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29 November 2024 | Story Prof Mpumelelo Ncube | Photo Supplied
Prof Mpumelelo Ncube
Prof Mpumelelo Ncube is an Associate Professor of Social Work at the University of the Free State.

Opinion article by Prof Mpumelelo Ncube, Head of the Department of Social Work, University of the Free State


As we approach the end of another year, many people take this time to reflect on the successes they have achieved, as well as to appreciate their resilience in overcoming life's challenges. For some, this season of reflection serves as an opportunity to reward themselves for their accomplishments. However, for many others, the festivities become a coping mechanism, masking deeper pain and unresolved trauma.

This year has been marked by several successes, including the simple fact that we are still alive, despite the staggering number of lives lost in the country, but more so, in conflict zones. Countries like Sudan, South Sudan, the Democratic Republic of Congo (DRC), Mozambique, Palestine, and Ukraine have endured severe violence, with countless innocent lives taken. In these instances, the human cost continues to mount, making survival a powerful testament to resilience and divine grace in the face of such overwhelming adversity. Life itself is an accomplishment, but for countless individuals, it also carries untold stories of sorrow, stories not just from this year but from previous years as well. Families continue to grieve the loss of loved ones to the COVID-19 pandemic, and many have lost their livelihoods due to the economic downturn that followed. The situation is further exacerbated by South Africa’s unemployment rate, which exceeds 40% (expanded definition), making it increasingly difficult for many individuals to secure new sources of income.

The violence

In addition, South Africa continues to grapple with violence. Families mourn the loss of loved ones to murder — a pain that never truly heals, though families learn to live with it. The country’s murder rate remains alarmingly high, with slight fluctuations in the past five years looking only at the months of April to June across the years. In 2020, COVID-19 restrictions temporarily reduced murders to 3 466, but once the lockdown lifted, the rate surged to 5 760 in 2021, continuing to rise to 6 424 in 2022. Though slightly declining in 2023 and 2024, the numbers are still far too high. This reflects an ongoing crisis that demands stronger interventions, law enforcement, and efforts to address the socio-economic disparities that fuel crime.

Further compounding the year’s challenges, 2024 saw tragic events such as children dying from poisoned food, mass killings in the Eastern Cape, a rise in extortion, and an alarming increase in teenage pregnancies, especially in underprivileged communities. As we close the year, these issues do not vanish. In fact, they may intensify, often hidden beneath the veneer of holiday festivities.

The impact of alcohol

For many, these festivities are synonymous with alcohol consumption. Despite the economic struggles faced by many, a budget for alcohol remains a priority. This may seem counterintuitive, but it highlights the reality of people using alcohol to escape their suffering. Alcohol, like many other substances, becomes a coping mechanism for the trauma that so many endure.

In its 54th conference, the ANC rightly observed a universal phenomenon of alcohol abuse where socially and economically unequal societies tend to have higher levels of substance abuse, particularly alcohol and drugs. The §National Drug Master Plan 2019/24 identifies alcohol as the primary substance abused across racial and class lines in South Africa, largely due to its easy accessibility, affordability, and cultural associations. South Africa ranks among the high alcohol-consuming countries, with an average of 9.3 litres per capita annually, far surpassing the global average of 6.4 litres.

The consumption of alcohol is particularly concerning among young people, who often gain access to alcohol earlier than legally permitted, especially during the festive season. When young people normalise alcohol consumption, it often leads to lifelong addiction, impaired development, and an inability to fully participate in society. Tragically, in some cases, it results in fatal outcomes.

For the broader population, alcohol is often a catalyst for violence, both in public spaces and within homes. It exacerbates gender-based violence (GBV), fuels broken families, perpetuates cycles of poverty and substance abuse, and undermines social cohesion. These issues have plagued South Africa for years, with little success in addressing them.

The festive season is also associated with a rise in road accidents and fatalities, often linked to alcohol consumption. While this is only the tip of the iceberg, it reflects the broader societal damage caused by alcohol. Yet, alcohol continues to be marketed as a symbol of success, sophistication, and enjoyment. While alcohol-facilitated festivities and social gatherings in general may offer fleeting escapism, they ultimately fail to address the profound psychological and emotional wounds that individuals carry. Beneath the veneer of revelry and glamour, these events often leave participants with unhealed scars, merely postponing the inevitable pursuit of the next escapism opportunity. In truth, the industry exploits vulnerable individuals for profit, often masking the harm it inflicts on communities.

Despite the alcohol industry's substantial contribution to South Africa's GDP, a comprehensive cost-benefit analysis reveals that the industry's socioeconomic costs, encompassing both direct and indirect expenditures, as well as intangible externalities, significantly exceed its economic benefits. In the past, studies have shown that alcohol-related harm costs between 10% and 12% of the country’s GDP, while the benefits, including taxes and employment, account for a less than 10%. This disparity calls for a re-evaluation of the country’s relationship with alcohol. It’s a substance that not only fuels violence and the resulting trauma but also undermines the nation’s aspirations for a more prosperous and equitable future for all. We must question whether alcohol is truly indispensable. Does its social, cultural, or economic significance justify the considerable harm it causes to human life?

