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Advancing Biogeochemistry Research at the UFS

12 November 2024 | Story Jacky Tshokwe | Photo Supplied

Dr Mariana Erasmus (Vice Director, CMBG) demonstrates some of the equipment in the newly established, state-of-the-art laboratories at the Centre for Mineral Biogeochemistry.

The University of the Free State (UFS) recently hosted a landmark event-the national launch of the South African Biogeochemistry Research Infrastructure Platform (BIOGRIP) - in the Centenary Complex on its Bloemfontein Campus. This significant occasion marked the establishment of the Centre for Mineral Biogeochemistry at the UFS and underscored South Africa’s growing commitment to biogeochemistry research.

Prof Anthea Rhoda welcomed the distinguished gathering of scientists, students, industry leaders, and stakeholders, highlighting the launch as a collaborative milestone in South Africa's scientific journey. In her address, Prof Rhoda emphasised the importance of the interdisciplinary nature of biogeochemistry, where biology, geology, and chemistry converge to offer insights into critical issues such as climate change, water quality, and soil health. She remarked on the necessity of collaboration, explaining that BIOGRIP’s platform, built on shared resources and expertise, exemplifies the power of uniting across institutional boundaries to accelerate impactful discoveries.

The programme featured insightful scientific talks by leading experts, each focusing on how biogeochemistry addresses key environmental issues such as sustainability and resource management. These presentations reinforced BIOGRIP’s commitment to advancing knowledge that can influence policy and improve practices.

Attendees were also given guided tours of the state-of-the-art laboratories in the Centre for Mineral Biogeochemistry, which provided a behind-the-scenes look at the advanced tools and methods employed in studying interactions between minerals, biology, and the environment. For many, this was a highlight, as they observed firsthand how biogeochemical research is conducted and contributes to soil health, pollution control, and environmental conservation.

The launch provided ample networking opportunities, fostering connections among academics, government representatives, industry professionals, and environmental organisations. Over a catered lunch, participants engaged in vibrant discussions about potential collaborations and the role of biogeochemistry in addressing South Africa’s environmental challenges.

The BIOGRIP national launch stands as a milestone event, not only for the UFS, but for the broader South African scientific community. With the establishment of this research platform, South Africa is well-positioned to tackle pressing environmental issues through innovative research and cross-sector collaboration. The event left attendees inspired and motivated, setting an optimistic tone for the future of biogeochemistry research in the region.

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Dr Charlotte Boucher and Lindi Heyns examine possible anti-microbial activity in the skin of Western olive toad species

2014-12-22

Researchers Lindi Heyns and Dr Charlotte Boucher are working together on an interdisciplinary project between the Departments of Zoology and Entomology and Veterinary Biotechnology at the University of the Free State (UFS). The focus of their research is on the preliminary biochemical description of skin secretions in some South African toads.

The project forms part of an Honours study executed by Dwayne Pike under Heyns’ supervision. He is co-supervised by Dr Boucher who is assisting with the biochemical and microbiological assays.

Dr Boucher said, “Amphibians are characterised by the presence of cutaneous glands spread over the skin. There are two types of glands, namely mucous and granular (poison), located on the inner surface of the epidermis. Mucous glands are widely dispersed over the skin, while granular glands can be grouped and enlarged in specific regions. Mucous glands are generally associated with maintenance of humidity and cutaneous respiration, whereas granular glands function in chemical defence against predators and/or microbial infection. Studies indicate that the compounds produced by the granular glands belong to numerous chemical classes with diverse pharmacological activities.”

The products secreted by granular glands are rich in low molecular weight constituents of varied molecular types, including proteins, peptides and toxins. These secretions make the toad foul-tasting to predators and even toxic to other frog species. In addition, amphibians offer an attractive source of novel antimicrobials. Studies indicate that as a response to inhabiting microorganism-rich environments they synthesise and secrete a diverse array of antimicrobial peptides (AMPs) as an innate form of defence. Extensive research by various other research groups has been carried out on antimicrobial peptides of the genus Rana; however, hardly any studies have investigated the antimicrobial activity of African frog species.

The focus of this preliminary project is to determine the protein composition of the glandular secretions of the Western olive toad (Amietophrynus poweri), using biochemical tests, such as SDS-PAGE also known as protein gel electrophoresis combined with mass-spectrometry used to identify unknown peptides and proteins. This will give us an overview of the composition of the glandular secretions. Furthermore, we are also looking at microbiological tests, which include assays that test for possible anti-microbial activity against various bacterial and fungal species.

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