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16 May 2024 | Story Leonie Bolleurs | Photo supplied
Dr Yolandi Schoeman
Dr Yolandi Schoeman believes the project is directly contributing to the regeneration and conservation of biodiversity, innovating towards creating unique urban biodiversity markets, and creating a thriving natural habitat that supports ecological balance and resilience.

Tim Briercliffe, Secretary General of the International Association of Horticultural Producers (AIPH), recently congratulated the City of Tshwane for the work done on urban greening and nature-based solutions that resulted in its entry: ‘Republic of South Africa City of Tshwane Pretoria East Urban Biosphere Reserve’ being selected as one of 21 finalists in the Living Green for Biodiversity category of the AIPH World Green City Awards 2024.

The list of finalists comprises the three highest-scoring entries in each of the seven categories. The Tshwane project was entered in the Living Green for Biodiversity and Urban Ecosystem Restoration category as well as the Living Green for Urban Infrastructure and Liveability category.

Dr Yolandi Schoeman, Postdoctoral Fellow/Researcher in Ecological Engineering in the centres for Mineral Biogeochemistry and Environmental Management and the Ecological Engineering Institute of Africa at the University of the Free State (UFS), played a critical role in conceptualising and driving the bio-intelligent approach that is integral to the Tshwane SA Biosphere Reserve project.

She states that being part of a project recognised as a finalist for such a prestigious global award is profoundly gratifying. “It underscores the importance and urgency of our work in ecological engineering and biodiversity conservation, validating our efforts to create resilient urban ecosystems that can inspire similar initiatives globally.”

Enhancing urban sustainability

According to her, it is one of the university’s flagship projects in Gauteng. “Our team was pivotal in developing the methodological framework that facilitated the integration of ecological, economic, social, and technological dimensions to effectively address climate change, biodiversity loss, disconnections in coupled human and natural systems, and enhance urban sustainability.”

Dr Schoeman says the project was initiated in the early stages of their investigations into sustainable urban development, with notable developments in 2023, as highlighted during the City of Tshwane Climate Change and Research Conference. She indicates that the project is continuing, with phases that include various baseline research activities, active ecosystem regeneration, continuous monitoring, roll-out of a unique biodiversity citizen science approach, integrated and inclusive stakeholder involvement, creating a unique urban biodiversity market, awareness and capacity building, and moving towards formally applying to the International Union for Conservation of Nature (IUCN) for the formal recognition of the urban biosphere region within the greater Pretoria East area.

She remarks that her inspiration to engage in this project stemmed from a commitment to address the multifaceted challenges posed by climate change and biodiversity loss, particularly in urban settings. “The most remarkable aspect of the project is its innovative approach to integrating urban development with ecological engineering, fostering a sustainable coexistence between humans and nature that serves as a model for cities worldwide,” she says.

She is excited about the impact of the work that has been done. Not only is the project directly contributing to the regeneration and conservation of biodiversity, creating a thriving natural habitat that supports ecological balance and resilience, but it is also impacting the greater Tshwane community. Dr Schoeman believes that the project significantly enhances community engagement and participation, which in turn fosters greater awareness and responsibility towards sustainable living practices.

Crafting practical, impactful solutions

Besides her instrumental role in making an impact, Dr Schoeman also enjoyed the project, particularly the opportunity to collaborate with a diverse group of stakeholders, including local communities, government bodies, and fellow researchers. “This multidisciplinary collaboration has not only enriched the project but has also been instrumental in crafting practical, impactful solutions tailored to the specific needs and characteristics of Tshwane,” she comments.

As a finalist in the Living Green for Biodiversity category of the AIPH World Green City Awards 2024, the city of Tshwane will receive a Highly Commended certificate at an awards ceremony in September in Utrecht, the Netherlands, and will ultimately have the opportunity to win the title of Grand Winner of the 2024 edition of the AIPH World Green City Awards.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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