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28 October 2025 | Story Andile Mbowana | Photo Supplied
PhD candidates at the 2025 National 3MT Competition, hosted at the University of the Free State.

The University of the Free State Centre for Graduate Support (CGS) hosted the 2025 National Three-Minute Thesis (3MT) Competition on 24 October in the Albert Wessels Auditorium, bringing together some of South Africa’s brightest PhD minds under one roof. The annual event, which has become a highlight on the national academic calendar, challenges doctoral candidates from universities across the country to present their complex research in just three minutes, using language accessible to a non-specialist audience. 

This year’s competition drew impressive presentations from top scholars representing various disciplines – from health sciences and agriculture to humanities – all showcasing the depth and diversity of South Africa’s research landscape.

Delivering the keynote address, Prof Vasu Reddy, Deputy Vice-Chancellor: Research and Internationalisation at the UFS, reflected on The Essence of Postgraduate Studies and Success in South Africa. He emphasised that postgraduate research plays a critical role in shaping innovation and addressing the country’s most pressing challenges. “As postgraduates, you represent a powerful tool of transformation, equity, and innovation, and every thesis is a story of resilience and a long journey of research,” he said. Prof Reddy also talked about how “competitions like the 3MT not only celebrate research excellence but also teach scholars how to communicate their ideas to inspire real-world impact,” praising the competition for opening opportunities for postgraduate scholars. 

The University of the Free State was represented by two candidates, Rentia du Plessis from the Faculty of The Humanities, who presented her 3MT title, Exploring Instructional Communication Strategic for Holistic Student Development, and Naquita Fernandes from the Faculty of Economic and Management Sciences, with her 3MT title, Triggering Online Review Generation Behaviour

Other universities, such as the Nelson Mandela University, Unisa, the University of KwaZulu-Natal, the University of the Western Cape, the University of Johannesburg, and the University of Pretoria, were also present.

After a series of captivating presentations, Robinah Nakawunde from Stellenbosch University claimed the top prize. Representing the Faculty of Medicine and Health Sciences, her presentation titled, Cured but Not Healed: Uncovering the Lung’s Struggles after TB, captured the attention of both the judges and the audience. Her research sheds light on how pulmonary tuberculosis continues to affect lung function even after successful treatment, highlighting the need for improved post-TB health-care interventions.

The first runner-up position went to Aaron Harvey from the University of Pretoria’s Faculty of Natural and Agricultural Sciences, whose research explores how avocado plants fight root rot disease using RNA interference mechanisms. His presentation, titled How Avocado Cells Fight Against the Root Rot Disease Caused by Phytophthora cinnamomi, Using RNAi Gatekeepers, impressed the judges with its clarity and scientific depth.

Morgan Lee from the University of Cape Town’s Faculty of Humanities took home the second runner-up prize. Her presentation, Locked In: The Hidden Barriers to Sustainable Agriculture, tackled the challenges facing South Africa’s commercial grain sector in transitioning towards more sustainable practices, offering insights that bridge environmental and social considerations.

The 2025 3MT National Competition once again demonstrated the power of concise, impactful communication in research. As the curtain closed, it was evident that South Africa’s future of research and innovation remains in capable hands, ones that can not only investigate deeply, but also explain passionately

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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