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Prof Elizabeth Erasmus
Prof Elizabeth Erasmus during her inaugural lecture, Molecules of Change: Chemistry for a Better Tomorrow, on 20 August, highlighting how innovative chemistry can turn waste into value and promote sustainable solutions.

With climate change, resource scarcity, and environmental pollution among the most pressing challenges of our time, Prof Elizabeth (Lizette) Erasmus used her inaugural lecture on Wednesday, 20 August to show how chemistry can provide powerful, practical answers. In her lecture, Molecules of Change: Chemistry for a Better Tomorrow, she traced her journey from fundamental research to pioneering innovations that turn waste into value, protect ecosystems, and improve food security.

During her talk, Prof Erasmus – Researcher in the Department of Chemistry – recalled a moment in 2018 that reshaped her career trajectory. While preparing a Sasol research grant on copper oxide nanoparticles, an entrepreneur assisting with the proposal posed a deceptively simple challenge: “So what?” “Although upsetting at first, those two words completely reshaped my outlook,” she explained. “They inspired my journey from purely academic chemistry towards more applied, impactful research – with the mission of not only advancing science, but of also improving society and the environment.”

 

From fundamental science to global solutions

Prof Erasmus began her career in organometallic chemistry, preparing and characterising complex molecules to understand their reactivity and physical properties. Later, her focus shifted to heterogeneous catalysis, where she explored nanomaterials and surface chemistry.

Her research has since evolved towards developing sustainable technologies that address urgent global challenges. One example is agricultural innovation: using green solvents to extract cellulose from wattle tree bark to create biodegradable superabsorbent polymers. “Unlike the polyacrylates in baby diapers, these SAPs degrade into nutrients for soil microbes and plants,” she explained. “By loading them with fertiliser, we develop slow-release, water-retaining materials that improve agricultural sustainability.”

Other projects include producing biochar to restore degraded soils, creating natural growth enhancers such as wood vinegar, and designing an ‘ultimate fertiliser’ that combines these products for long-term soil health. Her group also works on environmental remediation, developing hydrophobic sponges to absorb oil spills, repurposing building waste to clean polluted water, and using innovative chemistry to convert carbon dioxide into valuable products.

“We are even looking at one of the fastest-growing waste streams: e-waste,” Prof Erasmus noted. “With more gold per ton than natural ore, e-waste represents both a challenge and an opportunity. By developing porous absorbent materials, we can selectively capture and reduce gold ions directly to metallic gold – recovering a precious resource from waste.”

She concluded by crediting her team and collaborators: “This, however, is only the tip of the iceberg. The bulk of the work lies beneath the surface, carried out by dedicated students, collaborators, mentors, colleagues, friends, and family. I owe them my deepest gratitude, for they are the ones who truly sustain this journey of transforming chemistry into solutions for a better world.”

 

About Prof Erasmus

Prof Elizabeth (Lizette) Erasmus obtained all her degrees at the University of the Free State: a BSc (2001), BSc Honours in Chemistry (2002), MSc in Chemistry (2003), and a PhD in Chemistry (2005). She has published more than 80 research papers, holds an H-index of 21, and has extensive experience in supervising MSc and PhD students.

After serving as a senior researcher at the CSIR, she returned to academia at the UFS, where her international collaborations in the Netherlands and at UC Davis broadened her focus from organometallic chemistry to heterogeneous catalysis and nanochemistry. Her expertise spans organometallic chemistry, electrochemistry, surface characterisation, and nanomaterials.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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