Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
17 February 2025 | Story Andre Damons | Photo Supplied
Prof Carolina Pohl-Albertyn
Prof Carlien Pohl-Albertyn is the NRF SARChI Research Chair in Pathogenic Yeasts at the UFS.

A new study by researchers from the University of the Free State (UFS), the National Health Laboratory Service, and the University of Venda has confirmed for the first time that common brown locusts are carriers of pathogenic yeasts that can cause severe infections in humans – especially in people with compromised immune systems or who are seriously ill.

The study, ‘South African brown locusts, Locustana pardalina, hosts fluconazole resistant, Candidozyma (Candida) auris (Clade III)’, highlights for the first time the presence of the pathogenic (disease-producing) fungal yeast C. auris in the digestive tract of the locusts, and shows their potential in disseminating this emerging pathogen. The research started in April 2022, when 20 gregarious (swarming) adult locusts were collected during a large locust outbreak which occurred from September 2021 to May 2022 in the semi-arid Eastern Karoo region in the Eastern Cape. The study is still under peer review.

According to Prof Carlien Pohl-Albertyn, National Research Foundation (NRF) SARChI Research Chair in Pathogenic Yeasts, three C. auris strains were isolated from three different adult locusts, two of which also harboured strains of another potentially pathogenic yeast, Candida orthopsilosis. “The fact that we were able to isolate C. auris from 15% of the sampled locusts, using non-selective media and a non-restrictive temperature of 30°C, may indicate that C. auris is abundant in the locusts and that specific selective isolation is not mandatory,” Prof Pohl-Albertyn said.

“Interestingly, C. auris was isolated from the fore- and hindgut of the locusts. Isolation from the foregut, which is dedicated to food intake and storage, filtering and partial digestion, indicates that C. auris was probably obtained by the locusts via feeding activities. Isolation from the hindgut confirms that C. auris can survive the digestive processes in the midgut and is likely to be released back into the environment via faeces.”

Healthy humans are not at great risk

One of the C. auris strains was studied in more detail. This strain was not resistant to disinfectants but showed decreased susceptibility to the common antifungal drug fluconazole. This is a characteristic of this yeast species and thus not surprising. Most of the emerging pathogenic yeasts show this intrinsic resistance. This highlights the urgent need to discover and develop new antifungal drugs.

Prof Pohl-Albertyn, also a Professor of Microbiology in the UFS Department of Microbiology and Biochemistry, says, “Healthy humans are not at great risk for infection by this yeast and there is currently no proof that ingestion may be harmful to them. This is unfortunately not the case for people with compromised immune systems or who are seriously ill. However, few susceptible people come into direct contact with the locusts in South Africa.”

She added that there are treatment options available, using other antifungal drugs, but C. auris can become resistant to all the currently available antifungal drugs.

Importance of the study

“The fact that locusts are a food source for other animals, such as birds, could lead to eventual distribution of the yeast to people. In other countries, wild locusts are a food source for humans and there more direct transmission may be possible,” Prof Pohl-Albertyn said.

She explained that this study tries to answer questions regarding the natural hosts of this emerging pathogen and how it may facilitate the spread of the pathogen to the rest of the environment. The study is one part of the puzzle regarding how new pathogens may emerge from the environment and spread to people.

“One of the questions in the field of pathogenic yeasts is how C. auris was able to emerge as a pathogen in several different countries in a relatively short period. It is well known as a hospital-acquired pathogen, but it is not known where in the environment it occurs naturally, and which environmental factors may have shaped its evolution and ability to cause human infections. This has implications for the prevention of the spread of this specific yeast species, as well as our preparedness for new pathogenic yeasts that may be emerging from the environment.”

News Archive

A time to celebrate: Autumn graduations
2016-04-07

General graduation information 
Livestreaming

The first series of graduations for the year are upon us. Graduates from all seven faculties, the Business School, and the School of Open Learning at the University of the Free State (UFS) will be celebrating their academic achievements. A total of 3681 qualifications will be conferred at ceremonies on the Bloemfontein Campus from 12 to 15 April 2016.

Sejakhumo Makhetha, daughter of our Vice-Rector: Student Affairs and External Relations, Dr Choice Makhetha, will be among the graduates receiving BA Governance and Political Transformation degrees. Coincidently, Dr Makhetha obtained her PhD in Political Science in 2003 at the UFS. Sejakhumo Makhetha is currently busy with her postgraduate diploma in the same field.

The four-day celebration symbolises the UFS prerogative as an institution to transform lives by producing leaders of tomorrow. Dr Muavia Gallie, Dr Sello Hatang, Dawie Roodt, and Nikiwe Bikitsha are expected to address these future leaders and guests at these ceremonies.

Addressed by the best

On the guest speaker line-up, we have Dr Gallie, a School and District Turnaround Strategist and education activist, who has been identified as one of the 10 Most Impressive Public Leaders for 2015 by the UFS Vice-Chancellor and Rector, Prof Jonathan Jansen. The former Head of Operations, Human Resources and Information and Communication Technology at the South African Council for Educators (SACE) has had more than 30 years of experience in education.

Dr Gallie and Dr Hatang will address graduates of the Faculties of Education, Health Sciences, Law, and Theology on 12 April 2016. Dr Hatang is the Chief Executive of the Nelson Mandela Foundation. In addition to being a founding member of the Advisory Council of the Council for the Advancement of the South African Constitution, Hatang has had the privilege of serving as the Head of Information Communications, and spokesperson for the South African Human Rights Commission as well as Director: South African History Archive at Wits University.

Dawie Roodt, founder, director, and chief economist of the Efficient Group, will speak at the Faculty of Economic and Management Science ceremony on 14 April 2016. This nationally-renowned economist boasts 30 years of experience in monetary and fiscal policy, and is one of the most referenced authors. In 2013, he published Tax, Lies and Red Tape.

As one of South Africa’s leading journalists, Nikiwe Bikitsha will draw on her 20-year career in radio, television, and journalism to address the Faculty of the Humanities graduates on the final day of graduations. Through her passion for Africa’s economic development and women empowerment, the co-founder and CEO of Amargi Media has been a successful Programme Director for UN, IMF and AU-related events.

 

Details of event

Dates: 12, 13, 14, 15 April 2016

Times: 09:00 and 14:30

Venue: Callie Human Centre, Bloemfontein Campus, University of the Free State

 

 

 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept