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30 January 2025 | Story Jacky Tshokwe | Photo Supplied
Samantha Durrant
Samantha Durrant, the first violinist and Artistic Leader of the Odeion String Quartet, appointed since May 2024.

In the world of music, certain instruments resonate not just with sound, but with profound emotion and history. For Samantha Durrant, her journey with the violin began at the tender age of seven, inspired by the heartfelt story of Music of the Heart. This film, coupled with her exposure to the harmonious symphonies of the KwaZulu-Natal Philharmonic Orchestra, planted seeds that grew into a lifelong devotion to the violin and classical music.

Now, as part of the Odeion String Quartet – the only quartet in residence at a South African university – Durrant stands at the forefront of a mission that transcends performance. She sees her role not only as a performer, but as a steward of South Africa’s string-playing legacy. Her vision is bold yet grounded: to make the Odeion String Quartet the centrepiece of string training and performance in the country.

Reflecting on her journey, Durrant emphasises the critical role of mentorship, exposure, and perseverance. "There wasn’t one pivotal moment in my career," she shares. "It was the culmination of experiences with colleagues, mentors, and friends, all encouraging me to push my boundaries."

The Odeion String Quartet is bridging South African talent with global excellence, performing works by masters such as Haydn and Beethoven while celebrating contemporary compositions, including those from South Africa's rich tapestry of composers. For Durrant, the opportunity to collaborate with living composers is an unparalleled gift, offering insights into their inspirations and musical intentions.

Education and community are at the heart of the quartet's mission. Through school concerts, youth orchestra engagements, and performances at prestigious events such as the Vice-Chancellor’s Concert and the Rector’s Farewell, the quartet inspires audiences of all ages. "Youth orchestras represent unity," Durrant notes. "They bring people together, showcasing our shared humanity."

To those stepping into the challenging world of music, Durrant offers sage advice: "Be patient with yourself. Understand that this field is not easy, but the journey of self-discovery it offers is unparalleled."

With a packed performance calendar and ambitious goals for the quartet’s future, Durrant remains hopeful about music's place in society. "Music has the power to heal, inspire, and unite," she says. "In these challenging times, it is balm for the soul – an essential part of our humanity."

As the Odeion String Quartet continues its journey, its melodies remind us of the transformative power of music, resonating with hope and possibility across generations.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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