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27 May 2024 | Story Leonie Bolleurs | Photo Supplied
Inaugural
At the inaugural lecture of Prof Dirk Opperman were, from the left: Prof Opperman, Prof Vasu Reddy, Prof Koos Albertyn, Head of the Department of Microbiology and Biochemistry, and Prof Paul Oberholster, Dean of the Faculty of Natural and Agricultural Sciences.

Prof Dirk Opperman, a distinguished biochemist in the Department of Microbiology and Biochemistry, recently (21 May 2024) delivered his inaugural lecture on the Bloemfontein Campus of the University of the Free State (UFS).

The title of his lecture was: Exploring, Exploiting, and Evolving Life at the Atomic Level.

Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS, welcomed guests, stating, "An inaugural lecture is a major milestone, celebrating a life’s work that culminates in the title of professor. It marks an important chapter in an academic career, with much more to be achieved in the journey of producing important knowledge.”

He believes that an event such as this highlights the university’s pride in the achievements of its academic staff and aligns with Vision 130. “The UFS is proud to host such lectures, as they are significant moments to reveal and showcase the value of excellence in our knowledge pool in research, teaching, and innovation. As a university, we strive to make a difference through groundbreaking work, particularly in addressing society's challenges,” said Prof Reddy, emphasising that this topic truly speaks to the university’s commitment to impactful work in the hard sciences.

Deciphering the unknown

The topic of the lecture captures the essence of Prof Opperman’s research. He explains that ‘exploring’ refers to the determination of the three-dimensional structures of proteins and enzymes. ‘Exploiting’ involves the use of these enzymes to convert substrates into products of value, and ‘evolving’ pertains to mutating the DNA to change the protein, giving it different functions, activities, selectivity, or specificities.

In his lecture, he remarked that if we know the structures of these proteins and enzymes, we can explore what to do with them and how to change them. According to him, there are the unknown knowns, the unknown unknowns, and the known unknowns. “We may know of specific activities and reactions by microorganisms, but we don’t know which enzyme is responsible; similarly, we can know the reactivity of an enzyme, but not necessarily their true physiological functions. I am trying to figure out all these unknowns,” he said.

In his lecture, he also raised the question of whether AI could replace experimental determination of protein structures. "No, not yet; it is only predictions," he believes, commenting that navigating the unknown unknowns is a dangerous place in science.

Establishing the field of structural biology

Prof Opperman, born and raised in the Free State, completed his undergraduate studies at the UFS. Later, in 2008, he obtained his PhD in Biochemistry from the same university. Following his doctoral studies, he conducted postdoctoral research on directed evolution under the guidance of Prof Manfred T Reetz at the Max Planck Institute for Coal Research in Germany, one of the world’s top institutions.

In 2010, he was appointed to the Department of Microbiology and Biochemistry at the UFS, where he has since established the field of structural biology, setting up the infrastructure essential for the advancement thereof. This includes equipment, techniques, and methods for determining the three-dimensional structure of proteins. “It is done using protein crystallisation and then X-ray diffraction,” he explains. Most of these X-ray diffraction experiments are then performed at particle accelerators called synchrotrons, such as Diamond Light Source (UK), which can produce intense X-rays.

His current research explores the interface of evolutionary and structure-function relationships of biocatalysts, with a particular focus on their application in green chemistry. Prof Opperman says that understanding both the structure and the function of an enzyme allows one to manipulate it to perform other functions.

Contributing to the broader goals of sustainable development

One of the projects he is working on highlights the potential for sustainable practices in waste management. Prof Opperman is currently part of a European Research Area Network Cofund partnership on Food Systems and Climate (FOSC), which focuses on developing biocatalysts for upcycling waste. An aspect of this work involves studying enzymes that degrade feathers, thereby converting feather waste into useful products such as fertiliser.

Regarding the contribution of his research to the broader goals of sustainable development and environmental protection, he says that enzymes are the base for biotechnology and the bioeconomy. “They can be sustainably produced, the reactions are environmentally friendly, and the resulting products can be classified as natural. There’s no need to use sources that are not sustainable to extract some of these molecules from,” he explains.

His significant contributions to the field are reflected in more than 50 authored and co-authored papers, some of which are published in prestigious journals such as Science, Nature Communications, and Angewandte Chemie. As an NRF B-rated researcher, his work has received funding from various local and international organisations, including industries such as Sasol and the Global Challenges Research Fund.

News Archive

UFS Rose Ball promises to be an unforgettable experience
2005-09-08

On Saturday 15 of October 2005, the Department of Paediatrics and Child Health at the University of the Free State (UFS) in collaboration with Medi-Clinic, are hosting a Rose Ball in aid of children and babies with serious diseases and special needs.

The Bloemfontein public should get ready for one of the most magnificent events ever held in the city. 

The Rose Ball promises to offer an evening of glamour, elegance and beauty which will make it an unforgettable and unique event.  The Department aims to make the Rose Ball an annual event to which the Bloemfontein public can look forward to with expectation.

“Excellent food and wine, a 35 man symphony orchestra and of course a magical setting awaits those who attend the Rose Ball.  We will do everything possible to make guests feel special, so that they return to the Rose Ball year after year.  In this way, we can ensure an annual income from this event for children and babies who are very ill and need specialised care,” said Prof. André Venter, Head of the Department of Paediatrics and Child Health.

The Department of Paediatrics and Child Health at the UFS is responsible for the tertiary care, that is highly specialised care, of around 1 000 000 children in the Free State, Northern Cape, North-West, Eastern Cape and Lesotho.  Approximately 13 000 out-patients are treated at the Universitas and Pelonomi Hospitals annually.  Children who suffer from cancer, heart disease, neurological disease and endocrinological and gastro-enterological conditions are treated.  The Department is also responsible for children who need intensive care and children with contagious diseases.  In addition, there is a large neonatal unit where prematurely born babies are treated.

The level of health care needed to treat these children and babies, necessitate highly specialised equipment and knowledge.  However, it is not always possible to replace or upgrade equipment, due to the lack of much-needed funds.  That is why a fund was created within the Department to satisfy the need for funds. The Rose Ball promises to eventually give a vital boost to the fund that will go a long way toward providing in the special healthcare needs of these patients.

The Rose Ball is made possible thanks to the support of Medi-Clinic.

“Medi-Clinic is honoured to be involved in this great effort and in this way take hands with the Department of Paediatrics and Child Health at the UFS.  There are so many children with life-threatening diseases today and we cannot afford to be uninvolved in any effort to make life better and easier for these children.  We at Medi-Clinic, as a private sector company, look forward to establishing a long-term commitment with the Department of Paediatrics and Child Health,” said Mr Sakkie van der Merwe, Hospital Manager of Bloemfontein Medi-Clinic.

Only a limited number of tables are still available for the Rose Ball.  Tickets cost R500 per person or R5 000 per table of 10 people. 

Those who are interested can contact Ms Ilse Olivier at 051-4012415 or Ms Adele van Aswegen at 051-4013535 for more information.

Media release
Issued by:  Lacea Loader
   Media Representative
   Tel:  (051) 401-2584
   Cell:  083 645 2454
   E-mail:  loaderl.stg@mail.uovs.ac.za
8 September 2005
 

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