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14 April 2025 | Story Martinette Brits | Photo Kaleidoscope Studios
Jeremiah Hlahla
Jeremiah Hlahla, 27, proudly graduates with a PhD in Botany.

At just 27 years old, Dr Jeremiah Hlahla has achieved a remarkable milestone: earning his PhD in Botany, conferred on Thursday 10 April. His journey is one of perseverance, academic curiosity, and the determination to rise above significant personal and financial challenges.  

 

Resilience rooted in early hardship 

Growing up in Nkomazi, Mpumalanga, Dr Hlahla’s early life was marked by profound loss. His mother passed away when he was still young, and in Grade 11, he lost his father. Left without the support of his immediate family, he was placed in an orphanage alongside his sister. Despite these immense challenges, Dr Hlahla remained focused on his education.  

“From Grade 10, I stayed behind at school to do my homework and study,” he recalls. “By Grade 12, I asked the pastor if I could use the church office to study. He allowed me, and throughout matric, I would go straight from school to the church office.” 

 

A passion for science and a decisive pivot 

Dr Hlahla’s fascination with science began in Grade 4 when he first encountered the topic of Matter and Materials. “It was a fascinating subject for me,” he says. By Grade 9, he had decided to become a scientist, though he was still unsure of the specific field. 

After matric, he negotiated with an Anglo-American bursary manager to study biology instead of electrical engineering. “I later applied for biochemistry and botany at the University of Johannesburg because I enjoyed biology - but over the years, I found plant science especially interesting.” 

The pivotal moment in his life came when he was awarded an Anglo-American scholarship. “That was a huge turning point in my life,” he says. “After matric, I didn’t know what I would do next. But after one psychometric exam and two rounds of interviews, I received the scholarship, and my life improved.” 

With renewed motivation, he continued his studies and pursued a Master's degree, despite having no financial resources at the time. “When I arrived at the University of the Free State (UFS), I had just left Pretoria with my bags and no money,” he recalls. His supervisor, Dr Makoena Moloi, recommended him for a National Research Foundation (NRF) grant to cover his expenses. He was later awarded a bursary from Carl Zeiss. 

“Dr Moloi wanted a hardworking person,” Dr Hlahla says. “She also helped me improve my academic writing.”

 

Perseverance through a pandemic 

The COVID-19 pandemic brought unexpected setbacks, derailing his MSc research. “After the lockdown, I returned to find my plants had died. I had to start from scratch,” he says. Despite this, he completed his experiments by August 2021 and submitted his MSc with distinction. 

“It is incredibly rewarding to see years of hard work culminate in a PhD,” he reflects. 

 

Looking ahead: Researching for a food-secure future 

Now a postdoctoral researcher in plant breeding, Dr Hlahla is working on developing drought-tolerant edamame cultivars – research inspired by his PhD work. 

 “What excites me the most is breeding drought-tolerant edamame cultivars based on my previous research,” he says. “I am also thrilled to be working with Prof Maryke Labuschagne and Prof Rouxlene van der Merwe.” 

Dr Hlahla’s journey has given him insight into what it takes to succeed against the odds. His message to students navigating hardship is clear: 

“Stay focused on your goals. How you respond to what happens to you will determine your future. Someone is always willing to help - so find support and use it. Hard work, willingness, and determination will take you far.”

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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