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24 April 2025 | Story Martinette Brits | Photo Barend Nagel
Mainstream Final Project
Five postgraduate students from Ethiopia and Togo with Prof Corli Witthuhn, coordinator of the MAINSTREAM project, during their academic exchange visit to the University of the Free State. From the left: Prudence Bilabina, Ame Houngo, Prof Corli Witthuhn, Gemedo Shengu, Fanny Sibabi, and Debela Bedada.

The University of the Free State (UFS) has welcomed a cohort of international students as part of the Mobility 4 Agricultural International Networks Supporting Thematic Resilience and Enhancing Adaptation and Mitigation (MAINSTREAM) project, a significant European Union-funded initiative aimed at boosting agricultural education and research across the African continent.

A group of postgraduate students from Togo and Ethiopia have recently joined the University of the Free State as part of the MAINSTREAM project. “Two doctoral students from Togo – Ame Houngo and Fanny Sibabi – are based in the Department of Sustainable Food Systems and Development and will be supervised by Dr Alba du Toit and Prof Maryke Labuschagne,” says Prof Corli Witthuhn from the Department of Sustainable Food Systems and Development at the UFS, who serves as the coordinator of the MAINSTREAM project. Master’s student Prudence Bilabina, also from Togo, is hosted by the Department of Agricultural Economics under the supervision of Prof Henry Jordaan.

From Ethiopia, doctoral student Debela Bedada and master’s student Gemedo Shengu are both pursuing their research in the Department of Agricultural Economics, supervised by Prof Nicky Matthews and Dr Janus Henning respectively.

A Ugandan student will soon join them on 22 April for a three-month traineeship. “He is an undergraduate Agriculture student who will register for a service-learning module at the UFS and spend the three months working on a farm,” explains Prof Witthuhn. The student hails from the Mountains of the Moon University in Uganda.

By June 2025, the university anticipates the arrival of four more students from Uganda – three at master’s level and one traineeship participant – bringing the total number of MAINSTREAM students hosted by UFS this year to ten.

 

Building a climate-resilient future through agricultural education

The MAINSTREAM project aims to foster education and skills improvement in agricultural knowledge systems, with a strong focus on climate change resilience. According to Prof Witthuhn, the project “strives to influence the common agenda for addressing education and skills improvement … targeting transformations with the tertiary agricultural education community, policy, and industry actors”.

An important aspect of the initiative is its emphasis on inclusion, particularly regarding African women who remain underrepresented in higher education agricultural programmes. “Mobility schemes will also be used to break cross-African gendered perceptions of agriculture … and to further provide for a gender-sensitive learning environment and institutional culture,” Prof Witthuhn notes.

The UFS’ participation forms part of a larger network of partner institutions across Africa and Europe, including Arsi University (Ethiopia), the University of Kara (Togo), the Mountains of the Moon University (Uganda), Jaramogi Oginga Odinga University of Science and Technology (JOOUST, Kenya), the University of Sine Saloum El Hadji Ibrahima Niasse (USSEIN, Senegal), and the Weihenstephan-Triesdorf University of Applied Science (Germany).

 

Strengthening research, networks, and collaboration at the UFS

This four-year project, running from 2024 to 2027, will host two cohorts of students. “We are a partner in the project that will run over four years … one of the UFS master’s students, Rinus Behrens from the Department of Sustainable Food Systems and Development, is currently spending four months at JOOUST in Kenya as part of the programme,” adds Prof Witthuhn.

The presence of these students at the UFS marks a pivotal moment for both the institution and its international counterparts. “For the institution, it creates the opportunity for new networks, new research opportunities, internationalisation of our research endeavour, and increased research outputs,” she says.

During their stay, master’s and doctoral students will engage in academic research aligned with their fields of study, while traineeship students will gain hands-on agricultural experience on farms in the Bloemfontein area.

Bedada says the programme is already making a meaningful impact on his academic journey. “I am analysing the impact of agricultural mechanisation on food security and production. It is a big opportunity, because it gives me a chance to expand my knowledge and skills, and to develop my research work to international level.”

Similarly, Houngo says the experience so far has been enriching. “I have already learned a lot, and I hope to replicate the experience in my hometown,” he shares.

Behind the scenes, UFS staff and departments are instrumental in ensuring the programme’s success. “They provide host departments, academic leadership, and supervision to the six students,” says Prof Witthuhn, emphasising the collaborative effort required to support this international initiative.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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