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23 February 2025 | Story André Damons | Photo Supplied
UFS Main Building
The University of the Free State in partnership with the Department of Science, Technology and Innovation (DSTI), will form the backdrop for the G20 Research and Innovation Working Group (RIWG) and G20 Initiative on Biochemistry (GIB) meetings in February.

The University of the Free State (UFS) will form the backdrop for the G20 Research and Innovation Working Group (RIWG) and G20 Initiative on Bioeconomy (GIB) meetings on 23 and 24 February 2024.

UFS has, over the years, distinguished itself as a leader in the research and development, particularly in the biodiversity space through its African Medicines, Innovations and Technologies Development (AMITD) platform, which was established in collaboration with the Department of Science, Technology and Innovation (DSTI) and its entity, the Technology Innovation Agency.  It was therefore an obvious choice for the institution to again partner with the DSTI to host the G20 meetings.

The G20 is an international forum comprising many of the world's largest developing and developed economies, established to tackle pressing global economic and financial issues.

South Africa holds the G20 Presidency this year – only five years before the UN's 2030 Agenda for Sustainable Development deadline.  This is the first time the G20 is being hosted on African soil.

South Africa's presidency takes place when the world is facing a series of overlapping and mutually reinforcing crises, including climate change, underdevelopment, inequality, poverty, hunger, unemployment, technological changes, and geopolitical instability.

The G20 RIWG provides a platform for addressing global challenges through research, technology and innovation.  The DSTI will lead the RIWG under the leadership of Minister Blade Nzimande and explore this year's theme, "Equity in science and innovation-based approaches to sustainable development".

Prof Nzimande, along with Prof Hester Klopper, Vice-Chancellor and Principal of UFS, will both deliver opening remarks at the meeting.

The session on 23 February will be the first to include G20 officials engaging with indigenous knowledge holders, students and researchers in the bioeconomy.

Prof Motlalepula Matsabisa, Director of the Department of Pharmacology and AMITD at UFS, says the university was an excellent choice to host the sessions because of its trusted relationships with indigenous communities and focus on inclusive research and development.

The G20 dialogues aim to be inclusive and provide a space for members of the public to voice their aspirations and to capture their needs around the indigenous knowledge and biodiversity in which they play an integral role.

"I am honoured to be part of this global event.  I am so happy that AMITD is now globally recognised.  We will exhibit our research conducted with communities on the internationalisation of South African science research in traditional medicines and biodiversity, and its formal commercialisation," said Prof Matsabisa.

"We are the leader in traditional medicines research and development.

"South Africa always leads in global debates and sets the stage for African views to be heard.  We will contribute to policies on global biodiversity and bioeconomy and commercialisation of our natural resources through equity, sustainability and solidarity.

Prof Matsabisa believes this event will also highlight the goals of the DSTI's 2019 White Paper on Science, Technology and Innovation and the implementation of its 2022-2032 Decadal Plan.

He hopes to see tangible and meaningful outcomes from the G20 discussions that will be implemented by the USA when it takes over the G20 Presidency for 2026.

News Archive

Dr Charlotte Boucher and Lindi Heyns examine possible anti-microbial activity in the skin of Western olive toad species
2014-12-22

 

Researchers Lindi Heyns and Dr Charlotte Boucher are working together on an interdisciplinary project between the Departments of Zoology and Entomology and Veterinary Biotechnology at the University of the Free State (UFS). The focus of their research is on the preliminary biochemical description of skin secretions in some South African toads.

The project forms part of an Honours study executed by Dwayne Pike under Heyns’ supervision. He is co-supervised by Dr Boucher who is assisting with the biochemical and microbiological assays.

Dr Boucher said, “Amphibians are characterised by the presence of cutaneous glands spread over the skin. There are two types of glands, namely mucous and granular (poison), located on the inner surface of the epidermis. Mucous glands are widely dispersed over the skin, while granular glands can be grouped and enlarged in specific regions. Mucous glands are generally associated with maintenance of humidity and cutaneous respiration, whereas granular glands function in chemical defence against predators and/or microbial infection. Studies indicate that the compounds produced by the granular glands belong to numerous chemical classes with diverse pharmacological activities.”

The products secreted by granular glands are rich in low molecular weight constituents of varied molecular types, including proteins, peptides and toxins. These secretions make the toad foul-tasting to predators and even toxic to other frog species. In addition, amphibians offer an attractive source of novel antimicrobials. Studies indicate that as a response to inhabiting microorganism-rich environments they synthesise and secrete a diverse array of antimicrobial peptides (AMPs) as an innate form of defence. Extensive research by various other research groups has been carried out on antimicrobial peptides of the genus Rana; however, hardly any studies have investigated the antimicrobial activity of African frog species.

The focus of this preliminary project is to determine the protein composition of the glandular secretions of the Western olive toad (Amietophrynus poweri), using biochemical tests, such as SDS-PAGE also known as protein gel electrophoresis combined with mass-spectrometry used to identify unknown peptides and proteins. This will give us an overview of the composition of the glandular secretions. Furthermore, we are also looking at microbiological tests, which include assays that test for possible anti-microbial activity against various bacterial and fungal species.

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