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Research chair tackles food insecurity by breeding climate-resilient crops

18 October 2024 | Story André Damons | Photo Supplied

A new research chair at the University of the Free State (UFS), led by Prof Maryke Labuschagne, a Professor of Plant Breeding in the UFS Department of Plant Sciences, hopes to increase food and nutritional security in South Africa through crops that have intrinsic high nutritional value.

The Breeding Climate-Resilient Vegetables and Grains research chair was established in partnership with the Agricultural Research Council (ARC) and the Department of Agriculture, Land Reform and Rural Development (DALRRD). It will be hosted within the Faculty of Natural and Agricultural Sciences (NAS) alongside the other ARC-DALLRD-UFS research chairs, namely Climate Change and Agriculture, Innovative Agro-processing for Climate-smart Food System, Agriculture Risk Financing and Sustainable Livestock Production.

The aim of the new ARC-DALLRD-UFS research chair, explains Prof Labuschagne, who is also leading the National Research Foundation (NRF) SARChI Chair in Diseases and Quality of Field Crops, is to breed climate resilient crops with high levels of nutrients such as iron, zinc, provitamin A and essential amino acids, as well as disease resistance, in collaboration with the ARC.

Breeding of climate resilient crops

“We are all aware of the need for food security in South Africa. Climate change is already negatively impacting food production. With this research chair, in collaboration with the ARC, we hope to increase food security through crops that have intrinsic high nutritional value, for example, high levels of iron and zinc and provitamin A, of which there are high levels of deficiency in our population, and at the same time increase climate resilience (such as heat and drought tolerance) in these crops.

“We will be working on breeding climate-resilient, nutrient-rich and disease-resistant pigeon pea and cowpea cultivars; maize rich in provitamin A, iron and zinc; highly nutritious sweet and bitter sorghum; rust-resistant and good-quality wheat; high-yielding and nutritious indigenous vegetables such as amaranth and amadumbi; and research on potato, sweet potato and cassava for human and industrial uses,” says Prof Labuschagne.

The new chair will complement the research that is already being done for the SARChI chair, but with the ARC as partner. It will combine the expertise and resources of Plant Breeding at the UFS with that of the ARC-VIMP (Vegetable, Industrial and Medicinal Plants), ARC-GC (Grain Crops) and ARC-SC (Small Grains). The chair research will include orphan crops such as cowpea, pigeon pea and indigenous vegetables, as well as root and tuber crops such as potato and cassava, and cereals such as wheat, maize and sorghum.

Collaborative research

“The focus of this chair is on collaborative research and student training with the ARC, but the research area will still focus on the development of nutrient-rich and disease-resistant food-security crops. It will also have an additional focus of climate resilience, and the inclusion of orphan crops indigenous to Africa and South Africa.”

Prof Labuschagne says it is exciting that collaborative research can now be done with the unique expertise and resources (laboratory equipment, fields, greenhouses etc.) of several research institutes for the benefit of food and nutritional security in South Africa. Doing this research in a large team with lots of expertise in different areas will certainly yield more and better results with a larger impact on food security.

“This is a very exciting development in agricultural research now that we are part of a large team all working towards the same goal of improving food security, sharing expertise and resources and also doing collaborative training of MSc and PhD students who will become the scientists of tomorrow, taking this quest into the future.”

Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation, says this chair is aligned to the UFS Vision 130 strategy, shaped by excellence and impact, sustainability and society. “This distinguished chair led by Prof Labuschagne recognises exceptional achievement and pre-eminence in the field to catalyse and ignite new talent and new knowledge. It marks an exciting opportunity to deepen our understanding of breeding climate-resilient vegetables and grains aligned to our expertise in agriculture.”

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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