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Prof Hester Klopper
Prof Hester Klopper, newly appointed Vice-Chancellor and Principal of the University of the Free State.

Re-discovering Our Institutional Heart was the theme of the official opening address of the University of the Free State (UFS) presented by newly appointed UFS Vice-Chancellor and Principal, Prof Hester Klopper, as she addressed UFS staff members in the Odeion Auditorium on the Bloemfontein Campus.

Prof Klopper sketched the current global, national, and local contexts that have affected higher education in general, and the UFS in particular, giving an overview of where the institution has come from, where it currently is, and where it is going. She emphasised the need to focus on the qualities and research areas for which the university has become well known, and to stay true to the values and principles set out in its Vision 130.

“Vision 130 illuminates our way into the future – expounding how we want to establish ourselves as a top-tier university that is continually extending its influence and impact locally, regionally, and globally,” she said.

 

The institutional heart

Prof Klopper referred to the image of a heart that is reflected in the UFS marketing logo, encouraging staff to rediscover what lies at the heart of the institution, and what sets it apart.

“A university such as ours inevitably forms and moulds the lives and characters of the people associated with it; and in turn, it too is shaped and transformed by those who have graced its campuses over the decades. It too has a character. And it certainly has a heart.”

She elaborated on the metaphorical meanings locked up within the concept of a heart, touching on how it symbolised vitality, flow, and energy, interconnectedness, and a sense of belonging. She also highlighted its significance as a beacon of resilience.

“It is associated with courage and steadfastness. Over the past 120 years, the University of the Free State has prevailed despite adversity and has managed to constantly reinvent itself in order to remain relevant, without losing sight of the values in which it is anchored,” she said.

 

Priorities for tenure

One of the broad focus areas that Prof Klopper identified as a priority during her term was establishing the UFS as an innovation and entrepreneurial ecosystem. “This includes advancing transdisciplinary research, moving towards identifying two to three core research themes that address local, regional, and global challenges, and strengthening our unique offering,” she said.

Another focus area will be working towards systemic sustainability, which will include a disciplined approach towards financial management, as well as revision and optimisation of the academic model. She also indicated that internationalisation will be a core theme during her tenure, as will the establishment of the UFS as a first-choice employer and a magnet for talent. To this end, she announced the establishment of a VC Strategic Personnel Fund to grow and attract the best academic talent.

 

Innovation through connection

Prof Klopper concluded that the heartbeat of the UFS lies in innovation through connection.

For her, innovation is expressed in the university’s cutting-edge programme content, its focus on creating a culture of entrepreneurship, optimisation of the academic model, and finding new ways to diversify income streams. On the other hand, connection is reflected in heightened internationalisation, expansive collaborative networks, and a renewed focus on transdisciplinary research and real societal impact through engaged scholarship.

“My sincere wish is that each one of you will rediscover this heartbeat and that it will inspire you this year to take our great institution to even greater heights,” she said.

 

Click to view document Click here for the official opening speech.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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