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17 February 2025 | Story Andre Damons | Photo Supplied
Prof Carolina Pohl-Albertyn
Prof Carlien Pohl-Albertyn is the NRF SARChI Research Chair in Pathogenic Yeasts at the UFS.

A new study by researchers from the University of the Free State (UFS), the National Health Laboratory Service, and the University of Venda has confirmed for the first time that common brown locusts are carriers of pathogenic yeasts that can cause severe infections in humans – especially in people with compromised immune systems or who are seriously ill.

The study, ‘South African brown locusts, Locustana pardalina, hosts fluconazole resistant, Candidozyma (Candida) auris (Clade III)’, highlights for the first time the presence of the pathogenic (disease-producing) fungal yeast C. auris in the digestive tract of the locusts, and shows their potential in disseminating this emerging pathogen. The research started in April 2022, when 20 gregarious (swarming) adult locusts were collected during a large locust outbreak which occurred from September 2021 to May 2022 in the semi-arid Eastern Karoo region in the Eastern Cape. The study is still under peer review.

According to Prof Carlien Pohl-Albertyn, National Research Foundation (NRF) SARChI Research Chair in Pathogenic Yeasts, three C. auris strains were isolated from three different adult locusts, two of which also harboured strains of another potentially pathogenic yeast, Candida orthopsilosis. “The fact that we were able to isolate C. auris from 15% of the sampled locusts, using non-selective media and a non-restrictive temperature of 30°C, may indicate that C. auris is abundant in the locusts and that specific selective isolation is not mandatory,” Prof Pohl-Albertyn said.

“Interestingly, C. auris was isolated from the fore- and hindgut of the locusts. Isolation from the foregut, which is dedicated to food intake and storage, filtering and partial digestion, indicates that C. auris was probably obtained by the locusts via feeding activities. Isolation from the hindgut confirms that C. auris can survive the digestive processes in the midgut and is likely to be released back into the environment via faeces.”

Healthy humans are not at great risk

One of the C. auris strains was studied in more detail. This strain was not resistant to disinfectants but showed decreased susceptibility to the common antifungal drug fluconazole. This is a characteristic of this yeast species and thus not surprising. Most of the emerging pathogenic yeasts show this intrinsic resistance. This highlights the urgent need to discover and develop new antifungal drugs.

Prof Pohl-Albertyn, also a Professor of Microbiology in the UFS Department of Microbiology and Biochemistry, says, “Healthy humans are not at great risk for infection by this yeast and there is currently no proof that ingestion may be harmful to them. This is unfortunately not the case for people with compromised immune systems or who are seriously ill. However, few susceptible people come into direct contact with the locusts in South Africa.”

She added that there are treatment options available, using other antifungal drugs, but C. auris can become resistant to all the currently available antifungal drugs.

Importance of the study

“The fact that locusts are a food source for other animals, such as birds, could lead to eventual distribution of the yeast to people. In other countries, wild locusts are a food source for humans and there more direct transmission may be possible,” Prof Pohl-Albertyn said.

She explained that this study tries to answer questions regarding the natural hosts of this emerging pathogen and how it may facilitate the spread of the pathogen to the rest of the environment. The study is one part of the puzzle regarding how new pathogens may emerge from the environment and spread to people.

“One of the questions in the field of pathogenic yeasts is how C. auris was able to emerge as a pathogen in several different countries in a relatively short period. It is well known as a hospital-acquired pathogen, but it is not known where in the environment it occurs naturally, and which environmental factors may have shaped its evolution and ability to cause human infections. This has implications for the prevention of the spread of this specific yeast species, as well as our preparedness for new pathogenic yeasts that may be emerging from the environment.”

News Archive

First Black Rag Queen wants to give voice to voiceless
2017-02-22

Description: Coronation ball 2017 Tags: Coronation ball 2017

The winners of the 2017 Amanzi Coronation
ball are, from the left: Devina Harry,
Second Princess; Kgomotso Sebusi,
First Princess; Prudence Mahlaba, Rag Queen;
Suhail Peerbhai, Mr Rag; Jordan Nadasen,
First Runner-up; and Mohlale Matlala,
Second Runner-up.
Photo: Gerhardus Bosch


“It is true what they say about your purpose driving you towards your goal. The ride to eventually becoming the first black RAG Queen was motivated by a pure desire in my heart to help other people.”

This is the moving words of Prudence Mahlaba, who was crowned Rag Queen at the Amanzi Coronation Ball on Friday 17 February 2017. Suhail Peerbhai, a second-year BCom Economics student, was crowned Mr Rag 2017.

Giving a voice to the voiceless

Mahlaba says she wants to make a positive impact, “not only on the less fortunate, but also on the voiceless.” The fourth-year LLB student strives to adhere to the vision of the acronym RAG (Receive and Give). RAG is mainly about a good cause in order to make a difference.
“It is beauty with a purpose, practising what you preach, and doing unto others what you want them to do unto you,” Mahlaba said.

It was a night of glitz and glamour as the finalists made a last bid for the sought-after titles at the prestigious event held at the Student Church on the Bloemfontein Campus of the University of the Free State.

Role provide foundation for change
“Becoming Mr Rag is an exceptional feeling; however, this role entails much more responsibility,” Peerbhai said. “At a time like this, it has given me a solid foundation to make a difference in communities that are less fortunate.”

His advice to future participants in the contest is, “to go for it, since it entails the most life-changing challenges students in our era can face. No classroom teachings can provide you with the same values and experiences.”

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