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25 February 2025 | Story Anthony Mthembu | Photo Kaleidoscope Studios
G20 - 2025
G20 delegates from member countries and other invited guests in attendance at the G20 Research and Innovation Working Group (RIWG) and G20 Initiative on Bioeconomy (GIB) meetings and other side events.

Against the backdrop of the upcoming G20 Summit to be hosted by South Africa in November 2025, the University of the Free State (UFS) – in partnership with the Department of Science, Technology and Innovation (DSTI) – held the G20 Research and Innovation Working Group (RIWG) and G20 Initiative on Bioeconomy (GIB) meetings on 23 and 24 February 2025.

In her opening address to G20 delegates from member countries, national and international knowledge partners, members of the Free State provincial government, and representatives of the DSTI, Prof Hester Klopper, Vice-Chancellor and Principal of the UFS, indicated, “It is an honour for the UFS to be among the few South African universities to host this essential Research and Innovation Working Group.” In addition, she highlighted that the deliberations and discussions set to take place during this important workshop can set in motion chains of events ultimately contributing to improved lives for everyone. These sentiments were also echoed by Prof Blade Nzimande, Minister of Science, Technology and Innovation, who underscored the importance and historic nature of the upcoming G20 Summit.

In his virtual address, Minister Nzimande explained that South Africa’s chosen theme for the G20 Summit – Solidarity, Equality and Sustainability – was inspired by the general complexity of our time, “in particular the transnational nature of these complexities, such as conflict, the displacement of people, poverty”, among other things. As such, he expressed that in this case, cooperation among nations is becoming increasingly essential.

As they concluded their addresses, Prof Nzimande and Prof Klopper, wished the delegates well in their deliberations. ‘’May your discussions be successful, and your goals be achieved. And may your time with us lead to a renewed experience of the value of innovation through connection, ‘’expressed Prof Klopper.

 

Contributing events

As part of the programme at these proceedings, several side events took place. These included panel discussions with indigenous knowledge holders such as Telle Hoeses, Chief Language Practitioner for Khoi and San Languages, along with experts of indigenous medicine. The conversation focused on indigenous knowledge systems (IKS) and some of the key concerns and progress that these knowledge holders have made in the space. In addition, these knowledge holders, many of whom are business owners who sell products made from indigenous medicines, also had the opportunity to exhibit their products. According to Dan du Toit, Deputy Director-General: International Cooperation and Resources at the DSTI, these panel discussions with young people, bioeconomy researchers, and indigenous knowledge holders were an opportunity to gain access to a diversity of voices, which would not normally find expression in formal meetings. “It is also an opportunity for our international guests to get insight into who we are as a country and what some of our concerns might be,” said Du Toit.

One of the highly anticipated side events on the programme was the joint G20 RIWG and GIB event titled ‘UNESCO Women and Girls in Science’, which took place on 25 February 2025. The event took the form of a round-table discussion, in an attempt to answer the question: Based on your experiences in various roles within higher education in South Africa, Africa, and globally, what are some key insights regarding the role of universities in closing the gender gap in STEM, specifically concerning professional development and creating supportive research environments where everyone, especially women, can thrive?

Prof Anthea Rhoda; Deputy Vice-Chancellor: Academic at the UFS, was one of the contributors in this session. In response to the question, Prof Rhoda highlighted, “Universities should also be spaces characterised by intellectual freedom and freedom of expression, where archaic ideas about male superiority and patriarchy can be openly confronted and contested, without fear of victimisation. She expressed that an active way in which the UFS has committed itself to a culture of diversity and inclusion is through Vision130.

As she was wrapping up her address, Prof Rhoda also highlighted, “To address areas of underrepresentation of women in senior academic and leadership positions within the university, a Working Group on Gender Parity in Academic Leadership was established, with the critical mandate to drive attitudinal shifts, advocate for changes where necessary, and highlight barriers to women’s advancement.”

 

The programme comes to an end

The last day of the programme was reserved for comments, reflections, and discussions on deliverables. As such, there were positive responses to the way the deliberations took place. In fact, Hoese, speaking in her capacity as an indigenous knowledge holder, said, “This was a good platform for us to make progress towards language recognition and officialisation.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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