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27 May 2024 | Story Leonie Bolleurs | Photo Supplied
Inaugural
At the inaugural lecture of Prof Dirk Opperman were, from the left: Prof Opperman, Prof Vasu Reddy, Prof Koos Albertyn, Head of the Department of Microbiology and Biochemistry, and Prof Paul Oberholster, Dean of the Faculty of Natural and Agricultural Sciences.

Prof Dirk Opperman, a distinguished biochemist in the Department of Microbiology and Biochemistry, recently (21 May 2024) delivered his inaugural lecture on the Bloemfontein Campus of the University of the Free State (UFS).

The title of his lecture was: Exploring, Exploiting, and Evolving Life at the Atomic Level.

Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS, welcomed guests, stating, "An inaugural lecture is a major milestone, celebrating a life’s work that culminates in the title of professor. It marks an important chapter in an academic career, with much more to be achieved in the journey of producing important knowledge.”

He believes that an event such as this highlights the university’s pride in the achievements of its academic staff and aligns with Vision 130. “The UFS is proud to host such lectures, as they are significant moments to reveal and showcase the value of excellence in our knowledge pool in research, teaching, and innovation. As a university, we strive to make a difference through groundbreaking work, particularly in addressing society's challenges,” said Prof Reddy, emphasising that this topic truly speaks to the university’s commitment to impactful work in the hard sciences.

Deciphering the unknown

The topic of the lecture captures the essence of Prof Opperman’s research. He explains that ‘exploring’ refers to the determination of the three-dimensional structures of proteins and enzymes. ‘Exploiting’ involves the use of these enzymes to convert substrates into products of value, and ‘evolving’ pertains to mutating the DNA to change the protein, giving it different functions, activities, selectivity, or specificities.

In his lecture, he remarked that if we know the structures of these proteins and enzymes, we can explore what to do with them and how to change them. According to him, there are the unknown knowns, the unknown unknowns, and the known unknowns. “We may know of specific activities and reactions by microorganisms, but we don’t know which enzyme is responsible; similarly, we can know the reactivity of an enzyme, but not necessarily their true physiological functions. I am trying to figure out all these unknowns,” he said.

In his lecture, he also raised the question of whether AI could replace experimental determination of protein structures. "No, not yet; it is only predictions," he believes, commenting that navigating the unknown unknowns is a dangerous place in science.

Establishing the field of structural biology

Prof Opperman, born and raised in the Free State, completed his undergraduate studies at the UFS. Later, in 2008, he obtained his PhD in Biochemistry from the same university. Following his doctoral studies, he conducted postdoctoral research on directed evolution under the guidance of Prof Manfred T Reetz at the Max Planck Institute for Coal Research in Germany, one of the world’s top institutions.

In 2010, he was appointed to the Department of Microbiology and Biochemistry at the UFS, where he has since established the field of structural biology, setting up the infrastructure essential for the advancement thereof. This includes equipment, techniques, and methods for determining the three-dimensional structure of proteins. “It is done using protein crystallisation and then X-ray diffraction,” he explains. Most of these X-ray diffraction experiments are then performed at particle accelerators called synchrotrons, such as Diamond Light Source (UK), which can produce intense X-rays.

His current research explores the interface of evolutionary and structure-function relationships of biocatalysts, with a particular focus on their application in green chemistry. Prof Opperman says that understanding both the structure and the function of an enzyme allows one to manipulate it to perform other functions.

Contributing to the broader goals of sustainable development

One of the projects he is working on highlights the potential for sustainable practices in waste management. Prof Opperman is currently part of a European Research Area Network Cofund partnership on Food Systems and Climate (FOSC), which focuses on developing biocatalysts for upcycling waste. An aspect of this work involves studying enzymes that degrade feathers, thereby converting feather waste into useful products such as fertiliser.

Regarding the contribution of his research to the broader goals of sustainable development and environmental protection, he says that enzymes are the base for biotechnology and the bioeconomy. “They can be sustainably produced, the reactions are environmentally friendly, and the resulting products can be classified as natural. There’s no need to use sources that are not sustainable to extract some of these molecules from,” he explains.

His significant contributions to the field are reflected in more than 50 authored and co-authored papers, some of which are published in prestigious journals such as Science, Nature Communications, and Angewandte Chemie. As an NRF B-rated researcher, his work has received funding from various local and international organisations, including industries such as Sasol and the Global Challenges Research Fund.

News Archive

Reconciliation ceremony brings a closure to the Reitz incident
2011-02-08

The South African Human Rights Commission (SAHRC) and the University of the Free State (UFS)
are pleased to announce the successful conclusion of the Equality Court complaint against the four
former UFS students for their recording and dissemination of a video which demeaned and
humiliated five university workers in 2007.

The closure of the complaint culminated tonight in a moving reconciliation ceremony held on the
Main Campus of the UFS in Bloemfontein. The key event of the evening included the reading of
messages of apology from Prof. Teuns Verschoor, Vice-Rector, on behalf of the institution, and Mr
Danie Grobler, on behalf of the former students; and a message of acceptance of the apologies
from Ms Emmah Koko on behalf of the workers.

Deputy Chairperson of the SAHRC Commissioner, Pregs Govender, said of this historic event:
“The courage and compassion shown by the workers together with the students’ willingness to
embrace the spirit of change have enabled a process of justice, transformation and reconciliation
that is an inspiring example for South Africa. The process, led by Prof. Jonathan Jansen, Vice-
Chancellor and Rector of the UFS, whose term began just after this incident, has laid a significant
foundation for the future. It is significant, not just for this university, but for all educational
institutions, including schools.”

“The ceremony of apology, forgiveness, and reconciliation represents a historic event – not only for
our campus, but also for the country. It lays the groundwork for building a new university culture and
climate. “Reitz” hurt all of us, and we can finally close the book on the past and rebuild our
institution to be a truly non-racial university where we respect each other, first and foremost, for our
common humanity,” said Prof. Jansen.

Messages from among others former President Nelson Mandela, Archbishop Emeritus Desmond
Tutu, and the Presidency, were also read.

The day started off with a seminar on reconciliation, hosted by the SAHRC, UFS and the Mangaung
Local Municipality. Former Chief Justice Pius Langa was the keynote speaker at this event. Other
participants in the seminar included Mr Lawrence Mushwana, Chairperson of the SAHRC; Mr Wally
Serote from the Freedom Park; and Mr John Samuel, Director of the International Institute for
Studies in Race, Reconciliation and Social Justice at the UFS.


Media Release
25 February 2011
Issued by: Lacea Loader
Director: Strategic Communication
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

 

 

 

 

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