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13 January 2025 | Story Dr Nitha Ramnath | Photo Sonia Small
Prof Brownhilder Neneh
Prof Brownhilder Neneh stands out as an inspiring force for students and aspiring entrepreneurs.

In the dynamic intersection of tradition and innovation within academia, Prof Brownhilder Neneh, Vice-Dean: Research, Engagement and Internationalisation in the Faculty of Economic and Management Sciences at the University of the Free State (UFS), stands out as an inspiring force for students and aspiring entrepreneurs. Her remarkable career trajectory – ascending rapidly through the ranks from senior lecturer to head of department, and ultimately to full professor – has been marked not only by professional accolades, but by a deep, personal impact on the lives of her students and the broader entrepreneurial community. 

Personal moments of student connection  

Reflecting on her career, Prof Neneh’s achievements are impressive. “The best moment of my career is twofold,” she explains. “Professionally, I am incredibly grateful for the success I’ve achieved in less than a decade. Being promoted to professor, launching my book this year, and being consistently recognised as one of the top-cited researchers in the world over the past two years – it’s all been surreal.” 

However, it is the personal connections with her students that leave the most lasting impression. One student shared a heartfelt message, recalling how Prof Neneh’s encouragement helped her persevere through academic challenges. “You have everything it takes to succeed,” Prof Neneh had told her, transforming her outlook on her studies. Another student credited Prof Neneh’s words of encouragement with sparking a journey of self-acceptance, reminding her that “the best is yet to come.” These experiences highlight the profound influence of mentorship and the power of positive reinforcement. 

Building entrepreneurial competencies 

Prof Neneh’s research centres on fostering entrepreneurial skills, with a particular focus on youth and women. “I wish people knew that my work is about making a real, tangible difference,” she notes. Her research addresses the unique challenges faced by women entrepreneurs, including the complexities of work-life balance and societal pressures. By providing evidence-based strategies drawn from her extensive experience, Prof Neneh seeks to empower those navigating the intersection of family and business obligations. 

She also emphasises the obstacles facing young entrepreneurs, such as limited access to resources and a fear of failure. “These challenges can deter aspiring entrepreneurs from taking risks and pursuing their dreams,” Prof Nene says. Her approach to teaching entrepreneurship is rooted in practical, evidence based advice, encouraging aspiring entrepreneurs to pursue their passions, employ ‘effectual reasoning’ in building their ventures with available resources – and commit to lifelong learning. “Training doesn’t stop at obtaining a degree. It’s about continually seeking knowledge and adapting to the market,” she asserts. 

Prof Neneh also advocates collaboration through a concept she calls ‘coopetition’ – where competition fosters cooperation, particularly in overcoming resource constraints. This mindset has been especially valuable during times of crisis, such as the recent pandemic, when industries banded together for collective growth. 

For budding entrepreneurs, Prof Neneh offers a wealth of practical advice. She stresses the importance of validating the market before launching a business, while cautioning against entering fields devoid of passion or thorough preparation. Her guiding principle? “Invest wisely and understand the needs of your target market.” 

Creating ripples of positive impact 

Looking ahead, Prof Neneh embodies resilience. “I wouldn’t change anything in my life. Every challenge has been a lesson,” she reflects. Her experiences have not only shaped her career, but also strengthened her sense of purpose. “Stay true to your values and purpose,” is the advice she follows, ensuring her life’s work continues to create ripples of positive impact. 

Prof Neneh is not only an academic; she is a champion for change, dedicated to uplifting others through her research, mentorship, and community initiatives such as ‘She Believe’, a peer support group focused on empowering women. As she continues to inspire future generations, her story serves as a powerful reminder that the entrepreneurial journey is not merely about financial success – it is about transformative impact and demonstrating resilience. 

The belief that “the best is yet to come” resonates not only in Prof Neneh’s life, but also with everyone who has the privilege of learning from her.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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