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12 June 2025 | Story André Damons | Photo Department of Science, Technology, and Innovation
Prof Motlalepula Matsabisa
Prof Motlalepula Matsabisa, a specialist in indigenous knowledge systems from the Department of Pharmacology at the University of the Free State (UFS), and Jansie Niehaus, NSTF Executive Director and Company Director, at the Second Ministerial Belt and Road Science and Technology conference (BRT) in China.

Prof Motlalepula Matsabisa, a specialist in indigenous knowledge systems from the Department of Pharmacology at the University of the Free State (UFS), is part of a delegation with Prof Blade Nzimande, minister of Science, Technology, and Innovation (DSTI), to the Second Ministerial Belt and Road Science and Technology conference (BRT) in China. 

The conference is being held in Chengdu from 11-12 June 2025 and will gather representatives from state-level agencies, scientific academies, and innovation enterprises from countries involved in the Belt and Road Initiative, including members of the Association of Southeast Asian Nations (ASEAN) and the Shanghai Cooperation Organisation. The theme of the conference is “Together for Innovation, Development for All – Jointly Building a Scientific and Technological Innovation Community for the Belt and Road”. 

Prof Matsabisa, Research Director of the African Medicines Innovations and Technologies Development at the UFS, is the only person from a South African university to be invited by Prof Nzimande as part of this ministerial trip. Other members of the delegation include members from the minister’s department, CEOs and board members of agencies that report to the DSTI – namely Technology Innovation Agency (TIA), the National Science and Technology Forum (NSTF), Council for Scientific and Industrial Research (CSIR), National Advisory Council on Innovation, Human Sciences Research Council of South Africa, South African Council for Natural Scientific Professions, National Science and Technology Forum (NSTF), National Advisory Council on Innovation (NACI), South African National Space Agency and the National Research Foundation (NRF). 

As a guest professor at the Beijing University of Chinese Medicine (BUCM) in Beijing, Prof Matsabisa accompanied the delegation on a visit to the university where he has a longstanding relationship. The UFS has the only active university collaboration within the China-South African Science and Technology bilateral agreement.

 

Supporting around aspects of traditional medicine 

According to a statement on the South African government website, Prof Nzimande expressed the department’s intention to strengthen collaboration with the Beijing University and the Aerospace Research Institute of the Chinese Academy of Sciences, in the areas of indigenous knowledge systems and space science, respectively. The minister visited both the BUCM and the Aerospace Information Research Institute of the Chinese Academy of Sciences this week. 

“It is an honour to be part of the minister’s delegation given that I am the only person from a university amongst the agencies. The UFS is indeed very honoured to have been the only one identified to be in this ministerial trip. I am honoured to make connections with the decision-makers such as the chairperson of the board of TIA and the CEO of NSTF and all the other CEOs. It’s indeed an honour to share our work with people from NACI and the minister’s office at DSTI. This really could not have been a better opportune moment for me,” says Prof Matsabisa. 

According to him, he is there to support Prof Nzimande around aspects of traditional medicine as well as with his meeting with the Chinese Minister of Science and Technology during the signing of a letter of intent on traditional medicines including in the BRT conference where the minister will give a talk that will cover traditional medicines. Prof Matsabisa says he is looking forward to strengthening the relationships between the UFS and BUCM and China as well as sharing with the minister the joint projects and joint students from both institutions, hoping for continued support and funding.

“This trip has opened new opportunities. TIA has invited me and the UFS to be part of their new project on neurodegenerative diseases with Cuba. It was wonderful to hear that both the CEO and the chairperson of the board had already been briefed about me to be part of the project.

“It is also great to be present at the signing of the letter of intent on traditional medicine as it is important to know where the policies are heading.”

News Archive

Research eradicates bacteria from avocado facility
2017-01-17

 Description: Listeria monocytogenes Tags: Listeria monocytogenes

Listeria monocytogenes as seen under an electron
microscope. The photo was taken with a transmission
electron microscope at the microscopy unit of the UFS.
Bacteriophages (lollipop-like structures) can be seen
next to the bacterial cells.
Photo: Supplied

“The aim of my project was to identify and characterise the contamination problem in an avocado-processing facility and then to find a solution,” said Dr Amy Strydom, postdoctoral fellow in the Department of Microbial Biochemical and Food Biotechnology at the University of the Free State (UFS).

Her PhD, “Control of Listeria monocytogenes in an Avocado-processing Facility”, aimed to identify and characterise the contamination problem in a facility where avocados were processed into guacamole. Dr Strydom completed her MSc in food science in 2009 at Stellenbosch University and this was the catalyst for her starting her PhD in microbiology in 2012 at the UFS. The research was conducted over a period of four years and she graduated in 2016. The research project was funded by the National Research Foundation.

The opportunity to work closely with the food industry further motivated Dr Strydom to conduct her research. The research has made a significant contribution to a food producer (avocado facility) that will sell products that are not contaminated with any pathogens. The public will then buy food that is safe for human consumption.


What is Listeria monocytogenes?

Listeria monocytogenes is a food-borne pathogenic bacterium. When a food product is contaminated with L. monocytogenes, it will not be altered in ways that are obvious to the consumer, such as taste and smell. When ingested, however, it can cause a wide range of illnesses in people with impaired immune systems. “Risk groups include newborn babies, the elderly, and people suffering from diseases that weaken their immune systems,” Dr Strydom said. The processing adjustments based on her findings resulted in decreased numbers of Listeria in the facility.

The bacteria can also survive and grow at refrigeration temperatures, making them dangerous food pathogens, organisms which can cause illnesses [in humans]. Dr Strydom worked closely with the facility and developed an in-house monitoring system by means of which the facility could test their products and the processing environment. She also evaluated bacteriophages as a biological control agent in the processing facility. Bacteriophages are viruses that can only infect specific strains of bacteria. Despite bacteriophage products specifically intended for the use of controlling L. monocytogenes being commercially available in the food industry, Dr Strydom found that only 26% of the L. monocytogenes population in the facility was destroyed by the ListexP100TM product. “I concluded that the genetic diversity of the bacteria in the facility was too high and that the bacteriophages could not be used as a control measure. However, there is much we do not understand about bacteriophages, and with a few adjustments, we might be able to use them in the food industry.”

Microbiological and molecular characterisation of L. monocytogenes

The bacteria were isolated and purified using basic microbiological culturing. Characterisation was done based on specific genes present in the bacterial genome. “I amplified these genes with polymerase chain reaction (PCR), using various primers targeting these specific genes,” Dr Strydom said. Some amplification results were analysed with a subsequent restriction digestion where the genes were cut in specific areas with enzymes to create fragments. The lengths of these fragments can be used to differentiate between strains. “I also compared the whole genomes of some of the bacterial strains.” The bacteriophages were then isolated from waste water samples at the facility using the isolated bacterial strains. “However, I was not able to isolate a bacteriophage that could infect the bacteria in the facility.

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