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27 May 2024 | Story Leonie Bolleurs | Photo Supplied
Inaugural
At the inaugural lecture of Prof Dirk Opperman were, from the left: Prof Opperman, Prof Vasu Reddy, Prof Koos Albertyn, Head of the Department of Microbiology and Biochemistry, and Prof Paul Oberholster, Dean of the Faculty of Natural and Agricultural Sciences.

Prof Dirk Opperman, a distinguished biochemist in the Department of Microbiology and Biochemistry, recently (21 May 2024) delivered his inaugural lecture on the Bloemfontein Campus of the University of the Free State (UFS).

The title of his lecture was: Exploring, Exploiting, and Evolving Life at the Atomic Level.

Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS, welcomed guests, stating, "An inaugural lecture is a major milestone, celebrating a life’s work that culminates in the title of professor. It marks an important chapter in an academic career, with much more to be achieved in the journey of producing important knowledge.”

He believes that an event such as this highlights the university’s pride in the achievements of its academic staff and aligns with Vision 130. “The UFS is proud to host such lectures, as they are significant moments to reveal and showcase the value of excellence in our knowledge pool in research, teaching, and innovation. As a university, we strive to make a difference through groundbreaking work, particularly in addressing society's challenges,” said Prof Reddy, emphasising that this topic truly speaks to the university’s commitment to impactful work in the hard sciences.

Deciphering the unknown

The topic of the lecture captures the essence of Prof Opperman’s research. He explains that ‘exploring’ refers to the determination of the three-dimensional structures of proteins and enzymes. ‘Exploiting’ involves the use of these enzymes to convert substrates into products of value, and ‘evolving’ pertains to mutating the DNA to change the protein, giving it different functions, activities, selectivity, or specificities.

In his lecture, he remarked that if we know the structures of these proteins and enzymes, we can explore what to do with them and how to change them. According to him, there are the unknown knowns, the unknown unknowns, and the known unknowns. “We may know of specific activities and reactions by microorganisms, but we don’t know which enzyme is responsible; similarly, we can know the reactivity of an enzyme, but not necessarily their true physiological functions. I am trying to figure out all these unknowns,” he said.

In his lecture, he also raised the question of whether AI could replace experimental determination of protein structures. "No, not yet; it is only predictions," he believes, commenting that navigating the unknown unknowns is a dangerous place in science.

Establishing the field of structural biology

Prof Opperman, born and raised in the Free State, completed his undergraduate studies at the UFS. Later, in 2008, he obtained his PhD in Biochemistry from the same university. Following his doctoral studies, he conducted postdoctoral research on directed evolution under the guidance of Prof Manfred T Reetz at the Max Planck Institute for Coal Research in Germany, one of the world’s top institutions.

In 2010, he was appointed to the Department of Microbiology and Biochemistry at the UFS, where he has since established the field of structural biology, setting up the infrastructure essential for the advancement thereof. This includes equipment, techniques, and methods for determining the three-dimensional structure of proteins. “It is done using protein crystallisation and then X-ray diffraction,” he explains. Most of these X-ray diffraction experiments are then performed at particle accelerators called synchrotrons, such as Diamond Light Source (UK), which can produce intense X-rays.

His current research explores the interface of evolutionary and structure-function relationships of biocatalysts, with a particular focus on their application in green chemistry. Prof Opperman says that understanding both the structure and the function of an enzyme allows one to manipulate it to perform other functions.

Contributing to the broader goals of sustainable development

One of the projects he is working on highlights the potential for sustainable practices in waste management. Prof Opperman is currently part of a European Research Area Network Cofund partnership on Food Systems and Climate (FOSC), which focuses on developing biocatalysts for upcycling waste. An aspect of this work involves studying enzymes that degrade feathers, thereby converting feather waste into useful products such as fertiliser.

Regarding the contribution of his research to the broader goals of sustainable development and environmental protection, he says that enzymes are the base for biotechnology and the bioeconomy. “They can be sustainably produced, the reactions are environmentally friendly, and the resulting products can be classified as natural. There’s no need to use sources that are not sustainable to extract some of these molecules from,” he explains.

His significant contributions to the field are reflected in more than 50 authored and co-authored papers, some of which are published in prestigious journals such as Science, Nature Communications, and Angewandte Chemie. As an NRF B-rated researcher, his work has received funding from various local and international organisations, including industries such as Sasol and the Global Challenges Research Fund.

News Archive

Students’ commitment the focus of architectural exhibition at Free State Arts Festival
2016-07-07

Description: Architectural exhibition  Tags: Architectural exhibition

The traveling exhibition of first-year architecture
students of the Nelson Mandela Metropolitan
University consists of 400 exhibition pieces.

Photo: Supplied

A unique travelling exhibition of over 400 pieces will be hosted by the UFS Department of Architecture from 11-23 July 2016. The exhibition, a project of the Nelson Mandela Metropolitan University (NMMU) School of Architecture is the first exhibition of its kind on this scale.

First exhibition of its kind

The architect Boban Varghese, the head of the Department of Architecture at NMMU, said that a series of projects furthering academic engagements are being implemented under his leadership. This travelling exhibition of first-year architecture students is one of these.

The NMMU School of Architecture is engaged in addressing architectural education that is appropriate and relevant as it responds to the contextual challenges shaped by local and global issues.

Students’ work received recognition

Besides being recognition of student work, which is normally confined within the walls of the Schools of Architecture, the aim of the travelling exhibition is not only to introduce the work to students of other Architecture Schools and the architecture profession itself, but also to share the discipline of architecture with a wider public. In this sense, the exhibition is an educational and cultural event.

This important aspect is manifested in the generous support of the UFS Department of Architecture in sponsoring the second exhibition during the Free State Arts Festival, as a collaborative project between two Schools of Architecture. A third exhibition of the work is foreseen in Johannesburg during the annual Architecture Students Congress at Wits later this year.

432 pieces part of research programme

The exhibition PALLADIO AND THE MODERN
is the first exhibition of its kind of first-year
architecture students’ work in South Africa.

The exhibition entitled PALLADIO AND THE MODERN shows the first two projects of the first-year students when they have just arrived from school with little experience in architectural drawings and in building architectural models. Their dedicated commitment to the task of producing 288 drawings and 144 models - a total 432 exhibition pieces - forms part of a three-year research programme (2013-2015) in architectural composition conducted by the Senior Lecturer in Architecture, Ernst Struwig, Dr Magda Minguzzi and Jean-Pierre Basson. All the work exhibited is done by hand.

In the exhibition, the 36 villas of the Renaissance architect, Andrea Palladio (1508-1580), initiate a dialogue with the 36 houses of 20th and 21st international and national architects in their reciprocal theme of exploring the language of architecture.

Visiting hours: Monday to Friday 09:00-16:00
Exhibition closes on 23 July 2016

Sponsors:
Department of Architecture UFS; NMMU; Stauch Vorster Architects; The Matrix Urban Designers and Architects Cc; Adendorff Architects and Interiors Cc; NOH Architects; Thembela Architects (Pty) Ltd; Erik Voight Architects; DMV Architecture, MMK Architects; IMBONO F. J. A. Architects CC; dhk Architects; LYT Architecture; B4 Architects.

 

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