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06 February 2025 | Story André Damons | Photo Supplied
Dr Jared McDonald
Prof Jared McDonald, Assistant Dean: Faculty of The Humanities at the University of the Free State, obtained his first National Research Foundation rating in the C2 category.

Obtaining his first National Research Foundation (NRF) rating has been the goal of Prof Jared McDonald, Assistant Dean: Faculty of The Humanities at the University of the Free State (UFS), since 2020 when he was selected for the UFS Transforming the Professoriate Mentoring Programme.

Prof McDonald obtained a C2 rating recently and credits the programme, under the leadership of Dr Henriëtte van den Berg, who provided invaluable support and mentorship, for this achievement. This rating recognises Prof McDonald as an established researcher and he may enjoy some international recognition for the quality and impact of his recent research outputs. 

“I am delighted to have received a C2 rating. I was hoping to obtain a C2, so when I received confirmation, it felt really good. Since being recruited to the Transforming the Professoriate Programme I have been focused on producing a series of quality journal articles, and importantly, my first monograph. At times it was a struggle to balance the demands of being Assistant Dean in the Faculty of Humanities along with my teaching responsibilities,” says Prof McDonald.

He says obtaining the rating would not have been possible without the interventions of the programme, which assisted him in securing funding for a sabbatical. The encouragement of colleagues and family was equally valuable in helping him to keep his eye on the goal.


Research 

As a nineteenth-century historian, Prof McDonald’s, who is an Associate Professor in the Department of History, research includes topics ranging from the London Missionary Society’s missions to the San as well as the role of controversial missionaries in influencing public discourse on the right to legal equality and social inclusion for indigenous subjects of the British Crown. Another topic is the ways in which evangelical-humanitarian discourse inadvertently provided the justification for the transfer of San children to Cape colonial society. 

“In my publications, the key actors, including Khoesan, are revealed to have been exercising agency in response to a social and political context that was not of their own choosing, but to which they had to respond. The contradictions of the period, coupled with the prospects for blurring the social boundaries of an otherwise strict hierarchical society, provided the means for social manoeuvre and options for resistance from within the confines of the colonial state. I am continuing to explore these ideas in a series of upcoming journal articles and book chapters,” he says. 

The pressure, says Prof McDonald, is already on to retain his rating, and hopefully improve it, when it comes up for review in five years’ time. He is currently working on his second monograph, which is a historical biography of a controversial, but fascinating, missionary who played a notable role in South African history in the early nineteenth century. “The worth of any historical biography lies in the biographer’s ability to shed light on the circumstances, contingencies, and contradictions that shaped the contours of the protagonist’s life, thus illuminating the historical context,” concludes Prof McDonald. 

He seeks to relate his research to his approach to teaching by exploring innovative ways of making the past relevant to students today. This is motivated by the conviction that the elucidation of possibilities of agency in the past raises the prospect for students to engage with the meanings and possibilities of agency in the present.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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