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17 February 2025 | Story Andre Damons | Photo Supplied
Prof Carolina Pohl-Albertyn
Prof Carlien Pohl-Albertyn is the NRF SARChI Research Chair in Pathogenic Yeasts at the UFS.

A new study by researchers from the University of the Free State (UFS), the National Health Laboratory Service, and the University of Venda has confirmed for the first time that common brown locusts are carriers of pathogenic yeasts that can cause severe infections in humans – especially in people with compromised immune systems or who are seriously ill.

The study, ‘South African brown locusts, Locustana pardalina, hosts fluconazole resistant, Candidozyma (Candida) auris (Clade III)’, highlights for the first time the presence of the pathogenic (disease-producing) fungal yeast C. auris in the digestive tract of the locusts, and shows their potential in disseminating this emerging pathogen. The research started in April 2022, when 20 gregarious (swarming) adult locusts were collected during a large locust outbreak which occurred from September 2021 to May 2022 in the semi-arid Eastern Karoo region in the Eastern Cape. The study is still under peer review.

According to Prof Carlien Pohl-Albertyn, National Research Foundation (NRF) SARChI Research Chair in Pathogenic Yeasts, three C. auris strains were isolated from three different adult locusts, two of which also harboured strains of another potentially pathogenic yeast, Candida orthopsilosis. “The fact that we were able to isolate C. auris from 15% of the sampled locusts, using non-selective media and a non-restrictive temperature of 30°C, may indicate that C. auris is abundant in the locusts and that specific selective isolation is not mandatory,” Prof Pohl-Albertyn said.

“Interestingly, C. auris was isolated from the fore- and hindgut of the locusts. Isolation from the foregut, which is dedicated to food intake and storage, filtering and partial digestion, indicates that C. auris was probably obtained by the locusts via feeding activities. Isolation from the hindgut confirms that C. auris can survive the digestive processes in the midgut and is likely to be released back into the environment via faeces.”

Healthy humans are not at great risk

One of the C. auris strains was studied in more detail. This strain was not resistant to disinfectants but showed decreased susceptibility to the common antifungal drug fluconazole. This is a characteristic of this yeast species and thus not surprising. Most of the emerging pathogenic yeasts show this intrinsic resistance. This highlights the urgent need to discover and develop new antifungal drugs.

Prof Pohl-Albertyn, also a Professor of Microbiology in the UFS Department of Microbiology and Biochemistry, says, “Healthy humans are not at great risk for infection by this yeast and there is currently no proof that ingestion may be harmful to them. This is unfortunately not the case for people with compromised immune systems or who are seriously ill. However, few susceptible people come into direct contact with the locusts in South Africa.”

She added that there are treatment options available, using other antifungal drugs, but C. auris can become resistant to all the currently available antifungal drugs.

Importance of the study

“The fact that locusts are a food source for other animals, such as birds, could lead to eventual distribution of the yeast to people. In other countries, wild locusts are a food source for humans and there more direct transmission may be possible,” Prof Pohl-Albertyn said.

She explained that this study tries to answer questions regarding the natural hosts of this emerging pathogen and how it may facilitate the spread of the pathogen to the rest of the environment. The study is one part of the puzzle regarding how new pathogens may emerge from the environment and spread to people.

“One of the questions in the field of pathogenic yeasts is how C. auris was able to emerge as a pathogen in several different countries in a relatively short period. It is well known as a hospital-acquired pathogen, but it is not known where in the environment it occurs naturally, and which environmental factors may have shaped its evolution and ability to cause human infections. This has implications for the prevention of the spread of this specific yeast species, as well as our preparedness for new pathogenic yeasts that may be emerging from the environment.”

News Archive

Graduation ceremony awaited with great excitement
2011-06-22

Everything is running according to plan on the Bloemfontein Campus of our university for the graduation ceremony of Ms Oprah Winfrey, which is taking place in the Callie Human Centre today, 24 June 2011. 

The graduation ceremony, during which an Honorary Doctorate in Education will be conferred upon Ms Winfrey, promises to be something special. Measured against the smooth course of the preparations, the speed at which the tickets were obtained and the continuous interest amongst UFS staff and students, as well as members of the public, this promises to be a real 2011 highlight for all who are going to attend the event. 

Strict safety and security measures shall be enforced and therefore, ticket holders are requested to make sure that they arrive early on the Bloemfontein Campus. 

The UFS is aware of the fact that tickets are sold illegally at shopping centres in Bloemfontein. Computicket equipment shall be used on the premises tomorrow to ensure that only persons who have original tickets in their possession are admitted. People found to be in possession of forged tickets tomorrow shall be prosecuted. 

The doors of the Callie Human Centre shall open at 13:00 on Friday for ticket holders and shall be closed strictly at 14:00. For safety and security reasons, nobody shall be allowed to enter or leave the building after the doors were closed. 

Although the entrance gates to the Bloemfontein Campus shall not be closed, certain streets on the campus will be closed for some time today (23 June 2011) and the whole of Friday (24 June 2011). More information about this is available at www.ufs.ac.za 

Clear signs, as well as voluntary staff, shall guide parking visitors to their parking spaces. The volunteers were selected after staff of all three campuses offered their assistance for the day. 

Amongst the 4 500 guests attending the graduation ceremony are various well-known personalities and dignitaries, alumni, learners and other stakeholders of the university. Good reaction has also been received from the local, national and international media. 

The programme in the Callie Human Centre is as follows: 

13:00 Doors open
14:00 Doors close
14:30 Opening performances
15:30 Graduation ceremony
16:00 Ms. Winfrey’s speech and question and answer session with students
18:00 Programme ends.
 

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