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27 May 2024 | Story Leonie Bolleurs | Photo Supplied
Inaugural
At the inaugural lecture of Prof Dirk Opperman were, from the left: Prof Opperman, Prof Vasu Reddy, Prof Koos Albertyn, Head of the Department of Microbiology and Biochemistry, and Prof Paul Oberholster, Dean of the Faculty of Natural and Agricultural Sciences.

Prof Dirk Opperman, a distinguished biochemist in the Department of Microbiology and Biochemistry, recently (21 May 2024) delivered his inaugural lecture on the Bloemfontein Campus of the University of the Free State (UFS).

The title of his lecture was: Exploring, Exploiting, and Evolving Life at the Atomic Level.

Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS, welcomed guests, stating, "An inaugural lecture is a major milestone, celebrating a life’s work that culminates in the title of professor. It marks an important chapter in an academic career, with much more to be achieved in the journey of producing important knowledge.”

He believes that an event such as this highlights the university’s pride in the achievements of its academic staff and aligns with Vision 130. “The UFS is proud to host such lectures, as they are significant moments to reveal and showcase the value of excellence in our knowledge pool in research, teaching, and innovation. As a university, we strive to make a difference through groundbreaking work, particularly in addressing society's challenges,” said Prof Reddy, emphasising that this topic truly speaks to the university’s commitment to impactful work in the hard sciences.

Deciphering the unknown

The topic of the lecture captures the essence of Prof Opperman’s research. He explains that ‘exploring’ refers to the determination of the three-dimensional structures of proteins and enzymes. ‘Exploiting’ involves the use of these enzymes to convert substrates into products of value, and ‘evolving’ pertains to mutating the DNA to change the protein, giving it different functions, activities, selectivity, or specificities.

In his lecture, he remarked that if we know the structures of these proteins and enzymes, we can explore what to do with them and how to change them. According to him, there are the unknown knowns, the unknown unknowns, and the known unknowns. “We may know of specific activities and reactions by microorganisms, but we don’t know which enzyme is responsible; similarly, we can know the reactivity of an enzyme, but not necessarily their true physiological functions. I am trying to figure out all these unknowns,” he said.

In his lecture, he also raised the question of whether AI could replace experimental determination of protein structures. "No, not yet; it is only predictions," he believes, commenting that navigating the unknown unknowns is a dangerous place in science.

Establishing the field of structural biology

Prof Opperman, born and raised in the Free State, completed his undergraduate studies at the UFS. Later, in 2008, he obtained his PhD in Biochemistry from the same university. Following his doctoral studies, he conducted postdoctoral research on directed evolution under the guidance of Prof Manfred T Reetz at the Max Planck Institute for Coal Research in Germany, one of the world’s top institutions.

In 2010, he was appointed to the Department of Microbiology and Biochemistry at the UFS, where he has since established the field of structural biology, setting up the infrastructure essential for the advancement thereof. This includes equipment, techniques, and methods for determining the three-dimensional structure of proteins. “It is done using protein crystallisation and then X-ray diffraction,” he explains. Most of these X-ray diffraction experiments are then performed at particle accelerators called synchrotrons, such as Diamond Light Source (UK), which can produce intense X-rays.

His current research explores the interface of evolutionary and structure-function relationships of biocatalysts, with a particular focus on their application in green chemistry. Prof Opperman says that understanding both the structure and the function of an enzyme allows one to manipulate it to perform other functions.

Contributing to the broader goals of sustainable development

One of the projects he is working on highlights the potential for sustainable practices in waste management. Prof Opperman is currently part of a European Research Area Network Cofund partnership on Food Systems and Climate (FOSC), which focuses on developing biocatalysts for upcycling waste. An aspect of this work involves studying enzymes that degrade feathers, thereby converting feather waste into useful products such as fertiliser.

Regarding the contribution of his research to the broader goals of sustainable development and environmental protection, he says that enzymes are the base for biotechnology and the bioeconomy. “They can be sustainably produced, the reactions are environmentally friendly, and the resulting products can be classified as natural. There’s no need to use sources that are not sustainable to extract some of these molecules from,” he explains.

His significant contributions to the field are reflected in more than 50 authored and co-authored papers, some of which are published in prestigious journals such as Science, Nature Communications, and Angewandte Chemie. As an NRF B-rated researcher, his work has received funding from various local and international organisations, including industries such as Sasol and the Global Challenges Research Fund.

News Archive

Esteemed Tutu family honorary guests at first intercontinental symposium
2013-10-08

 

08 October 2013
Photo: Karina Turok

The University of the Free State (UFS) will be hosting a visit by Archbishop Desmond Tutu and Mrs Leah Tutu. The occasion is to launch the Annual Intercontinental Leah Tutu Symposium on rape and violence against women in honour of Mrs Tutu, who has been an outspoken advocate of women’s rights and the sanctity of family life.

The Inaugural Intercontinental Leah Tutu Symposium will take place on:

Thursday 17 October 2013
12:00-14:00
Scaena Theatre


The launch of the Annual Intercontinental Leah Tutu Symposium is organised by Profs Pumla Gobodo-Madikizela (who hosts the Dialogue between Science and Society lecture series) and Heidi Hudson (Director of the Centre for Africa Studies). The Inaugural Intercontinental Leah Tutu Symposium will feature gender and policy analyst Nomboniso Gasa as keynote speaker and Sheila Meintjes, Wits University professor with expertise in gender politics, violence and conflict transformation. The event will also feature voices of survivors of rape and sexual violence, including Johannesburg businesswoman and social entrepreneur, Andy Kawa, who is a survivor of rape and started the organisation Enuf is Enuf to campaign for an end to rape and sexual violence.

On Mrs Tutu’s 80th birthday, during the family’s visit to the UFS, Archbishop Desmond Tutu will also be in conversation with the Vice-Chancellor and Rector, Prof Jonathan Jansen, at a public event: Celebration of a partnership: Archbishop Tutu pays tribute to his wife, on the topic: Man to Man: The Meaning of Leah in My Life.

Thursday 17 October 2013
16:30-18:00
Centenary Complex


The public event is part of the Dialogue between Science and Society lecture series, in collaboration with Mrs Grace Jansen and the Tutu Legacy Foundation.

Please RSVP to Anja Pienaar at pienaaran@ufs.ac.za or +27(0)51 401 7330 or Jo-Anne Naidoo at naidooja@ufs.ac.za or +27(0)51 401 7160.

Two of their daughters, Rev Mpho Tutu and Dr Thandeka Tutu-Gxashe, will accompany Archbishop Desmond and Mrs Leah Tutu.

Short Bio of Mrs Leah Tutu

Nomalizo Leah Tutu is an outspoken advocate for the rights of women and the sanctity of family life. She was awarded an Honorary Doctorate in 2000 by the National Louis University in Atlanta for her commitment to human rights and support of her husband’s work. She is patron of the Phelophepa Train, a health project that brings medical care to people living in remote areas of South Africa. She is also a patron of the Tshwaranang Centre that provides legal advocacy to end violence against women. With Archbishop Tutu, Mrs Tutu is a patron of the Tygerberg Children’s Hospital in Cape Town. She, Archbishop Tutu, and family established the Desmond and Leah Tutu Legacy Foundation in 2012.

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