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17 February 2025 | Story Andre Damons | Photo Supplied
Prof Carolina Pohl-Albertyn
Prof Carlien Pohl-Albertyn is the NRF SARChI Research Chair in Pathogenic Yeasts at the UFS.

A new study by researchers from the University of the Free State (UFS), the National Health Laboratory Service, and the University of Venda has confirmed for the first time that common brown locusts are carriers of pathogenic yeasts that can cause severe infections in humans – especially in people with compromised immune systems or who are seriously ill.

The study, ‘South African brown locusts, Locustana pardalina, hosts fluconazole resistant, Candidozyma (Candida) auris (Clade III)’, highlights for the first time the presence of the pathogenic (disease-producing) fungal yeast C. auris in the digestive tract of the locusts, and shows their potential in disseminating this emerging pathogen. The research started in April 2022, when 20 gregarious (swarming) adult locusts were collected during a large locust outbreak which occurred from September 2021 to May 2022 in the semi-arid Eastern Karoo region in the Eastern Cape. The study is still under peer review.

According to Prof Carlien Pohl-Albertyn, National Research Foundation (NRF) SARChI Research Chair in Pathogenic Yeasts, three C. auris strains were isolated from three different adult locusts, two of which also harboured strains of another potentially pathogenic yeast, Candida orthopsilosis. “The fact that we were able to isolate C. auris from 15% of the sampled locusts, using non-selective media and a non-restrictive temperature of 30°C, may indicate that C. auris is abundant in the locusts and that specific selective isolation is not mandatory,” Prof Pohl-Albertyn said.

“Interestingly, C. auris was isolated from the fore- and hindgut of the locusts. Isolation from the foregut, which is dedicated to food intake and storage, filtering and partial digestion, indicates that C. auris was probably obtained by the locusts via feeding activities. Isolation from the hindgut confirms that C. auris can survive the digestive processes in the midgut and is likely to be released back into the environment via faeces.”

Healthy humans are not at great risk

One of the C. auris strains was studied in more detail. This strain was not resistant to disinfectants but showed decreased susceptibility to the common antifungal drug fluconazole. This is a characteristic of this yeast species and thus not surprising. Most of the emerging pathogenic yeasts show this intrinsic resistance. This highlights the urgent need to discover and develop new antifungal drugs.

Prof Pohl-Albertyn, also a Professor of Microbiology in the UFS Department of Microbiology and Biochemistry, says, “Healthy humans are not at great risk for infection by this yeast and there is currently no proof that ingestion may be harmful to them. This is unfortunately not the case for people with compromised immune systems or who are seriously ill. However, few susceptible people come into direct contact with the locusts in South Africa.”

She added that there are treatment options available, using other antifungal drugs, but C. auris can become resistant to all the currently available antifungal drugs.

Importance of the study

“The fact that locusts are a food source for other animals, such as birds, could lead to eventual distribution of the yeast to people. In other countries, wild locusts are a food source for humans and there more direct transmission may be possible,” Prof Pohl-Albertyn said.

She explained that this study tries to answer questions regarding the natural hosts of this emerging pathogen and how it may facilitate the spread of the pathogen to the rest of the environment. The study is one part of the puzzle regarding how new pathogens may emerge from the environment and spread to people.

“One of the questions in the field of pathogenic yeasts is how C. auris was able to emerge as a pathogen in several different countries in a relatively short period. It is well known as a hospital-acquired pathogen, but it is not known where in the environment it occurs naturally, and which environmental factors may have shaped its evolution and ability to cause human infections. This has implications for the prevention of the spread of this specific yeast species, as well as our preparedness for new pathogenic yeasts that may be emerging from the environment.”

News Archive

Kovsies proud of a gold PRISM Award for safety campaign
2015-05-05

Stefan Lotter, Leonie Bolleurs and Lacea Loader. All three are from the Departement of Communication and Brand Management at the UFS.
Photo: Hannes Pieterse

The University of the Free State, takes pride in the gold PRISM Award (from the Public Relations Institute of Southern Africa) for the B Safe Take Action safety campaign that has been rolled out on the campus since 2013 by the Department of Communication and Brand Management.

The campaign earned the Von H Brand Provocateur gold award in the internal communication category.

“The UFS is the only tertiary institution to receive a gold award. The award is a great honour for the department, considering the cream of South African public relations took part in the competition, and the standard was naturally very high. It was also a feather in the cap for us that the uniqueness of the campaign received national recognition from our peers in this manner, said Ms Lacea Loader, Director: Communication and Brand Management at the UFS.

The university is responsible for about 32 000 students and 4 000 members of staff on its three campuses: the Bloemfontein and South Campuses in Bloemfontein and the Qwaqwa Campus in the Eastern Free State. It is of cardinal importance for the university that its students, staff, and assets are safe.

Apart from safety measures that have been implemented by the UFS Protection Services, the B Safe Take Action campaign has also been rolled out on the three campuses of the UFS. The campaign supports the safety strategy of the university. It is aimed at developing a culture of safety awareness in students and staff alike. The purpose of the campaign is for staff and students to take ownership of their own safety. In addition, it creates awareness of the safety measures that are in place at the UFS.

The campaign has been rolled out on various communication platforms. These include placards, pamphlets, lamp-post advertisements, an advertisement board, emails, and messages on student communication portals such as Blackboard, the UFS web and intranet, social media, information boards in the campus parking areas and on the pedestrian walkways as well as messages on refuse bins around the campus. “The fact that a variety of communication platforms has been deployed, the striking design and character of the messages, and the number of target audiences that have been reached further contributed to the success of the campaign,” said Ms Loader,

The campaign also received a merit award from the International Association for Business Communication (IABC). The award will be presented on 15 June 2015 in San Francisco, USA.

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