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UFS trauma surgeon inducted as American College of Surgeons fellow

04 November 2024 | Story André Damons | Photo Supplied

Dr Emmanuel Arko-Cobbah, Senior Lecturer and Medical Specialist in the Department of Surgery at the University of the Fee State (UFS), says he hopes his induction as a fellow of the American College of Surgeons (ACS), will show the world that South Africa also produces great doctors from whom they can learn.

The ACS is dedicated to improving the care of the surgical patient and safeguarding standards of care in an optimal and ethical practice environment. Dr Arko-Cobbah was inducted on 19 October after a rigorous process. He was part of 1 800 candidates from around the world, but mostly from North America, with about 600 from other countries outside of the US and Canada.

Dr Arko-Cobbah, a trauma surgeon, says it feels surreal as it has always been his dream to become a Fellow of the American College of Surgeons, although it often felt like an impossible dream. “I truly thank God, and I am very grateful, because to me, it feels like it's all part of His plans for me, that is why He is making these things possible for me.

“As a trauma surgeon, it makes me feel I have achieved even beyond our borders, and it gives me the opportunity to also share the knowledge we have locally with the rest of the world. We have a lot to offer, but we tend to get underestimated because of where we’re from,” says Dr Arko-Cobbah.

To become a fellow of the ACS, applicants go through a selection process after applying and then they need to be nominated by three different fellows of the American College who are in good standing. If their nominations get accepted, an interview follows whereafter the reports are reviewed by the committee which then decides the outcome.

South Africa produces great doctors

According to Dr Arko-Cobbah, he hopes to put the UFS on the map with this lifelong fellowship so that the world can know South Africa also produces great doctors and that they can learn from these doctors. “The other side of the coin is for me to inspire others to also aim to get into the American College, and to dream even bigger than this. If I could do this, then anybody can. Partner with God, and dream big dreams, and make big plans. That is what I was taught by Pastor At Boshoff since I was a student, and God has always been faithful.”

After qualifying as doctor and becoming a general surgeon at the UFS, and super specialised as a trauma surgeon, Dr Arko-Cobbah completed a Surgical Leadership Programme with Harvard University in Boston, in the US. “God has always been good to me, and I am forever grateful to the support of my wife and family and continued inspiration and mentorship from Prof André Loubser. I am grateful to the late Prof Theron, and the UFS Surgery Department, past and present, for always pushing me to be better.

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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