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13 January 2025 | Story Dr Nitha Ramnath | Photo Sonia Small
Prof Brownhilder Neneh
Prof Brownhilder Neneh stands out as an inspiring force for students and aspiring entrepreneurs.

In the dynamic intersection of tradition and innovation within academia, Prof Brownhilder Neneh, Vice-Dean: Research, Engagement and Internationalisation in the Faculty of Economic and Management Sciences at the University of the Free State (UFS), stands out as an inspiring force for students and aspiring entrepreneurs. Her remarkable career trajectory – ascending rapidly through the ranks from senior lecturer to head of department, and ultimately to full professor – has been marked not only by professional accolades, but by a deep, personal impact on the lives of her students and the broader entrepreneurial community. 

Personal moments of student connection  

Reflecting on her career, Prof Neneh’s achievements are impressive. “The best moment of my career is twofold,” she explains. “Professionally, I am incredibly grateful for the success I’ve achieved in less than a decade. Being promoted to professor, launching my book this year, and being consistently recognised as one of the top-cited researchers in the world over the past two years – it’s all been surreal.” 

However, it is the personal connections with her students that leave the most lasting impression. One student shared a heartfelt message, recalling how Prof Neneh’s encouragement helped her persevere through academic challenges. “You have everything it takes to succeed,” Prof Neneh had told her, transforming her outlook on her studies. Another student credited Prof Neneh’s words of encouragement with sparking a journey of self-acceptance, reminding her that “the best is yet to come.” These experiences highlight the profound influence of mentorship and the power of positive reinforcement. 

Building entrepreneurial competencies 

Prof Neneh’s research centres on fostering entrepreneurial skills, with a particular focus on youth and women. “I wish people knew that my work is about making a real, tangible difference,” she notes. Her research addresses the unique challenges faced by women entrepreneurs, including the complexities of work-life balance and societal pressures. By providing evidence-based strategies drawn from her extensive experience, Prof Neneh seeks to empower those navigating the intersection of family and business obligations. 

She also emphasises the obstacles facing young entrepreneurs, such as limited access to resources and a fear of failure. “These challenges can deter aspiring entrepreneurs from taking risks and pursuing their dreams,” Prof Nene says. Her approach to teaching entrepreneurship is rooted in practical, evidence based advice, encouraging aspiring entrepreneurs to pursue their passions, employ ‘effectual reasoning’ in building their ventures with available resources – and commit to lifelong learning. “Training doesn’t stop at obtaining a degree. It’s about continually seeking knowledge and adapting to the market,” she asserts. 

Prof Neneh also advocates collaboration through a concept she calls ‘coopetition’ – where competition fosters cooperation, particularly in overcoming resource constraints. This mindset has been especially valuable during times of crisis, such as the recent pandemic, when industries banded together for collective growth. 

For budding entrepreneurs, Prof Neneh offers a wealth of practical advice. She stresses the importance of validating the market before launching a business, while cautioning against entering fields devoid of passion or thorough preparation. Her guiding principle? “Invest wisely and understand the needs of your target market.” 

Creating ripples of positive impact 

Looking ahead, Prof Neneh embodies resilience. “I wouldn’t change anything in my life. Every challenge has been a lesson,” she reflects. Her experiences have not only shaped her career, but also strengthened her sense of purpose. “Stay true to your values and purpose,” is the advice she follows, ensuring her life’s work continues to create ripples of positive impact. 

Prof Neneh is not only an academic; she is a champion for change, dedicated to uplifting others through her research, mentorship, and community initiatives such as ‘She Believe’, a peer support group focused on empowering women. As she continues to inspire future generations, her story serves as a powerful reminder that the entrepreneurial journey is not merely about financial success – it is about transformative impact and demonstrating resilience. 

The belief that “the best is yet to come” resonates not only in Prof Neneh’s life, but also with everyone who has the privilege of learning from her.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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