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New study finds emerging pathogen inside brown locusts

17 February 2025 | Story Andre Damons | Photo Supplied

Prof Carolina Pohl-Albertyn — Prof Carlien Pohl-Albertyn is the NRF SARChI Research Chair in Pathogenic Yeasts at the UFS.

A new study by researchers from the University of the Free State (UFS), the National Health Laboratory Service, and the University of Venda has confirmed for the first time that common brown locusts are carriers of pathogenic yeasts that can cause severe infections in humans – especially in people with compromised immune systems or who are seriously ill.

The study, ‘South African brown locusts, Locustana pardalina, hosts fluconazole resistant, Candidozyma (Candida) auris (Clade III)’, highlights for the first time the presence of the pathogenic (disease-producing) fungal yeast C. auris in the digestive tract of the locusts, and shows their potential in disseminating this emerging pathogen. The research started in April 2022, when 20 gregarious (swarming) adult locusts were collected during a large locust outbreak which occurred from September 2021 to May 2022 in the semi-arid Eastern Karoo region in the Eastern Cape. The study is still under peer review.

According to Prof Carlien Pohl-Albertyn, National Research Foundation (NRF) SARChI Research Chair in Pathogenic Yeasts, three C. auris strains were isolated from three different adult locusts, two of which also harboured strains of another potentially pathogenic yeast, Candida orthopsilosis. “The fact that we were able to isolate C. auris from 15% of the sampled locusts, using non-selective media and a non-restrictive temperature of 30°C, may indicate that C. auris is abundant in the locusts and that specific selective isolation is not mandatory,” Prof Pohl-Albertyn said.

“Interestingly, C. auris was isolated from the fore- and hindgut of the locusts. Isolation from the foregut, which is dedicated to food intake and storage, filtering and partial digestion, indicates that C. auris was probably obtained by the locusts via feeding activities. Isolation from the hindgut confirms that C. auris can survive the digestive processes in the midgut and is likely to be released back into the environment via faeces.”

Healthy humans are not at great risk

One of the C. auris strains was studied in more detail. This strain was not resistant to disinfectants but showed decreased susceptibility to the common antifungal drug fluconazole. This is a characteristic of this yeast species and thus not surprising. Most of the emerging pathogenic yeasts show this intrinsic resistance. This highlights the urgent need to discover and develop new antifungal drugs.

Prof Pohl-Albertyn, also a Professor of Microbiology in the UFS Department of Microbiology and Biochemistry, says, “Healthy humans are not at great risk for infection by this yeast and there is currently no proof that ingestion may be harmful to them. This is unfortunately not the case for people with compromised immune systems or who are seriously ill. However, few susceptible people come into direct contact with the locusts in South Africa.”

She added that there are treatment options available, using other antifungal drugs, but C. auris can become resistant to all the currently available antifungal drugs.

Importance of the study

“The fact that locusts are a food source for other animals, such as birds, could lead to eventual distribution of the yeast to people. In other countries, wild locusts are a food source for humans and there more direct transmission may be possible,” Prof Pohl-Albertyn said.

She explained that this study tries to answer questions regarding the natural hosts of this emerging pathogen and how it may facilitate the spread of the pathogen to the rest of the environment. The study is one part of the puzzle regarding how new pathogens may emerge from the environment and spread to people.

“One of the questions in the field of pathogenic yeasts is how C. auris was able to emerge as a pathogen in several different countries in a relatively short period. It is well known as a hospital-acquired pathogen, but it is not known where in the environment it occurs naturally, and which environmental factors may have shaped its evolution and ability to cause human infections. This has implications for the prevention of the spread of this specific yeast species, as well as our preparedness for new pathogenic yeasts that may be emerging from the environment.”

News Archive

Students receive hands-on crime scene investigation training

2016-09-02

Description: Crime scene investigation training Tags: Crime scene investigation training

Ntau Mafisa, a forensic science honours student
at the UFS, and Captain Samuel Sethunya from
the SAPS Crime Scene Management in
Bloemfontein.
Photo: Leonie Bolleurs

With murder and robbery rates on the rise, the Forensic Science Programme of the Department of Genetics at the University of the Free State is playing a key role in training South Africa’s future crime scene investigators and forensic laboratory analysts.

According to the Institute for Security Studies (ISS), murder and aggravated robbery rates for 2014/2015, as recorded by the South African Police Services (SAPS) have increased. Incidents of murder increased by 4.6% in the period from 2013/2014 to 2014/2015 and aggravated robbery increased by 8.5 % in the same period. The ISS is an African organisation thant enhances human security by providing independent and authoritative research, expert policy advice and capacity building.

Dr Ellen Mwenesongole, a forensic science lecturer at the Department of Genetics, said the university was one of a few universities in South Africa that actually had a forensic science programme, especially starting from undergraduate level.

Crime scene evaluation component incorporated in curriculum
As part of its Forensic Science Honours Programme, the department has, for the first time, incorporated a mock crime scene evaluation component in its curriculum. Students process a mock crime scene and are assessed based on how closely they follow standard operating procedures related to crime scenes and subsequent laboratory analysis of items of possible evidential value.

The mock crime scene forms part of a research project data collection of the honours students. In these projects students utilise different analytical methods to analyse and distinguish between different types of evidence such as hair fibres, cigarette butts, illicit drugs and dyes extracted from questioned documents and lipsticks.

Students utilise different analytical methods to analyse
and distinguish between different types of evidence.

This year, the department trained the first group of nine students in the Forensic Science Honours Programme. Dr Mwenesongole, who received her training in the UK at the University of Strathclyde in Glasgow, Scotland, and Anglia Ruskin University in Cambridge, England, said incorporating a crime scene evaluation component into the curriculum was a global trend at universities that were offering forensic science programmes.

Department of Genetics and SAPS collaborate
It is important to add this component to the student’s curriculum. In this way the university is equipping students not only with theoretical knowledge but practical knowledge on the importance of following proper protocol when collecting evidence at crime scenes and analysing it in the laboratory to reduce the risk of it becoming inadmissible in a court of law.

The Genetics Department has a good working relationship with the Forensic Science Laboratory and Free State Crime Scene Management of the Division Forensic Services of the SAPS. The mock crime scene was set up and assessed in collaboration with the Crime Scene Management Division of the SAPS. Although the SAPS provides specialist advanced training to its staff members, the university hopes to improve employability for students through such programmes.

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