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16 May 2025 | Story André Damons | Photo Supplied
Dr Lisa Rothmann
Dr Lisa Rothmann, a plant disease epidemiologist from the University of the Free State (UFS), has been nominated in the TW Kambule-NSTF Award: Emerging Researcher category for this year’s NSTF-South32 Awards.

Dr Lisa Rothmann, a plant disease epidemiologist from the University of the Free State (UFS) who was nominated in the TW Kambule-NSTF Award: Emerging Researcher category for this year’s NSTF-South32 Awards, says that the nomination is a reminder that service through science matters.

“I am humbled by the nomination. For me, it reflects not just individual recognition, but also the shared effort of the team of postgraduate academics, research assistants, partners, and farmers with whom I've had the privilege to work with. It is affirming to see plant pathology and field-based research recognised in this way; it highlights the consistent (hard) work we do to make a meaningful contribution to agriculture and to serve the grain industry and farmers,” says Dr Rothmann. 

She was nominated by Grain South Africa (Grain SA), with whom she has been working closely since 2018 to contribute research that aligns with the organisation’s mission to strengthen the grain sector. They play a key role in supporting sustainable grain production and farmer development. 

Dr Rothmann, who is one of eight UFS researchers and a research team nominated for the NSTF-South32 Awards – also known as the ‘Science Oscars’ – is nominated for her contribution to interdisciplinary, team-based research to develop practical solutions for plant diseases in order to protect crops and empower communities. 

 

Motivation to keep growing

The Senior Lecturer in the Department of Plant Sciences within the Faculty of Natural and Agricultural Sciences (NAS) says that while she is proud of the work she has done, she sees this recognition as a team effort. Says Dr Rothmann: “It motivates me to keep growing as a researcher, rooted in impact and integrity. I’m not a prolific peer-reviewed publisher; my academic record includes 10 journal articles and one book chapter, but I have written around 50 popular articles – often as a solo author, in collaboration with postgraduates and peers.” 

“These pieces translate plant pathology topics such as the Sclerotinia life cycle, disease surveillance, and management into accessible information for producers and the public. To me, this nomination is a symbol that making a meaningful impact doesn't only come from journal impact factors. This nomination has reminded me that building a career in academia is a relay, not a race, and that lasting impact comes from investing in others.”

As a plant disease epidemiologist, she specialises in field pathology – an area of plant pathology that explores how disease epidemics in crops develop, spread, and can be effectively managed within agricultural systems. Their work centres on understanding and managing Sclerotinia diseases in oilseed and protein crops such as canola, soybean, and sunflower, as well as disease surveillance in key grain crops including dry bean, sorghum, and sunflower.

 

New research

After participating in the US-based National Sclerotinia Initiative in 2017, she was inspired to establish a South African Sclerotinia Research Network with the support of Grain SA, creating a platform for researcher collaboration, farmer engagement, and the development of on-farm management strategies. Over time, explains Dr Rothmann, their research has expanded to include cultivar screening, national disease surveys, fungicide registration trials, and the development of disease-assessment tools. More recently, they have embedded sociological surveys into sorghum disease work to better understand farmers’ knowledge and needs, ensuring that research remains practical and co-created with producers.

According to Dr Rothmann, they have been privileged to work in a space that supports producers and protects crops through applied plant disease management strategies. While high-value crops often attract attention due to export markets, the grain that feed the nation forms the backbone of food security. As part of their new research, Dr Rothman and the research team are currently contributing to the Sorghum Cluster Initiative's pre-breeding programme, where they have screened 160 accessions for diseases to support future cultivar development. 

They are also going to explore how both emerging and commercial farmers will adopt these new cultivars. She is actively seeking collaborators in sociology/psychology or similar fields to better understand farmers’ decision-making. They are developing a plant disease dashboard to map disease occurrences across South Africa – an effort aligned with the Plant Health (Phytosanitary) Act 35 of 2024 to help guide appropriate disease risk categorisation. In the long term, concludes Dr Rothmann, they hope to establish a diagnostic hub for central South Africa in partnership with Agricultural Research Council-Grain Crops to strengthen local disease identification and support producers in real time.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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