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01 April 2025 | Story Andre Damons | Photo Supplied
Health care
Those who took part in the community engagements are: From left Dr Kamo Mothibi from the UFS, Irene Mokgadi from CUT, Dr Mosebi Thejane (UFS), Ahlume Nkumbesi (UFS), Dr Lebogang Mogongoa (CUT), Minnie Mbokazi (UFS), Dr Happy Phage (CUT), Dr Phindile Shangase (UFS) and Teboho Mhlanga from the Free State Department of Health. Seated in from are Meshack Mothupi, driver from CUT, and Sipho Zulu (UFS).

The Division of Public Health at the University of the Free State (UFS) together with the Central University of Technology (CUT), and the Free State Department of Health’s Disability Unit, held community engagements recently by visiting rehabilitation services in Bloemfontein. 

These engagements were part of the co-funded project: Capacity building for the use of implementation science in various typologies in low- and middle-income countries for the prevention and/or management of the quadruple burden of disease. This was phase two in this project with the last phase including a symposium that is expected to take place on 1 April on the UFS Bloemfontein Campus.

Qhomane Mhlanga, a representative from the Free State Department of Health who is actively involved in this project, and her team, identified rehabilitation services for a case study. They also identified stakeholders to be visited during this community engagement in order to gather information on their engagement with Mangaung University of the Free State Community Partnership Programme (MUCPP). The team also visited stakeholders at the Phelang Disability Home, Carel du Toit Special School, and the Department of Education (Inclusive Education). 

 

Research to improve health care service

Dr Phindile Shangase from the Division of Public Health, and Principal Investigator at UFS, says the purpose of community visits was to engage service providers on the implementation strategies. This includes analysing alignment of implementation strategies with the policy (National Rehabilitation Policy 2000, Free State Rehabilitation Policy Guidelines, Framework and Strategy for Disability and Rehabilitation Service in South Africa 2015-2020) as well as identifying facilitators and barriers to implementation.

“It is the intention of the Division of Public Health, UFS to continue collaborations with stakeholders in implementation science research to improve health care service delivery and outcomes. The Division of Public Health also intends to add postgraduate research studies on implementation science in the near future.

“The visit to the clinic sought to establish the services provided by the rehabilitation unit, the referral system, and how the unit collaborates with external stakeholders to enhance the service. We gained knowledge of categories of healthcare professionals in rehabilitation services, e.g., occupational therapists, physiotherapists, speech and language therapists, audiologists, orthotists and prosthetists, rehabilitation doctors, optometrists, community rehabilitation workers. Some of these professionals are not available in the facilities visited,” says Dr Shangase. 

It was identified that, she continues, early hearing screening services for children are not available at healthcare facilities. Early hearing screening helps identify hearing defects which could be managed early to avoid complications that lead to hampered education and poor quality of life.


Outcome of engagements

Before the community outreach began, the UFS/CUT team, in collaboration with the Department of Health, convened to discuss strategies for navigating the Implementation Science project. The meeting focused on identifying key stakeholders and developing approaches essential for the project's success, drawing insights from the Department of Health's Mangaung Metro implementation science case study. 

The team identified five primary approaches for the project: Health, Education, Livelihood, Social, and Empowerment. Additionally, the discussion highlighted both the barriers and enablers related to each approach, which are crucial for ensuring effective project implementation and sustainable outcomes. Free State rehabilitation policy guidelines document was also applied to evaluate the case study.

According to Dr Shangase, the outreach will help with drafting of an intervention plan to address policy implementation gaps identified. The information gathered will assist in commissioning further research to improve health outcomes. “The intention is to collaborate with the Department of Health to work on past research outputs, presented during research day conferences, for implementation in healthcare facilities. Newly identified research areas will also prompt projects in healthcare facilities, led by the academic partners, UFS, Division of Public Health as well as the Department of Health Sciences, CUT.”

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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