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02 January 2025 | Story Edzani Nephalela | Photo Lethabo Machabaphala
Prof Allan Boesak
From the left are, Prof John Klaasen, Dean of the Faculty of Theology and Religion; Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS; Prof Anthea Rhoda, acting Vice-Chancellor and Principal of the UFS; Prof Allan Boesak; Prof Nico Koopman, Deputy Vice-Chancellor: Social Impact, Transformation and Personnel at Stellenbosch University; and Dr Eugene Fortein, Senior Lecturer: Historical and Constructive Theology at Prof Boesak’s book launch.

In a world increasingly defined by the stark contrasts of power and vulnerability, the concept of democracy often reveals itself as a double-edged sword. For the children of struggle – those who have grown up amid the chaos of inequality and conflict – democracy can feel like a distant promise, an ideal often outmanned by the realities they face. The deception of hope lingers in the air as aspirations clash with systemic barriers, leaving many to navigate a landscape where a harsh daily existence obscures the principles of freedom and justice. This exploration seeks to uncover the intricate dynamics between hope and disillusionment, shedding light on the lived experiences of those who yearn for a brighter future yet grapple with the weight of unfulfilled promises.

This was the essence of the public lecture titled Outmanned by Democracy: Children of Struggle, Deception, and Hope, presented by Prof Allan Boesak, a theologian and political activist, on the Bloemfontein Campus.

Prof Boesak confronted the continuous socio-economic challenges faced by South Africa and other nations, including racism, narrow ethnic nationalism, and the revival of tribalism. He emphasised the role of churches in tackling these issues. “The responsibility of churches is to articulate what politicians are often afraid to say,” he stated. “Put your ideologies into practice and leverage your power as ministers of the Word to shape the future and reclaim the dignity of your people. This is where unity transcends colour and stature. Consider the various roles that churches could play in reconciling communities, as seen in the Gaza crisis.”

During his visit to the UFS Faculty of Theology and Religion, Prof Boesak also launched a four-volume set titled The Fire, The River and the Scorched Earth: Fifty Years of Black Theology Through the Lens of Allan Boesak. The first three volumes include his lectures and responses from various theologians, while the fourth contains his sermons. This body of work aims to document, critique, and celebrate the contributions of black theology, highlighting its role in the struggle for justice and liberation and underscoring Prof Boesak’s unwavering commitment to freedom, liberation, and democracy.

In a time when hope and disillusionment coexist, Prof Boesak’s insights remind us of the transformative power of faith and activism in the continuing fight for a more equitable world

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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