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27 May 2024 | Story Leonie Bolleurs | Photo Supplied
Inaugural
At the inaugural lecture of Prof Dirk Opperman were, from the left: Prof Opperman, Prof Vasu Reddy, Prof Koos Albertyn, Head of the Department of Microbiology and Biochemistry, and Prof Paul Oberholster, Dean of the Faculty of Natural and Agricultural Sciences.

Prof Dirk Opperman, a distinguished biochemist in the Department of Microbiology and Biochemistry, recently (21 May 2024) delivered his inaugural lecture on the Bloemfontein Campus of the University of the Free State (UFS).

The title of his lecture was: Exploring, Exploiting, and Evolving Life at the Atomic Level.

Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS, welcomed guests, stating, "An inaugural lecture is a major milestone, celebrating a life’s work that culminates in the title of professor. It marks an important chapter in an academic career, with much more to be achieved in the journey of producing important knowledge.”

He believes that an event such as this highlights the university’s pride in the achievements of its academic staff and aligns with Vision 130. “The UFS is proud to host such lectures, as they are significant moments to reveal and showcase the value of excellence in our knowledge pool in research, teaching, and innovation. As a university, we strive to make a difference through groundbreaking work, particularly in addressing society's challenges,” said Prof Reddy, emphasising that this topic truly speaks to the university’s commitment to impactful work in the hard sciences.

Deciphering the unknown

The topic of the lecture captures the essence of Prof Opperman’s research. He explains that ‘exploring’ refers to the determination of the three-dimensional structures of proteins and enzymes. ‘Exploiting’ involves the use of these enzymes to convert substrates into products of value, and ‘evolving’ pertains to mutating the DNA to change the protein, giving it different functions, activities, selectivity, or specificities.

In his lecture, he remarked that if we know the structures of these proteins and enzymes, we can explore what to do with them and how to change them. According to him, there are the unknown knowns, the unknown unknowns, and the known unknowns. “We may know of specific activities and reactions by microorganisms, but we don’t know which enzyme is responsible; similarly, we can know the reactivity of an enzyme, but not necessarily their true physiological functions. I am trying to figure out all these unknowns,” he said.

In his lecture, he also raised the question of whether AI could replace experimental determination of protein structures. "No, not yet; it is only predictions," he believes, commenting that navigating the unknown unknowns is a dangerous place in science.

Establishing the field of structural biology

Prof Opperman, born and raised in the Free State, completed his undergraduate studies at the UFS. Later, in 2008, he obtained his PhD in Biochemistry from the same university. Following his doctoral studies, he conducted postdoctoral research on directed evolution under the guidance of Prof Manfred T Reetz at the Max Planck Institute for Coal Research in Germany, one of the world’s top institutions.

In 2010, he was appointed to the Department of Microbiology and Biochemistry at the UFS, where he has since established the field of structural biology, setting up the infrastructure essential for the advancement thereof. This includes equipment, techniques, and methods for determining the three-dimensional structure of proteins. “It is done using protein crystallisation and then X-ray diffraction,” he explains. Most of these X-ray diffraction experiments are then performed at particle accelerators called synchrotrons, such as Diamond Light Source (UK), which can produce intense X-rays.

His current research explores the interface of evolutionary and structure-function relationships of biocatalysts, with a particular focus on their application in green chemistry. Prof Opperman says that understanding both the structure and the function of an enzyme allows one to manipulate it to perform other functions.

Contributing to the broader goals of sustainable development

One of the projects he is working on highlights the potential for sustainable practices in waste management. Prof Opperman is currently part of a European Research Area Network Cofund partnership on Food Systems and Climate (FOSC), which focuses on developing biocatalysts for upcycling waste. An aspect of this work involves studying enzymes that degrade feathers, thereby converting feather waste into useful products such as fertiliser.

Regarding the contribution of his research to the broader goals of sustainable development and environmental protection, he says that enzymes are the base for biotechnology and the bioeconomy. “They can be sustainably produced, the reactions are environmentally friendly, and the resulting products can be classified as natural. There’s no need to use sources that are not sustainable to extract some of these molecules from,” he explains.

His significant contributions to the field are reflected in more than 50 authored and co-authored papers, some of which are published in prestigious journals such as Science, Nature Communications, and Angewandte Chemie. As an NRF B-rated researcher, his work has received funding from various local and international organisations, including industries such as Sasol and the Global Challenges Research Fund.

News Archive

Launch of the Africa office of the IIDE
2006-05-25

Attending the launch of the Africa office of the IIDE were from the left Prof Sytse Strijbos (Chairperson of IIDE Europe), Rev Kiepie Jaftha (Chairperson of the IIDE in Africa’s Board of Directors and Chief Director: Community Service at the UFS) and Prof Frederick Fourie (Rector and Vice-Chancellor of the UFS).

 

Attending the launch were from the left Prof Lucius Botes (Director: Centre of Development Support at the UFS), Dr Samuel Kareithi (Head: Community Development at the Cornerstone Christian College, Cape Town), Rev Kiepie Jaftha (Chairperson of the IIDE in Africa’s Board of Directors and Chief Director: Community Service at the UFS), Prof Sytse Strijbos (Chairperson of IIDE Europe) and Dr Ezekiel Moraka (Vice-Rector:  Student Affairs at the UFS).

Africa office of IIDE launched on UFS main campus 

The Africa office of the International Institute for Development and Ethics (IIDE) was today (26 May 2006) launched on the Main Campus of the University of the Free State (UFS) in Bloemfontein.

“The IIDE specialises in the studying and research of general questions of developmental theory and practices and provides services and support in education, strategic planning, policy formulation, advocacy and capacity building of development agencies,” said Rev Kiepie Jaftha, Chairperson of the IIDE in Africa’s Board of Directors and Chief Director: Community Service at the UFS.

According to Rev Jaftha the IIDE in Africa will focus on the conceptual and normative aspects of developmental processes in Sub-Saharan Africa.  “We want to foster local and international partnerships with various relevant role-players in civil society, the private sector and public sector in the SACD region and later expand our operations to the rest of Africa,” said Rev Jaftha.

The IIDE in Africa cooperates with a similar foundation in Europe, functioning as the IIDE Europe.  This institute was founded in 2003 and its head office is situated in the Netherlands.  The UFS is a funder of the IIDE in Africa together with the Paul Foundation and private sponsors from the Netherlands.

“We have already started with various projects which are in various stages of implementation,” said Rev Jaftha.  Some of these projects include, among others, the broadening of the master’s degree in Christian Studies of Science and Society (MACSSS) which is currently housed at the Vrije Universiteit in Amsterdam to tertiary institutions in South Africa such as the UFS, the University of Stellenbosch and the Potchefstroom Campus of the Northwest University.

“Another project is an investigation into the possibility of initiating a broad development initiative in the poverty stricken Qwaqwa area.  This initiative will attempt to concentrate on issues like the training and empowerment of prospective entrepreneurs in the region, the identification of prospective entrepreneurs for the rendering of development support and the monitoring of the impact of information and communication technology on local communities during the implementation of sustainable development initiatives,” said Rev Jaftha.

“The establishment of the Africa office of the IIDE on the UFS Main Campus is an indication of one of the aims of the UFS to play a role in South Africa and Africa.  It also signifies our aim to contribute meaningfully to research and development and to establish links between the academe and practice,” said Rev Jaftha. 

 

Media release
Issued by: Lacea Loader
Media Representative
Tel:   (051) 401-2584
Cell:  083 645 2454
E-mail:  loaderl.stg@mail.uovs.ac.za
26 May 2006

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