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27 May 2024 | Story Leonie Bolleurs | Photo Supplied
Inaugural
At the inaugural lecture of Prof Dirk Opperman were, from the left: Prof Opperman, Prof Vasu Reddy, Prof Koos Albertyn, Head of the Department of Microbiology and Biochemistry, and Prof Paul Oberholster, Dean of the Faculty of Natural and Agricultural Sciences.

Prof Dirk Opperman, a distinguished biochemist in the Department of Microbiology and Biochemistry, recently (21 May 2024) delivered his inaugural lecture on the Bloemfontein Campus of the University of the Free State (UFS).

The title of his lecture was: Exploring, Exploiting, and Evolving Life at the Atomic Level.

Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS, welcomed guests, stating, "An inaugural lecture is a major milestone, celebrating a life’s work that culminates in the title of professor. It marks an important chapter in an academic career, with much more to be achieved in the journey of producing important knowledge.”

He believes that an event such as this highlights the university’s pride in the achievements of its academic staff and aligns with Vision 130. “The UFS is proud to host such lectures, as they are significant moments to reveal and showcase the value of excellence in our knowledge pool in research, teaching, and innovation. As a university, we strive to make a difference through groundbreaking work, particularly in addressing society's challenges,” said Prof Reddy, emphasising that this topic truly speaks to the university’s commitment to impactful work in the hard sciences.

Deciphering the unknown

The topic of the lecture captures the essence of Prof Opperman’s research. He explains that ‘exploring’ refers to the determination of the three-dimensional structures of proteins and enzymes. ‘Exploiting’ involves the use of these enzymes to convert substrates into products of value, and ‘evolving’ pertains to mutating the DNA to change the protein, giving it different functions, activities, selectivity, or specificities.

In his lecture, he remarked that if we know the structures of these proteins and enzymes, we can explore what to do with them and how to change them. According to him, there are the unknown knowns, the unknown unknowns, and the known unknowns. “We may know of specific activities and reactions by microorganisms, but we don’t know which enzyme is responsible; similarly, we can know the reactivity of an enzyme, but not necessarily their true physiological functions. I am trying to figure out all these unknowns,” he said.

In his lecture, he also raised the question of whether AI could replace experimental determination of protein structures. "No, not yet; it is only predictions," he believes, commenting that navigating the unknown unknowns is a dangerous place in science.

Establishing the field of structural biology

Prof Opperman, born and raised in the Free State, completed his undergraduate studies at the UFS. Later, in 2008, he obtained his PhD in Biochemistry from the same university. Following his doctoral studies, he conducted postdoctoral research on directed evolution under the guidance of Prof Manfred T Reetz at the Max Planck Institute for Coal Research in Germany, one of the world’s top institutions.

In 2010, he was appointed to the Department of Microbiology and Biochemistry at the UFS, where he has since established the field of structural biology, setting up the infrastructure essential for the advancement thereof. This includes equipment, techniques, and methods for determining the three-dimensional structure of proteins. “It is done using protein crystallisation and then X-ray diffraction,” he explains. Most of these X-ray diffraction experiments are then performed at particle accelerators called synchrotrons, such as Diamond Light Source (UK), which can produce intense X-rays.

His current research explores the interface of evolutionary and structure-function relationships of biocatalysts, with a particular focus on their application in green chemistry. Prof Opperman says that understanding both the structure and the function of an enzyme allows one to manipulate it to perform other functions.

Contributing to the broader goals of sustainable development

One of the projects he is working on highlights the potential for sustainable practices in waste management. Prof Opperman is currently part of a European Research Area Network Cofund partnership on Food Systems and Climate (FOSC), which focuses on developing biocatalysts for upcycling waste. An aspect of this work involves studying enzymes that degrade feathers, thereby converting feather waste into useful products such as fertiliser.

Regarding the contribution of his research to the broader goals of sustainable development and environmental protection, he says that enzymes are the base for biotechnology and the bioeconomy. “They can be sustainably produced, the reactions are environmentally friendly, and the resulting products can be classified as natural. There’s no need to use sources that are not sustainable to extract some of these molecules from,” he explains.

His significant contributions to the field are reflected in more than 50 authored and co-authored papers, some of which are published in prestigious journals such as Science, Nature Communications, and Angewandte Chemie. As an NRF B-rated researcher, his work has received funding from various local and international organisations, including industries such as Sasol and the Global Challenges Research Fund.

News Archive

UFS community proud of Wayde’s hat trick of awards
2015-11-24

 

The Kovsie athlete Wayde van Niekerk received a hat trick of awards at the SA Sports Awards on Sunday 22 November 2015. He was named Sports Star of the Year, Sportsman of the Year, and was crowned as winner in the People’s Choice category.
Photo: Charl Devenish

Wayde changed the game – Naidoo

For a long time, AB de Villiers and Chad le Clos have dominated fan support in South Africa, but Wayde van Niekerk changed the game.

This was what Kass Naidoo, well-known sports journalist and cricket commentator, tweeted after the Kovsie athlete, Wayde van Niekerk, made a clean sweep at the tenth SA Sports Awards in his home town, Bloemfontein, on Sunday 22 November 2015.

According to Naidoo, the golden boy from the University of the Free State (UFS) is now the hottest property in South Africa, and should be watched during the 2016 Olympic Games in Rio de Janeiro.

Hat trick for Kovsie athlete
Naidoo was one of several celebrities to congratulate Van Niekerk on Twitter after Wayde received a hat trick of awards in the Sand du Plessis Theatre. The 400 m athlete was named Sports Star of the Year, Sportsman of the Year, and was crowned as winner in the People’s Choice category.

Apart from this, a humble Van Niekerk received total prize money of R1,1 million and two luxury Mercedes Benz vehicles - one for Sports Star of the Year and one as People’s Choice winner.

Big names outperformed
What makes his awards even more remarkable is the fact that he has outperformed several big names.
In addition to De Villiers and Le Clos, the tennis player, Kevin Anderson, the swimmer, Cameron van der Burgh, and the athlete, Caroline Wöstmann, were all nominated for Sports Star of the Year.

For the People’s Choice Award, Van Niekerk beat De Villiers, the cyclist, Ashleigh Moolman-Pasio, (who was crowned Sportswoman of the Year), Le Clos, and the wheelchair tennis player, Lucas Sithole. The public voted for this award.

Le Clos was nominated with the mountain biker, Greg Minnaar, for Sportsman of the Year.

Best is yet to come
“I don't think we have seen the best of Wayde. Hopefully that will come in Rio next year, along with a gold medal,” Naidoo tweeted.

The Springbok winger, JP Pietersen, also congratulated Van Niekerk on the social network, saying that he deserved his award as Sportsman of the Year.

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