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17 February 2025 | Story Andre Damons | Photo Supplied
Prof Carolina Pohl-Albertyn
Prof Carlien Pohl-Albertyn is the NRF SARChI Research Chair in Pathogenic Yeasts at the UFS.

A new study by researchers from the University of the Free State (UFS), the National Health Laboratory Service, and the University of Venda has confirmed for the first time that common brown locusts are carriers of pathogenic yeasts that can cause severe infections in humans – especially in people with compromised immune systems or who are seriously ill.

The study, ‘South African brown locusts, Locustana pardalina, hosts fluconazole resistant, Candidozyma (Candida) auris (Clade III)’, highlights for the first time the presence of the pathogenic (disease-producing) fungal yeast C. auris in the digestive tract of the locusts, and shows their potential in disseminating this emerging pathogen. The research started in April 2022, when 20 gregarious (swarming) adult locusts were collected during a large locust outbreak which occurred from September 2021 to May 2022 in the semi-arid Eastern Karoo region in the Eastern Cape. The study is still under peer review.

According to Prof Carlien Pohl-Albertyn, National Research Foundation (NRF) SARChI Research Chair in Pathogenic Yeasts, three C. auris strains were isolated from three different adult locusts, two of which also harboured strains of another potentially pathogenic yeast, Candida orthopsilosis. “The fact that we were able to isolate C. auris from 15% of the sampled locusts, using non-selective media and a non-restrictive temperature of 30°C, may indicate that C. auris is abundant in the locusts and that specific selective isolation is not mandatory,” Prof Pohl-Albertyn said.

“Interestingly, C. auris was isolated from the fore- and hindgut of the locusts. Isolation from the foregut, which is dedicated to food intake and storage, filtering and partial digestion, indicates that C. auris was probably obtained by the locusts via feeding activities. Isolation from the hindgut confirms that C. auris can survive the digestive processes in the midgut and is likely to be released back into the environment via faeces.”

Healthy humans are not at great risk

One of the C. auris strains was studied in more detail. This strain was not resistant to disinfectants but showed decreased susceptibility to the common antifungal drug fluconazole. This is a characteristic of this yeast species and thus not surprising. Most of the emerging pathogenic yeasts show this intrinsic resistance. This highlights the urgent need to discover and develop new antifungal drugs.

Prof Pohl-Albertyn, also a Professor of Microbiology in the UFS Department of Microbiology and Biochemistry, says, “Healthy humans are not at great risk for infection by this yeast and there is currently no proof that ingestion may be harmful to them. This is unfortunately not the case for people with compromised immune systems or who are seriously ill. However, few susceptible people come into direct contact with the locusts in South Africa.”

She added that there are treatment options available, using other antifungal drugs, but C. auris can become resistant to all the currently available antifungal drugs.

Importance of the study

“The fact that locusts are a food source for other animals, such as birds, could lead to eventual distribution of the yeast to people. In other countries, wild locusts are a food source for humans and there more direct transmission may be possible,” Prof Pohl-Albertyn said.

She explained that this study tries to answer questions regarding the natural hosts of this emerging pathogen and how it may facilitate the spread of the pathogen to the rest of the environment. The study is one part of the puzzle regarding how new pathogens may emerge from the environment and spread to people.

“One of the questions in the field of pathogenic yeasts is how C. auris was able to emerge as a pathogen in several different countries in a relatively short period. It is well known as a hospital-acquired pathogen, but it is not known where in the environment it occurs naturally, and which environmental factors may have shaped its evolution and ability to cause human infections. This has implications for the prevention of the spread of this specific yeast species, as well as our preparedness for new pathogenic yeasts that may be emerging from the environment.”

News Archive

Construction at Qwaqwa Campus creates jobs for local community
2010-05-28

At the construction site hand-over ceremony are, from the left: Dr
Elias Malete, Dr Dipane Hlalele, Prof. WF van Zyl and Mr Derek Canavan
(Freelance Construction)
Photo: Thabo Kessah


Local labour is set to benefit from at least 20 job opportunities that will be created during the building of new facilities valued at R13,5 million for the Faculty of Education on the Qwaqwa Campus of the University of the Free State (UFS).

This was announced by Mr Derek Canavan, an architect from Freelance Construction, during the sod-turning ceremony held on the construction site recently.

The soon to be built facilities will include a 100-seater lecture hall, two 50-seater classrooms, an office block, ablution facilities, two separate laboratories for biology and science, as well as an IT laboratory with 70 work stations. All these facilities will be user-friendly to the disabled students.

Addressing a contingent of brains behind the project that included Mr Nico Janse van Rensburg, Manager of Physical Planning at the UFS, Dr Elias Malete, the Qwaqwa Campus Principal, said that this addition to the existing infrastructure would enable the campus to meet its enrolment and output challenges.

“These new facilities will no doubt increase the university’s academic and research capacity and will certainly help us respond positively to Minister Blade Nzimande’s call to institutions of higher learning to improve on scientific research. We are therefore pleased with this multi-million rand investment from the National Department of Education and the UFS,” he concluded.

Also attending was Dr Dipane Hlalele, Programme Head in the faculty, who was also pleased with the new facilities. “These facilities will help us to answer to our community’s needs of pre-school and foundation-phase teacher training which will be added to our study programme in January 2011. We will be introducing a new B.Ed. degree in Pre-school and Foundation phases and these facilities will help in the production of quality teachers for the benefit of our community,” he said.

The new building is expected to be ready for usage in June 2011.

Media Release
Issued by: Lacea Loader
Director: Strategic Communication (acting)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl@ufs.ac.za  
27 May 2010
 

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