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15 April 2025 | Story Anthony Mthembu | Photo Supplied
Kay-leigh van Rooyen
Kay-Leigh van Rooyen, Research Assistant at the University of the Free State (UFS), was one of sixteen individuals selected to participate in the 2024 Abe Bailey Travel Bursary.

As one of only sixteen recipients of the prestigious 2024 Abe Bailey Travel Bursary, Kay-Leigh van Rooyen, Research Assistant at the University of the Free State (UFS), recently returned from a life-changing journey across the United Kingdom. Representing the UFS on this esteemed programme, van Rooyen joined a cohort of emerging South African leaders in a transformative cultural and academic exchange. 

Reflecting on the experience, she described it as “nothing short of amazing.” 

“The experience was so much more than just visiting new places,” she said. “It was about engaging in meaningful conversations, forming lasting relationships, and gaining fresh perspectives on global issues.”

The Abe Bailey Travel Bursary aims to empower young South Africans through leadership development, cross-cultural exchange, and exposure to international dialogue. According to van Rooyen, this initiative was a powerful platform for personal growth, enabling her to see the world – and South Africa - through new lens.

“I learned the power of perspective - how others view our country, and how to understand global challenges from diverse vantage points,” she said. “I also realised that leadership is not about titles, but about influence and empathy.” 

 

A journey through the UK 

The bursary cohort convened in Cape Town on 23 November 2023 before departing for the UK, where they travelled from London to Edinburgh and back. The programme officially concluded on 18 December 2024/3. 

During the tour, the group visited iconic institutions such as the Royal Observatory in Greenwich, the British Library, the Francis Crick Institute, and the Houses of Parliament. For van Rooyen, the highlight was the opportunity to engage with thought leaders and changemakers. 

“One of the most memorable moments was having lunch in a chamber of the House of Lords at the Palace of Westminster with Lord Karan Bilimoria, the founder and chairman of Cobra Beer. The conversation was insightful and inspiring,” she said.  

 

A global stage for the UFS

Van Rooyen emphasised the professional impact of the experience, noting how it shaped her perspective on the role of academia in society. 

“This experience has changed the way I approach my work. I’ve developed a deeper appreciation for the importance of bridging the gap between academia and industry - especially how we can make research more practical and impactful,” she explained. 

She also highlighted the broader benefit for the UFS community. 

“Global engagements like these position the UFS as part of the international conversation. Our students and staff have valuable insights to share,  and we can learn so much from other institutions.” 

Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS and Chair of the university’s Abe Bailey Travel Bursary selection committee, echoed these sentiments. 

“The Travel Bursary so elegantly aligns with the vision and heart of the UFS - namely, to expose our students to a wider world and its global connections,” he said. 

 

Inspiring the next generation of UFS leaders 

Encouraging fellow UFS staff and students to apply for the bursary, van Rooyen emphasised the personal and professional rewards. 

“It challenges you to think critically, engage meaningfully, and build relationships with people you wouldn’t ordinarily meet,” she said. 

Prof Reddy praised van Rooyen for her achievements and representation of the UFS on a global stage.  

“Her experiences and insights demonstrate that she is an exceptional ambassador – not only as an Abe Bailey alumnus, but also as a symbol of the excellence the UFS strives for. We are extremely proud of Kay-Leigh and wish her well as we look forward to the great things that lie ahead for her.”

 

 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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