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09 September 2025 | Story Martinette Brits | Photo Stephen Collett
Prof Botma Visser
Prof Botma Visser delivered his inaugural lecture at the University of the Free State, highlighting nearly two decades of research on wheat rust and global food security.

Safeguarding one of the world’s most vital staple foods was at the heart of the inaugural lecture delivered by Prof Botma Visser, Professor in the Department of Plant Sciences at the University of the Free State (UFS), on Wednesday 3 September 2025. Prof Visser shared insights from nearly two decades of research into wheat rust – a devastating crop disease that threatens both South Africa’s harvests and global food security.

“Wheat production in South Africa is threatened by three fungal pathogens that cause rust disease on the crop. Understanding the factors that contribute to virulence on locally grown cultivars is crucial to ensure continued wheat production,” said Prof Visser.

 

The fight against evolving wheat rusts

For the past 17 years, Prof Visser’s research has focused on the genetic structure of rust populations and the risks they pose to food security. His work has shown that these populations are dynamic and constantly changing due to genetic mutations within existing races, as well as the introduction of new races into South Africa.

“Computer modelling showed that rust can spread over vast distances by prevailing winds. During the 20th Century, at least four Southern African stem rust races managed to move across the Indian Ocean from Southern Africa to Australia. South Africa, in turn, received multiple new races from mid-Africa across Zambia and Zimbabwe, without any means of stopping these introductions,” he explained.

To respond to this challenge, his team recently implemented MARPLE (Mobile And Real-time Plant disEase) diagnostics using fourth-generation nanopore sequencing technology. This approach allows the rapid characterisation of fungal isolates, specifically targeting genes linked to fungicide resistance and virulence.

“This work,” Prof Visser noted, “is part of an effort to safeguard global wheat production.”

His research is a collaborative effort with Prof Willem Boshoff (Department of Plant Sciences, UFS) and Dr Tarekegn Terefe (Agricultural Research Council – Small Grain, Bethlehem). Together, their work has positioned the UFS as an internationally recognised centre of excellence in wheat rust research.

 

About Prof Botma Visser

Prof Botma Visser obtained his BSc in Botany and Microbiology (1988), BSc Honours in Microbiology (1989), and MSc in Botany (1993) at the University of the Free State, where he also completed his PhD in Botany in 2004.

His career spans more than 18 years of research into wheat rust pathogens, combining annual surveys, race pathotyping, molecular genetics, and cutting-edge sequencing technologies. His expertise has not only advanced understanding of rust population dynamics in South Africa but also contributed to global collaborative studies on crop disease.

News Archive

Nano research at the UFS opens door to smart drugs
2011-06-27

 

Prof. Lodewyk Kock, outstanding professor in our Department of Microbial, Biochemical and Food Biotechnology

Novel antifungal, anticancer and anti-malaria drugs that have been identified in the research of Prof. Lodewyk Kock, outstanding professor in the Department of Microbial, Biochemical and Food Biotechnology at our university, will be disclosed later this year at major international conferences in Asia, Europe and the USA. Prof. Kock will be the keynote speaker at these conferences. 

His presentations will be based on the department’s discovery of yeast assays linked to a new nanotechnology for medicine. The assays were recently discovered by his group and can be applied in the development of novel antifungal, anticancer and anti-malaria drugs.
 
Prof. Kock’s focused research at the university, which now also includes his novel nanotechnology for Biology, began in 1982 in collaboration with Prof. Pieter van Wyk (Centre for Microscopy). He recently collaborated with Prof. Hendrik Swart (Department of Physics).
 
Prof. Kock says the development of novel anti-malaria drugs in particular is getting attention across the world due to the high rates of morbidity and mortality caused by the disease worldwide. Approximately 225 million people are infected annually and about a million (many in Africa) die each year. “Many potential smart drugs have been identified with this research and should now be tested further,” says Kock.
  
These new drugs will be disclosed during Prof. Kock’s keynote addresses at the International Conference and Exhibition on Pharmaceutical Regulatory Affairs in Baltimore, USA, from 6 to 7 September 2011, the Medichem 2011 in Beijing, China from 9 to 11 August 2011 and the XVI Congress of European Mycologists in Greece, from 19 to 23 September 2011.

 

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