunately, with God’s blessing, the support of everybody at home, support from the university, as well as my mom and them, it really was a very blessed and successful event.”

According to her coach, Rufus Botha, Coetzee was not feeling well before the event and had to get medical clearance before the 5 000 m. He told her not to run too hard, even though their goal was 18:20. “She ran an incredible final 600 m, which brought the time down to 18:14,” he said. “It was amazing to watch.”

Botha’s knowledge valuable abroad
He enjoyed going overseas with Coetzee and her guide, Khothatso Mokone, for the first time. “His (Botha’s) experience, knowledge, support, and coaching was extremely valuable,” Coetzee said. “It will definitely help me in future: how to approach things, and everything he shared with us.”

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