16 Days campaign

This truly is the time for the country to reconsider its approach to alcohol regulation. There have been ongoing debates about tightening restrictions on alcohol advertising, with proponents arguing that these measures could mitigate the damage caused by the industry. Some have also called for raising the legal drinking age, suggesting that delaying access to alcohol could benefit both individuals and the economy. Additionally, increasing excise duties could make alcohol less accessible, reducing its harmful impact on society. These steps require leaders who prioritise the lives of the people they serve over the profit margins of corporations. Ultimately, this serves as a clarion call to collective action, urging all stakeholders in society including families, faith-based organisations, community groups, educational institutions, and beyond, to assume a shared responsibility for reversing this destructive trend. By doing so, we can break the cycle of harm, mitigate the pervasive psychological and emotional trauma that permeates our society. Afterall, Life should be treated as sacred and worthy of protection and improvement at every opportunity.

In light of all these issues, we are also reminded of the 16 Days of Activism for No Violence against Women and Children Campaign, a global campaign aimed at raising awareness about violence against women and girls. Let this not be a mere rhetorical exercise, but a call to action, one that demands meaningful decisions and interventions to protect vulnerable individuals and build a society free of violence and harm.

Mpumelelo Ncube is an Associate Professor of Social Work at the University of the Free State. He writes in his personal capacity.

News Archive

Cardiology Unit involved in evaluation of drug for rare genetic disease
2013-01-04

Front from the left, are: Marinda Karsten (study coordinator and registered nurse),
Laumarie de Wet (clinical technologist), Charmaine Krahenbuhl (study coordinator and radiographer),
Lorinda de Meyer (administrator), Andonia Page (study coordinator and enrolled nurse);
back Dr Gideon Visagie (sub investigator), Dr Derick Aucamp (sub investigagtor),
Prof. Hennie Theron, (principal investigator) and Dr Wilhelm Herbst (sub investigator).
Photo: Supplied
09 January 2013


The Cardiology Research Unit at the University of the Free State (UFS) contributed largely to the evaluation of the drug Juxtapid (lomitapide), which was developed by the Aegerion pharmaceutical company and approved by the FDA (Federal Drug Administration). Together with countries such as die USA, Canada and Italy, the UFS’ Unit recruited and evaluated the most patients (5 of 29) for the study since 2008.  

The drug was evaluated in persons with so-called familial homozygous hypercholesterolemia (HoFH).  

Following its approval by the FDA, Juxtapid is now a new treatment option for patients suffering from HoFH. The drug operates in a unique way which brings about dramatic improvements in cholesterol counts.  

According to Prof. Hennie Theron, Associate Professor in the Department of Cardiology at the UFS and Head of the Cardiology Contract Research Unit, HoFH is a serious, rare genetic disease which affects the function of the receptor responsible for the removal of low-density lipoprotein cholesterol (LDL-C) (“bad” cholesterol) from the body. Damage to the LDL receptor function leads to extremely high levels of blood cholesterol. HoFH patients often develop premature and progressive atherosclerosis, which is a narrowing or blockage of the arteries.  

“HoFH is a genetically transmitted disease and the most severe form of hypercholesterolemia. Patients often need a coronary artery bypass or/and aortic valve replacement before the age of 20. Mortality is extremely high and death often occurs before the third decade of life. Existing conventional cholesterol-lowering medication is unsuccessful in achieving normal target cholesterol values in this group of patients.  

“The only modality for treatment is plasmapheresis (similar to dialysis in patients with renal failure). Even with this type of therapy the results are relatively unsatisfactory because it is very expensive and the plasmapheresis has to be performed on a regular basis.  

“The drug Juxtapid, as currently evaluated, has led to a dramatic reduction in cholesterol values and normal values were achieved in several people. No existing drug is nearly as effective.  

“The drug represents a breakthrough in the treatment of familial homozygous hypercholesterolemia. The fact that it has been approved by the FDA, gives further impetus to the findings,” says Prof. Theron.  

In future further evaluation will be performed in other forms of hypocholesterolemia.  

According to Prof. Theron, the findings of the study, as well as the recent successful FDA evaluation, once again confirms the fact that the UFS’ Cardiology Contract Research Unit is doing outstanding work.  

Since its inception in 1992, the Unit has already been involved in more than 60 multi-centre, international phase 2 and 3 drug studies. Several of these studies, including the abovementioned study, really affected the way in which cardiology functions.  

The UFS’ Cardiology Contract Research Unit is being recognised nationally and internationally for its high quality of work and is constantly approached for their involvement in new studies.  

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